ID A0A0V0ZK80_9BILA Unreviewed; 671 AA.
AC A0A0V0ZK80;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 23.
DE SubName: Full=Calpain-5 {ECO:0000313|EMBL:KRY13111.1};
DE Flags: Fragment;
GN Name=tra-3 {ECO:0000313|EMBL:KRY13111.1};
GN ORFNames=T12_8648 {ECO:0000313|EMBL:KRY13111.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY13111.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY13111.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY13111.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY13111.1}.
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DR EMBL; JYDQ01000147; KRY13111.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0ZK80; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF416; CALPAIN-5; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 31..353
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 513..630
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT ACT_SITE 86
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 257
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 294
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY13111.1"
SQ SEQUENCE 671 AA; 76070 MW; 762CB80F25300221 CRC64;
LANRKENMAP EPFQNQRYKK LKKQLVKEGK LFTDLEFPPT NSSLYYDPKR NEGIEWKRPG
DIVNNPKLFV DGVSVNDVTQ GVLGNCWFVA ACSALTRHKR FWTKVIPDAN EQEWSSSRAD
KYCGIFHFCF WRFGRWVDVV VDDLLPTRGG KLVYAQSKTR NEFWCALLEK AFAKLNGCYE
SLSGGTLAEA FVAITGGVPI TIKLDSGIYY DHATARMELF SMLKKAFNEK ALMAVSIRAN
TLEEVEEPLE CGLLKGHSYA ITEVKKLSLD SRYQSLFSSL FNTPEKVMMV RLQNPWGEKE
WNGAWSDGAS EWDQISKEQQ RELGLKIEEN GEFWMCWEDI CTNFTTIDLC YQFDTSVFSL
SSRYHETILH GVWHCANDKG DVLSDRAGGC ANFKDSCLQN PQYRLDVLED GGEFVASLMQ
RGSGIRRRQR TSYLTIGMIL IKVEENRIYR LHKLTGQIVA KSDYAGCESV LMFAKNLRRG
RYVIIPSTFA PHEEGEFMLR LYATWNMQAT ELTLDGPAPN PCSCFSKPFK CVTQLTVVGA
NNLHVSNKGP INPYCVVKCD GREVRSMICK ETRDPNWDLQ CIFVRKSVDK PIQIDVWSSN
MVRRDAWLGR VLLNCPINNR CSSGEQPLEE KAKKAAAADV NTSTGAPASA VDDKQGKILY
SVATYDDPIR L
//
