ID A0A0V1A0C5_9BILA Unreviewed; 2157 AA.
AC A0A0V1A0C5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 13-SEP-2023, entry version 23.
DE RecName: Full=Trehalase {ECO:0000256|ARBA:ARBA00019905, ECO:0000256|RuleBase:RU361180};
DE EC=3.2.1.28 {ECO:0000256|ARBA:ARBA00012757, ECO:0000256|RuleBase:RU361180};
DE AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN ORFNames=T12_13994 {ECO:0000313|EMBL:KRY18315.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY18315.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY18315.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY18315.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC Evidence={ECO:0000256|RuleBase:RU361180};
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY18315.1}.
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DR EMBL; JYDQ01000048; KRY18315.1; -; Genomic_DNA.
DR STRING; 990121.A0A0V1A0C5; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.20.25.10; -; 2.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR019761; DNA-dir_RNA_pol-M_15_CS.
DR InterPro; IPR001529; DNA-dir_RNA_pol_M/15kDasu.
DR InterPro; IPR001661; Glyco_hydro_37.
DR PANTHER; PTHR23403; TREHALASE; 1.
DR PANTHER; PTHR23403:SF12; TREHALASE; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF02150; RNA_POL_M_15KD; 1.
DR Pfam; PF01204; Trehalase; 1.
DR PRINTS; PR00744; GLHYDRLASE37.
DR SMART; SM00661; RPOL9; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 2.
DR PROSITE; PS01030; RNA_POL_M_15KD; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361180};
KW Hydrolase {ECO:0000256|RuleBase:RU361180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2059..2081
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 488..542
FT /note="DNA-directed RNA polymerase M/15kDa subunit"
FT /evidence="ECO:0000259|SMART:SM00661"
FT REGION 1246..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1780..1817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1800..1817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2157 AA; 248465 MW; 154DFE4D93CDF410 CRC64;
MWTFSEHTYY EIKKHFKFAG YFTDFRFNVE PGLAWFARRN IRFASEIKKM PQHSILMFRL
FCLFSLELLR SVMGDKPVTP QGSFFRVYSQ DRQYRDLAMT GDKASKLACG PTKRAFDHDV
VWATDHPAAG PLLDELVDAM VYAKCDVNVP DDANMSVMMT LRAVNMEKPQ IKQDAASGMR
SSALDPERMK SVLQAMQKSG AQGVSQDNID RALQLIELAL KEKRAISIHE MEEVLRLVEF
NVFIGADGLK QMFERLVNDK TLTEGQANGI LQPLLAKAAS KADGKLPMQE IIFFTTLPTL
GWCMSTPTNL HYLFKVMQRS GAQREAKDNI DRALRMIELV VKEKREISIQ EMEEILCMVE
SNVFIGIDGL NQMFEYLVNK KTLTDAEAIG ILPSLLAKAA AKAQKKIPLQ NVREALKNFM
TVKEYFFFIF IFYSIYQESS LSFQNYRTNI KSQCNYSTTV RLYSVEQLNK LKVEQKAHVD
TLKHPGIIFC PECNNILYPK EDKSRRCLLY ACRNCSYVTD DIVSVCVYTN KLRREIDELA
QVNVDVIYDP TLPKTDDHSC PLCNNSEAVF FQSQNTKAEL LLLTYCKVVR NLICQLFGHG
AWLRGKIECV TIANALCRTS FSGTLKVERI VAAVHCCRWV SGAFGFEKNT KPNNKVSLDK
MMYYVVSLLS QIYCQGPILD AVQTAHLFPD SKYFVDMALK KDPITTLQNF ISLGDRVKDK
AVLRAFVDEH FDPPGTELET CFPEDWKPSP KSFNVIKDYE FRRWAVALNR IWKELCRRVK
SKVFEHQELY SLLYVPNPFI IPGGRFREFY YWDTFWIAKG LIASEMFTTL KGMIRNLGYM
VENHGFVPNG GRVYYLFRSQ PPLLIPMVYD YYLATGDIDF LQEMLPLLEQ EYGFWLLHRG
MTFGDDSNNY MKLFQYKAEM KMPRPESYRE DLELVQNLTD DHAREFVWAQ IVSGAETGWD
FSSRWFSHTG PEAFTLRSIR TWSIIPVDLN AFMCMNTKLL ANLYEMAGNV TKVLLYQARF
EQAKAAMKQI HWNEQDGIWY DYDLETKRHV DVYYISNVLP LYAKCYDDED VPSRVYNYLK
TVGALNSTRG VPTSFIQSDQ QWDSANAWPP MVHMLLEGLR TSGDPEIIEV AKELAIQWLR
SSYDAFLKTN SMFEKYNVSS TAGEMPFGSG GEYEVQTGFG WTNGVILDLL VKYGDVITAQ
DATTGTINYW KYAAYVVFVM KSELKQDEHA LKEEILGFMN KIGLKKDGKN KNSSRISTPV
RRETKRTFNN NGKLIFSGDS AWNNNSSGSK NKQQQQQQQQ QRANKLLPTK IKTEDLNEHP
VSESSVQRWF DAKFTDVVGS QPLSEHSLMK MEAYAKQLFQ NQAVNYEKET MNKKNNSNQL
RWMNSVASGG TLSDRVAALG MLVQQSPLHN LKHLDTLLNK VTKKNRHEAL IAADVAKDLF
IEELLPDRKL IPFKSRPYVE IENTKGQSKA AVDRKLLLWQ FESELKMKYQ QFVHALEQLC
HDTVEAVRLK GCILLVDLLI AKAEQEQFIL SSLVNKLGDQ SVKVATQVVK LIGRLFLAHP
NMKVVVVDEL EKLIYRKNIT PCAQFYAICA LLKVPLNRNN DEDLACKILN VYFDLFKIVI
QSDVENQRLL RHLLLGTNVA FSYSKGKFDR ISEEVDTLYK IAATSSLYIN LQALALLFQV
LDVKAEISDR FYRSLYRTML VPELLSSSRC HAMFFHLLFK SMSQDFSDQR IRAFVKRLLQ
VCLMAPAPFI CAALLVISQA LHGRLKRFVA IADQWVEDDH EEQEKVDDEE EKEIGNGKKK
QTSTESNNTN DNKQNANNIY GNVYGSREYN IAGREPLHAN ADRESLVELL LLRNHYHPTV
AVFAENLLKG NHINYSGNPL DDFSLMHFLD RFVFKNPKKS ISENVEEKNT EKRGYKRKIY
DPWSLRSLPV TSSAYALHHK SHVPPDEKYL HSFMTNANVK RAEEQLSEES DDESVNSEEF
EILLDKMKPG SKNEEFLVDF SRQVRITVSK FVRRYNDVPV KLETNDDDGG RNVLKIRMIL
IIHQILLEMN PILKRVDQSL MILQPLQVTM MIVLTAAYWM MMMMMQQLLR KSSVKFWKMT
MKKMRRKSTT VNEKRTRNFK KFVNDDGVDV DEQADVFFSL SVFIKIYFGK IAGFWML
//
