ID A0A0V0Y7N1_TRIPS Unreviewed; 979 AA.
AC A0A0V0Y7N1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=orotate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00011971};
DE EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
DE Flags: Fragment;
GN Name=UMPS {ECO:0000313|EMBL:KRX96484.1};
GN ORFNames=T4E_8668 {ECO:0000313|EMBL:KRX96484.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX96484.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX96484.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX96484.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX96484.1}.
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DR EMBL; JYDU01000043; KRX96484.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0Y7N1; -.
DR STRING; 6337.A0A0V0Y7N1; -.
DR UniPathway; UPA00070; UER00119.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 2.
DR Gene3D; 3.40.50.2020; -; 2.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR HAMAP; MF_01208; PyrE; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR023031; OPRT.
DR InterPro; IPR004467; Or_phspho_trans_dom.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR00336; pyrE; 1.
DR PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00215; OMPdecase; 2.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF53271; PRTase-like; 2.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 2.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815}.
FT DOMAIN 748..960
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX96484.1"
SQ SEQUENCE 979 AA; 111193 MW; BA4393EAD28BF692 CRC64;
LSSCHLLLTT TSLMMDAKYE TFLTDLFHLG VIQFGEFQLK SNHTSPIYVD MRRMLSHPTL
LNTAEDFMYE YAKELEYDVI CGVPYGAIPL TSALSVKRCI PMIMQRKDAK SYGTKKIVEG
VYQPGDKCLI IEDVITFGSS IAETARVLRA QGLIVTDALV ILDRCQGASR NLESLGITKW
SLFLLPDVLL LYEDRGLISN ADCQRISSYL FNVTDKIAPS ALENGLQEGA KVDEAGVWSV
KAAKNAASLS HCLAKQLWEI AINKKSNLCV ACKLSDPKEI IALAQQIGQF ICMLIIRSDL
IFKHPLVDFI SDLKACAKSN NFMIMDDRKF CDVSSIVEMQ LTGGEWSIAN WVDFVTVLPF
SGRGVFSAIR QIKSENNFAC FSVLSLHAKD SLVPKEFSEQ SIKTAEEEID VVAGVVCSKP
PILDSRFLYL TAAGESDQAL LRVEDFDGMQ FLDVEYLEMN HGIQYADIYK VWACVVVKMI
DECKELLKKL FHIGIFKLET VVMRSVYETP IFVDFQLAIS YPEIMVCILL NERTCKCIAN
SYLEQNRRTG VFMFTSEVEV SQHLWCARRR FTTRISMRFI ISVKRNIPLL MYDKTKETTP
TGKVVDGVWK KSDKCLIVDD VLMFGHSLVD AANILRQNEL EVTDAIVILD RCQGPDNFLR
SNDIRRHYLF NFTDVLSYLN EQALLTDCEC LKISNHLLAF SDLAGKFIDQ CAMEKMIEPM
FLSLDRLSVI YHPNARRLWE IAYSKQSNLC LACDLCSPSE ILKLVEDVST NICSLKLHAE
IITISEMPDF FLRLKELSQA HKFMLINDGN YCDDSDVIIE LMMNSPIKPA AWADFVTVQC
LNGSSVFEAI EKVNKDYNVA CLPVIEMSTS GNFFTEEYKK RALSLAQQYR KIVGGFICQK
RPINDPSFLY ISPGIHYKRG MKDQNWRTPD KAVRFNRDDI IVVGRGITKE KFSRVWAYTY
QQISWDAFMI MDNAIVNRE
//
