ID A0A0V0ZYP0_9BILA Unreviewed; 1113 AA.
AC A0A0V0ZYP0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE Flags: Fragment;
GN Name=Ptp69D {ECO:0000313|EMBL:KRY17808.1};
GN ORFNames=T12_1181 {ECO:0000313|EMBL:KRY17808.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY17808.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY17808.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY17808.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY17808.1}.
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DR EMBL; JYDQ01000056; KRY17808.1; -; Genomic_DNA.
DR EMBL; JYDQ01000056; KRY17811.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0ZYP0; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF543; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..211
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 349..468
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 741..1007
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 924..998
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1038..1113
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY17808.1"
SQ SEQUENCE 1113 AA; 127242 MW; AF0E442810F44AFE CRC64;
LMASRLFCTL PNLLFLLCFG VQYVLFVASV LEEEMCEKTD DCVVDGQCLL PHDNADANGT
RFCFCSKSCI SSVPVECSRH KQCVVDSVES THQNFCDKEK RLCLCRARKD NEHACLKKNL
KIIYLNTTRS SVYLGESFKI TCCVNIEPRS VRFRWFHNDT EIPSTLYPDL FQLCWTLNVT
NARFADAGSY TCSVKTDAHG NAWLNASVDV QVRGSRFFAF VREMDGQHLA VTKSTVDRPN
VTESRSDNST NFFLMLNATG LNEATILLDW VANPASSAIK FRVESLDEEE FAIEDVISAD
SKPHIISGLK PASHYSVSAE TVPGRGRRPV YDKVVVQTLD KGIQAFPSPP QQVNMRMKDE
IIRTKCELSW MAPQVSNGPI LYYMVDVYGV IRRKSISQVN KMQKHRPKSV NCQNLNRVPP
KDSFMQCEFE GLLPNHNYSA RVVAVNALGE SPPSMVNSKC LTSYGPPPHI ETPIAEKRFD
DKTIRILFSS VPDDIYGPIT CYFLAIVPCT RNYNMSQLPH PVYMNFDVYE RTMQSNLHIM
FQPIFAYISE AFYSLPRETI IGDGRQTVGD VSSTLEFLGR FPAQDGELQR GYKYTGFLIV
RVDPDNLVYN LTSNGKRELL QNWLQPTYGF SNYFKPVFLG ESDVLITEDQ SRGYQETIYL
LAVGFSVVSV LVVFGTVLCF YYSHIRGWLK TLLCVETNFV PDRNSFADLQ RVAKRRDFQP
TAVEDLPNEY LLRHRDSNFL FTVEFESLPN YNFDTTASDK LENAPKNRYN DIKAFDITRV
KLERVDDDSS SDYINANYVQ GYKGRKLFIA AQGPTLDTVN DFWRLVWEQN VNVIVMVTNL
QERYRTMCIK YWPEHSPSVY GRIEVKPLDC TFYADYVIRN FTIRRCRTTA DESESNNLLN
GDCRSIVQYH FTGWQDYRAP EGSYGFLRFM KQFKRIDCTS DCPVLVHCSA GVGRTGTFVA
VDSMMDQMAE EGRVDVFGFV SNLRRQRNFM VQSLDQYVFI YKALAEWYMF GDTDVDAERA
EEYVVELRQT LNNDSTGLEK QYNLLFRSLE DALTCNYAKK SFNEQKNRFK TVVAYDRNRV
ILAPRLGHED ATYINASLVR VSGRSVIVGG NGN
//
