ID A0A0V0YCJ2_TRIPS Unreviewed; 734 AA.
AC A0A0V0YCJ2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Diacylglycerol kinase {ECO:0000256|RuleBase:RU361128};
DE Short=DAG kinase {ECO:0000256|RuleBase:RU361128};
DE EC=2.7.1.107 {ECO:0000256|RuleBase:RU361128};
DE Flags: Fragment;
GN Name=Dgkq {ECO:0000313|EMBL:KRX97481.1};
GN ORFNames=T4E_5600 {ECO:0000313|EMBL:KRX97481.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX97481.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX97481.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX97481.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-
CC phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608,
CC ChEBI:CHEBI:456216; EC=2.7.1.107;
CC Evidence={ECO:0000256|ARBA:ARBA00001383,
CC ECO:0000256|RuleBase:RU361128};
CC -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase family.
CC {ECO:0000256|ARBA:ARBA00009280, ECO:0000256|RuleBase:RU361128}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX97481.1}.
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DR EMBL; JYDU01000031; KRX97481.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0YCJ2; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004143; F:ATP-dependent diacylglycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.200.40; -; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR037607; DGK.
DR InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR11255; DIACYLGLYCEROL KINASE; 1.
DR PANTHER; PTHR11255:SF54; DIACYLGLYCEROL KINASE THETA; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF00609; DAGK_acc; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR SMART; SM00045; DAGKa; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361128};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU361128};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361128};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361128}.
FT DOMAIN 64..202
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 411..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX97481.1"
SQ SEQUENCE 734 AA; 81497 MW; A42CDFC0409AD3C2 CRC64;
LFAFQARPFS AIGPIYFEYG SLVMTFNSPK VATKVCLKLQ DVSYEERKLL VLCLPNIQAH
MIPADVEPLV VLVNMRSGGC QGADLIRSFR KLLNPFQVFD VMNGGPLVAL YVFRNVPKYK
ILVCGGDGTA GWVLQCLDIV GQDSVCSSPP CALLPLGTGN DLARVLRWGS GYTGQEDPLQ
ILKDIIEADE VRLDRWTVVF HPQEPSSELS CALEQNPDRA LPMNNPEEQT SMIIMNNYFG
IGLDAEVCLG FDKARKLNPD KFNSRIHNKG VYARIGLKKM VNRKLCRDIQ RKIKLEVDGR
VFELPSLEGI IILNIMSWGS GSNPWGPEKE EVGFTKPNHD DGLLEVIGIT GIVHLGQMQA
GFSSGIRLAQ GGHVKITTFT DMPVHVDGEP QMLPPGTFTI LKSALKATML KKSKNKRRQT
TDANATTSTM TTTLQRESSS QAASLPSSLS SGPVLQAEPD DDYFLPLAYK TYFGRHDSSK
GSLIILHGLF GHKGNWRSLG AALSQKLNRK VFAVDLRNHG DSPHHSSMTV PEMADDVIAL
IKDLNIAGDQ LGIIGHSMGG KVAAHLALHQ PSLLGKLLLE DMIPKRIDQP QDKVLLCIKA
LNQCELPQMD LTKARQTVYQ QLFSVIKDAE TTHFLLTSLM LDKHGKPVWK FNISAIENNL
QEMFFYEIES KNTFEGPTFV VHGKRSDYVK PADVPFMLNF FPKLRFQCIA EAGHWVHADR
PSEFLSAAVD FFRR
//
