ID   A0A0V0Y6J8_TRIPS        Unreviewed;       502 AA.
AC   A0A0V0Y6J8;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Lipase member H {ECO:0000313|EMBL:KRX95869.1};
DE   Flags: Fragment;
GN   Name=LIPH {ECO:0000313|EMBL:KRX95869.1};
GN   ORFNames=T4E_159 {ECO:0000313|EMBL:KRX95869.1};
OS   Trichinella pseudospiralis (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX95869.1, ECO:0000313|Proteomes:UP000054815};
RN   [1] {ECO:0000313|EMBL:KRX95869.1, ECO:0000313|Proteomes:UP000054815}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS141 {ECO:0000313|EMBL:KRX95869.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX95869.1}.
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DR   EMBL; JYDU01000050; KRX95869.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0Y6J8; -.
DR   Proteomes; UP000054815; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610:SF178; FI22312P1; 1.
DR   PANTHER; PTHR11610; LIPASE; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          58..380
FT                   /note="Lipase"
FT                   /evidence="ECO:0000259|Pfam:PF00151"
FT   ACT_SITE        203
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        222
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        308
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   BINDING         236
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         238
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         241
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KRX95869.1"
SQ   SEQUENCE   502 AA;  55187 MW;  8DD2CC6B824A7AFD CRC64;
     LLKTVNPNCE LTACTKAVMA LSAVVSGWLS SIIFTTTTLA AVVQNFQTNK PGEQLQRACY
     KDVGCFDNAG SFKHMKVLPQ SPNEINTTFL LFTPESKTNA TILTKTLLLS SAKTEQVNWT
     NDMFVLVHGF GQFPFWAAPM KDALVDQNNN VIIVDWTSGS IGPNYYQAAS NTRVVGAVLA
     DFVSTLVKSF KISLNRLTLV GFSLGAHACG FAGKNLGGLS LDPAGPLFSG KESEARLDSS
     DAEFVQCIHT NGQSFFKGGL GSVQPMGHVD FYANGGLVQS GCADGLEEII LDLFHLNGTI
     LEELTCSHSQ APVLYIETIK SSSFSQACQF TSVSCDSPSS WFQGKCFNCI ANGDLPAFGY
     KFKAQKQFKG QYYFTTLPKN NHHETYCGKQ YGFNIIPDQA VKGSITLTLM FNNLHSMNFT
     FQHIDETLEQ NNHAIKIGAV PEFYPKITNI SIIYEKYSSW IWKNGPDEWV LKSLTLLDME
     CNIHEVNPNI LVINKMATTV DM
//