ID A0A0V0XV94_TRIPS Unreviewed; 1820 AA.
AC A0A0V0XV94;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Fatty acid synthase {ECO:0000256|ARBA:ARBA00018769};
DE EC=2.3.1.85 {ECO:0000256|ARBA:ARBA00012873};
DE EC=3.1.2.14 {ECO:0000256|ARBA:ARBA00012480};
DE Flags: Fragment;
GN Name=Fasn {ECO:0000313|EMBL:KRX91762.1};
GN ORFNames=T4E_10852 {ECO:0000313|EMBL:KRX91762.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX91762.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX91762.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX91762.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX91762.1}.
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DR EMBL; JYDU01000128; KRX91762.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0019171; F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0004316; F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004313; F:[acyl-carrier-protein] S-acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016297; F:acyl-[acyl-carrier-protein] hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0047117; F:enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0032787; P:monocarboxylic acid metabolic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08954; KR_1_FAS_SDR_x; 1.
DR Gene3D; 1.10.287.1960; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR049391; FAS_pseudo-KR.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001031; Thioesterase.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF7; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF21149; FAS_pseudo-KR; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815}.
FT DOMAIN 1431..1508
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX91762.1"
SQ SEQUENCE 1820 AA; 204640 MW; 15D9C1D2D864DE3E CRC64;
LRSSRWISSS VPQSNWDTDL GKFCSAEYHV NNTMSTVLFN EALQHVPKNA IVIEIAPHCL
LQAVLRRAVD SSCVLSGLMK AKHENNVEYF CTALGKLFEA GLVLNPHCLY NQESYPVPLS
TPMISPLIEW DHSAEWPVVS TQDLLAGGAG GIASSCSIVV DPFNPETKDQ YLLDHVIDGR
VLFPFTGHLI YAWRALCKIR GLDMNKTPIV IEDFHVYRAT ILNRAVKFNI TVSHANGSFE
ILEGDSLAAS GRITIVDYER PLFYQKIDEV QPNTECERIK LSSADVYKEL LLRGYEYGPS
FKCIYESCNS GDRTLVLWSD NWVTFLDSVL QTALLFEKAD TLKLPTRLRY LRIDPQKHLK
SVIHNENLKL VISRSDSATK GFSAGGVEVC ELIAQTVPRR LNHGEKVHIE RVHFIPNYSQ
NCFTNFPDIR EKLLKYKPVC LALFQQFLQA QAKTMDQLFD VDNFERFRIK LTETPDTVAA
EILDELDDDS FPVGRMLREL TESLSDFQDK DELMEGIATY RENLPHDLFW NGSGHELCLK
SFLDAALENN ACHSDKICMF EPSDIVFPTL CYDLQRSHPL VQVNWTFVGQ NIDSSYANLP
AEILELDTNA EEVTVPVAHQ NKDLVILNRV LWSKSDINGY LEKVKLFMRD DGFCLVNEIT
DHFDLAVTLL TLLNGSVPVG KDNSRIHGLF LDFNSWVETF TKADFHIVCS HSDAMMGSLF
LLRKKVSIPR EPIIINIDDV KEFSWVPELK EALEKHAAED QTTIWLTSKL HDNGTVGLAL
CLREEYLKNK IRSLADVSLK TKDSETTNSW DFNSEEIKEI LYKDMHSNLY KNGTWGTFRY
YRIRDEEAFH CEPTEHAFIT TLVRGDLSSL TWVASPNKYW TQDTNDRRLC YVHYASLNFR
DIMLATGRLS VDAIPGTFLD RECLLGMEFS GCLKSGERIM GLLPCQALAT TVVADMRFVW
KVPESWTLEE AATVPVVYTT AFYALIVRGR LQRGEKVLIH SGSGGVGMAA IAIALFHGCE
VFTTVGSEEK KSFLKATFPQ LEDRHFSSSR TTDFEFHIMH ATNGRGVDLV LNSLAEEKLQ
ASVRCLAQHG RFLEIGKYDL SADSKLGMSL FLKNVAFHGI LLDSLFDPNN KEWSEVSRLL
VKGIADGIVK PLPATVFQHS KAEDAFRYMA AGKHKGKVLL KIRNEEPAGK ITLLSVEAVA
RSYCCPEHTY VITGGLGGFG LELSNWLISR GAKKIVLTSR SGVKTGYQAR YLYFWRRMGI
SIVVMTHDVS DAAQTAQLIK DAQELGPIGG IFHLAMTIKN YQESAKPKYW GTRNLDVQSR
KLCGPSFVVF SSMSCARGNA GQTNYGWANS TMERIINQRI ADNLPGIAIQ WGAIGDVGIV
QEKIGNNSTI VGGTYPQRIP SCLQCLDCFL SWRQGIFSSF IRAEIGGKNK SEKSGDAMQA
IAHILGISDL KQVDPDSSLG DLGLDSLMGV EIKQTLERDY DVVLSMKDIR TLTLNKLVEI
TTNATPTGKD RSVSVEMSAE QNLMMFRLNI DLNSLRPEKT VIKMNSVEEG RPVFLVHPIE
GVASSLEMLA SKLPFPVYCL QCTPEAPLDS METLALYYSE QIRTVCPDPP YRIVGYSFGA
LIAFEMANLI QEKNPDNPNA VLPLILLDSS HRYMTMYRKA YRMAYGVDSS SLMNDPRFES
ELLCAFCYRF SQADYKLLRH QLITLPSWEE RVSLVTEKIM EGGLFKDAEI VSFALNSLRQ
KFLAADRYSP TRTFRGDVTL VRSEDTIVRS EDIGNYYGLQ EVVTGKVLLH IVEGDHYSFI
HETGVDKTAA IITETIKATE
//
