ID   A0A0V0ZY61_9BILA        Unreviewed;       264 AA.
AC   A0A0V0ZY61;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE            EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN   Name=SPHK2 {ECO:0000313|EMBL:KRY17118.1};
GN   ORFNames=T12_614 {ECO:0000313|EMBL:KRY17118.1};
OS   Trichinella patagoniensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY17118.1, ECO:0000313|Proteomes:UP000054783};
RN   [1] {ECO:0000313|EMBL:KRY17118.1, ECO:0000313|Proteomes:UP000054783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS2496 {ECO:0000313|EMBL:KRY17118.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC         EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY17118.1}.
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DR   EMBL; JYDQ01000067; KRY17118.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0ZY61; -.
DR   STRING; 990121.A0A0V0ZY61; -.
DR   Proteomes; UP000054783; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.200.40; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR   PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:KRY17118.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW   Transferase {ECO:0000313|EMBL:KRY17118.1}.
FT   DOMAIN          40..192
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
SQ   SEQUENCE   264 AA;  29384 MW;  36FED845E5998CC6 CRC64;
     MNYKIGLPCS ELMHAKKKFT FTNNVDLVVD SPEMNETAER NSHNVAVFVN PASGTGHAHS
     VFQRKVLPVI EKAGMTPEIF ITGKDDETEK KCKYLNISKY EKLLIVGGDG IIHELSVVLE
     ILNGLITRSD WDEALQLPIA VLPCGSGNAL AASAFSLPTH KMNKKELFDA ALNAVVNGAP
     HRLKLIHVTS NMFSCYSFMS VSWGMIADID LQSERFRYIF GRNRFTVEAL FKIVHPKTCR
     GKLYYLPYGN DVDGGDDFHD NGVE
//