ID A0A0V0ZRM3_9BILA Unreviewed; 4066 AA.
AC A0A0V0ZRM3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Spectrin beta chain, non-erythrocytic 5 {ECO:0000313|EMBL:KRY15103.1};
GN Name=SPTBN5 {ECO:0000313|EMBL:KRY15103.1};
GN ORFNames=T12_10525 {ECO:0000313|EMBL:KRY15103.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY15103.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY15103.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY15103.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY15103.1}.
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DR EMBL; JYDQ01000102; KRY15103.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd21194; CH_beta_spectrin_rpt2; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 19.
DR Gene3D; 1.20.58.60; -; 20.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 28.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 30.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 75..192
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 209..314
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 3748..3856
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 4020..4042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 812..839
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1073..1100
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2133..2167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2569..2596
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2678..2705
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3341..3400
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 4020..4035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4066 AA; 470832 MW; F3099E3A94BB1A57 CRC64;
MLSHHRCRLW SNSGMDSFVA DDNSAFFLHL FFSYLGKMNE EYVSNENFDE LMDSKEAAQF
FERGRIKQLQ DERVSIQKKT FTNWCNKYLD SIPKEYDEET MSFRSPLHVN DIFVDLCDGI
VLMKLVEIIC GENLGRPNRG RMRVHKIENL NRVLGFLKRK RIPFENIGAE DILDGNPRLI
LGLIWTMILR FQLDDIVIEV EGPESGEKKF AKDALLLWCQ RKTAGYRGVK IENFSTSWRS
GLGFNALIHA HRPDLINYDA LSSRDHLANL KNAFDVAEHS LGISKLLDPE DMDVARPDDK
SVMTYLISYY NYFAKQKKGL TGAKRVAKVI AQLMSCENKE KEYEGIFSRL LEWIERKIAE
LGSRRFPNSL VGIQEELFKF KQYRTQEKPL KYIEKGELEA LIFQIRTEQQ GLGTKQYTPP
NGYLLKDIET AWNMLEKAEH ARQIALQEEL IRQKRLEQLA RSFECKALLR ESWLREMMMV
LREFNYGKTV GEVEASIKKL EAILADVLPR ENRFQSLKAM ASELVSENYH GKTAICQREQ
SVWGKWLNLL HELESRRVAL QSLSKVMSIL RDVDALAQEF SEIEAILRMR DTGKHLIGVE
DLQQKHNLVE SQLLTCGGRL KTIVADTQRY SRCKEVEFEV LQTKVAELQH YYDNLLQWAQ
MRKLALEKAN ELFRFLEDVE EEDKWLLEKS RFCITLVRNC DLSFSSQLNR LLKCLETEMQ
AHWVRTKKVM AVGEQLLLNT FPDAKEDVQN GLKNLQFRWD ELRQLIAVLG RYVNEARQIN
QYFQEANEAE SWIRERMPLV SSEDAGKDES SAQALLLRHS RLEEEIKAYS GDIHRLDEMA
QELSSSEMLL NFGKGDKNDL QSIETSGRNL LEKDESDEAR HASKIICRDD DASVKTASLR
KKSLGQNEVN VINDRQQQIN YAYGGLITLS RDRRAFLEEV VQLHRFYRQC YEFQLWAKQM
GKALNEPVSS EHIKASRRKY DKLVSDMNTN GGIRLNEINK MAEEFTASGH GHIDRIRDGQ
LEVNNTWESL LKLKAAKADA LNAAERVAEF NEVCKETRSW ILEKTVVLEE QTEANDMKSL
QALQRKHQNL ERELRPVEGK MQTLQSLAEN VMKAYPSEAG SVRSELKALQ NMWIELKDKT
ARRRVALEDS RGWQMFQNAV EDLTTWINKT KSTLSVMETA VGVSEANALC LQCEEIWRDI
INHNDELNYV NDLGKRICAK GHMKSEVEDE LTKVNANYRK LTEYCTEKRE HFDDMLQYWI
FVREADVIDS ATKGLEALLK LHDVGNSVDA TDDLLKQSKE LDTKLQAQNH RLEEFLTNSE
LYLEKRPLNE KLIRERVSEV VSYRDKIKQL AAHRHAELEL SLVFHLFRRE VEELMQWIGE
KMRIVSSDSY HSGLNLQKRI KKHEAFEAEL HANQDRLTRI NKKGMQLVER TINGSEVNKL
LENLNEEWEK LLTLTAERGQ KLKHAGDQRV VNRMLDDLTF KLTDFQQKLE SEDVGSDLRS
IKQLIQNHTV LVQDVKSCAC QVDGFVSHVE EFVRSGHDGA ERILNNVLDL KEKYRLLEAP
MKHRRDVLES SLLMHQFNFD VECEQQWIRE KQSAASQKDV GRSLTDALNL VKKHEQLESE
VSGHQPIINR VLEFGRNLIE KMHFAAGEIS QRCDLLSEEW KSLKKDISER HEKLELALLV
HEFYANASDF ESWMNEKRCF LNSDDIGTDE NSAGVLLMRH KAIQDELKLY RSLFDTVKTQ
CERLKDKGYT DMKGEQERLE DQYRQLEQLA ERRIFILTEA ISMYQYLRDS EELERWINEQ
MAIATSEEVG KDHEHLVDVL SKFDDFRQRV KHASERFIMC DNAARSILER QPPFSGTIIT
RQDRLRAAWS SLLDSVELRE KKLEAAAEIH RFNRDVAEAL SRIFEKLESI PTDLGKDVGT
VQSLMRKHDA FENELIALES QIQVVLDDSG RIQSDCSPSQ AEHVISQQKL LVENWNRLQA
LSDCRRDSLA ASYDFQNFAA MARDFIQWTQ QMIAQMRSNQ SVRDLQSAEL LLAEHKQLHV
EIETRDDDFN RLEIVAQKML SAKHYASSEI AEKRDQVQQA RENACNEWAS KQRWINELIQ
LHTFLREAKQ VMTLLGSYDV SLNSEIPATV EGVTALTRKH DTFEKKLNAL EDRVINLKTD
VAQLVERKNV EAQNMQYVYS TLEKRWRHLL QMSDQRRAAL KDAMMFANFK SDIAEVESWI
NDRLQTLNAN ESSVKNVSLQ EKVKLLQKHQ TVEAELAFHR PRIEQIYHTA NVLLKQGHAN
RDEVKSCKES IQRKWGALES ACQEQSLALE EARDILNFEQ LIDNVTAWIR ATELMVQAQD
MGNDYEHCES LLKKMVDAES EANVDEDTLK RIKSIGEKLV VLGRSDAEEV RGKVENLQLM
WTSVQQSLAS YREQLEAAKV VHAFNRDVDD TVQRISEKYA TVTADEHMRD LLAVEVMLRN
QHALERSSGA LYEKIQCHRA VAQSLLTQNP PLKCFICDLE IFDLQDTIEE SCKKLETSWT
RLEQASKERR FRLEQCQDLF KFFDRQREIE QWSATMRSKL VLHHVPHSVS EAQQLLENYK
EKRAEIVGRR EHIEQLKHHG AQLCQKQQDH ASEVSEAMQN LDKIYSTLLE QWENENVRLW
RWYDFQNFSE HANMVDEWLS SKEVFLKRNN FGDSLDEASE LLKELDRFET TLRAQSEKID
KLVKNAEENS AKDAEHAEVI HSRSTSAVQR YDSILEQCSK RREALKDYRR FKLFVKDSHE
VMFWLNAKLQ IAYDETYVDS THLQSKIRKH DAFEAEMKAN ESRVVAIVSE ADSLLAGNPY
SRETILLQKD EILNGWKELT EVSKRKSERL RDALKSYEFS RLLADLDKWI DGIETQLSSD
DHGSDLNSVE NLLKHLEQLE KDIKARKGDF EAVKVRSAEL IAKDDVANFE ELLSKSRAVV
ERYVYLAEPC EIRKENLQDS HALYQWMHDV DEQSDWIREH RPAVFSEYTG ESLQAAQSLL
KKHQQVEQNF NTVVASQQRL LAAGRLMVQR RHYASEKIVA KIDIVEKELH QFREQLVVRR
QKLHHAIQVQ QYYCDAFEVE QWMAEKQALL AGDDQQCQDE EAVLAALKKL DLYEQDMQNF
HTELRSLGEF LQRILNDNHQ QQQQQEHDQS TAMSAKQAQL EREYETLVGL CQQRRRRLSD
SGHFYQFVRQ VDTLVPLLRQ KEAVALSEDY GRDLDECKAL IGQFDQFLRE LSSLGERVAS
VQRTHDDLLR ASHPFSASVR AAGADLQKLW HDVNEAATER HQALLGAKQV HEFDQEADET
LNWLHEKEAQ LVSESTHDFG QLDMKTIKAQ LQRNEFFLRE LSAVQRKVET LCKEAERLVS
NYPDTAEHLD VRKQEMMEVF NELNQEGKNQ RTKLEHAEQL QAYFEQFHDL INWINGMQTM
ITADSLVKDV PGAEALLLRH KERFAEIEAR APAVVEFIQL GKEMMRSKHV LSLEICDKVD
QLDTAFNNLR LIFEERSSLY AMNLDAQIWK SDASSLEAWL NDRQLYLKED WDGIKSAREI
EESIRQYDDF LTTLSAQEEK FDALKKLTLL EQAMECQSMR EAQVQRQVEL SREKQRKQKV
KTLEKHRILQ ERRQERERRR TQEISYTKSL SSETASIQRR SSISFVPSTL VYDNGNLEQT
ATSLGTLSSS TQAFSSVTGT DSNTRNVTTV SKSELSDATS TFKCLSTDDS TNPSRYSINS
ESVVESVKKI PSFTTRRGMR RTAPSNDMIE KKGYLERKQD LQSGGKKATI RSWKNYYTIL
CGQLMCFFKD QQGFCSGAAA SAPINILHAV CQPASEYQKR KNAFKLRTVD GAEFLFSASS
FSEMQDWIAK ISFHASLPPS MQLKSFREHF DQLSQSVSKS SNSSATDVYF TCLTHPSIAA
STAETLPTTA PNDDSSYSST WQMTDDSSKY FTALSEPTVP PSVDENLNTA SLDVIHEEID
ESALNFVKTR NASSTDPATA EASENGYSLQ TALQYSENSS ELDTGTSENC TESYIHSEDV
AQRQQSYQDT ASSTVTVESE EKRRKLLPRI SSLFKSKKRD TKDMQF
//
