ID A0A0V0ZTF0_9BILA Unreviewed; 1730 AA.
AC A0A0V0ZTF0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN Name=Polr1a {ECO:0000313|EMBL:KRY15883.1};
GN ORFNames=T12_7001 {ECO:0000313|EMBL:KRY15883.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY15883.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY15883.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY15883.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY15883.1}.
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DR EMBL; JYDQ01000088; KRY15883.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02735; RNAP_I_Rpa1_C; 1.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.357.120; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR047107; DNA-dir_RNA_pol1_lsu_C.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 332..665
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 1404..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1471..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1730 AA; 196683 MW; A65F8330AAD189FA CRC64;
MFIMVQQFYG DTMLSQKLKC QADCNTLNSA GFDILTPEEV LEISVKEITV PNAFDALYHP
IAGGLCDPAF GPVDYMEYCA TCSFTGAQCP GHYGHIRLPL PMFNPLLFDI TYQLIRGTCF
VCHRLFVADN EVALKIFFAQ MEALDEGNLA LALEIAEIST EVFSELCVSD SPNLQNLNNS
ENSVKKNMLK ERLEELKKNR KTNSKGNLEI TKNVSQVRRE LISEFCTNFL YRRIKQCPSC
ASQVTGIRNI GKRAVILTLP SKKGILKKKS NDSLKNNNKY AHGNQRYVSA AEVCSHLQMV
WKNGGENILS SVFPMFKPRK NVQYADGFIP TDLLFLTHLL VMPPKFRPIV ELAGRKCDNP
ISQIYRNIIE DCLSIKRFMQ KATADKWQTE DSESVDAVQD SEEQIQTLCL TMQSHVNELY
DNSETSRIAS GLTVQLSARG LRQVLEKKEG LFRKHMMGKR VNFAARSVIA PDPYMSVDGV
GIPEVFAKRL SFPEAVFSAN ATAMSEAVLH GPDVHPGANF IIDERGMKIY LNAGKEIERS
GMAKRLLQTS QRFGIAYPKK VCRHLKENDF VLLNRQPTLH KPSIMAHKVK VLKNQRTLRL
NYATCKTYNA DFDGDEMNAH FPQNEIARAE CSEIADVARQ FLVPKDGKPI AGLIQDHVVS
GFMLTMKDKF LTKEDFNYLL LSAFPSVEHP WRQVPPTIFK PVRRWTGKQV VTTILLNVIP
SHLPPINLVT KAKTSIKNWT VPGKRNPIFE LSESNVVICS GELLCGVLDK AQMGASPYGL
VHCIFELYGP AVAAKLLSCF SRLFTTYLQM RGFTLGVEDI MLTRKADSKR RKLLSTVDRC
GSEAVREALA LDVGIEDDEV KLILEKMHFK NEKESLLRVE QCFRQATDKF NDQANKVCFP
NGLLKSFPDN GLSLMIETGA KGTSVNFFQM SCMLGQVDLE GQRVKVGMSG RTLPCFQRYD
TKPRAGGFVS QRFLSGVRPQ EFFFHCLAGR EGLIDTAVKT SRSGYLQRCI IKHMEGIVAN
YDLTVRDADG SIIQFYYGED GFDVTKSQFY DNTHLPFLHA NIDVLEQTSG DLPNFENEDN
LIAAKRFSKI KRWKEKYGKC PEVESMHKSQ LALLPNVNED SSNVDKEQLV AAWFEHPVEE
RRRWLRQSVK WRPDPVMSTL RPTTCIGALS DKFLEQLDNF IQQRQARVDE SVHKFEKLMK
LRGMRSLVEP GETVGLLAAQ SIGEPSTQMT LNTFHFAGCG EMNVTLGIPR LREILISGSA
TISTPTSRVQ FRHGVSRELA EDVQRRMNRI VLNQVLEFAN QMEFVTTDGY CSYCCILRTG
WYSRLLIDAN FFHRAKYREY EITLKLSKRR KRPHSVRHLD SRTVMAKIEQ GFFRSLCFSL
KKMFDSGNKF REVEMFHIEN ENEINENEDG LTFAGGNDQD SSEEEDDNDV DAVEAQQRQR
HKDDNEYLGE DEEAIELNLF TSGENCLFDS TGNEGESVVQ QNNSSEEIRP GKDDDDDQHL
PLDQYRVKMV VEQDSLITDY RYDSKRNHWC KATVKVPFKY GAIDMRYLVE EECSKFVVQS
VRDIKRCMLT EQNGELFLIT EGINLKVFTE RPDIFNVDRI YCNNIHTMAS MYGIEAAAQS
IIRETKNVFA SYGIEVDHRH LSLLSDYMTH TGKYYSFSRN YMNSSTSPFQ KMSFETTVNY
MKEALTRRTL DTMQTPSANL VVGRLPRFGT GFFDVLAPLP NRNVEAEAEQ
//
