ID   A0A0V1A1V1_9BILA        Unreviewed;       976 AA.
AC   A0A0V1A1V1;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE            EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN   Name=MAN2C1 {ECO:0000313|EMBL:KRY18847.1};
GN   ORFNames=T12_16820 {ECO:0000313|EMBL:KRY18847.1};
OS   Trichinella patagoniensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY18847.1, ECO:0000313|Proteomes:UP000054783};
RN   [1] {ECO:0000313|EMBL:KRY18847.1, ECO:0000313|Proteomes:UP000054783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS2496 {ECO:0000313|EMBL:KRY18847.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY18847.1}.
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DR   EMBL; JYDQ01000042; KRY18847.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1A1V1; -.
DR   Proteomes; UP000054783; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT   DOMAIN          476..553
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   976 AA;  110915 MW;  D4C6B165E844FD48 CRC64;
     MNYPFEQAPF NEAMKEIEKF GEDVEVGFEM SPTWATYWFR ITCTIPNDWI GEKVCFSWDS
     GSEVLVWNSN GTVSQGLSGD AGRTLYVLSN KVEPDQLEYI FYVEVACNTM FGAGSDDTIA
     PPNAFRKFFI KKAEIVVINE EAFQLYMDFD VLNSMISSMP ADSPDRYKAL YTANMMVNMA
     SDMNKESIMK AHALAVGFFC NKENCPLNFT VQAVGNCHID TAWLWPYAET KRKCARAWSS
     TLRLMEEYPD LTFACSQALQ MRWVQKFYPD LFAQIVKRVH EGRFVLVGGA WVEHDGCLPS
     GESFVRQLLY GQSYFKENFG VTCTEAWLPD TFGYSGQLPQ IFASAGMRRF VTQKLSWNVV
     NKFPNSTFLW EGIDGTSVVA HLPPGNSYVM ENTVSDVFKT MANFQDKGRS ETALLLFGKG
     DGGGGPEREM CERLVRSQRL PGCPAMKPTT PASFFEDVEA TDMQNLLTWV GELYLEMHNG
     TYTTQAEVKR KNRKGEFLLR DCEMLAAMRF VLDSGGDVRS FYKEWLQLLQ NQFHDVLPGT
     CIALAYVEAN RMYQQLTSEC ENYLDESADG EFLMNTLGWS RRLITETDAY LVPAFSVIRK
     RDAVCKIDDR VHVEQIDELI VMKNKFVEIA IDDRGRVVRL NLPDHCNVIA DGMPGNQFTM
     FDDVPLYWDA WDVMDYHLET KRLLTNVTEG PTFGISENGL TAWVEFTLQI SESSNLKQRI
     VLQAHCPYVQ FDSSVIWMEK HKFLKVQFPL NVRSQEATYE IQFGHLSRPT HRNTSWDSAR
     YEVPAQKWAD LSMYGSGMAL LNDCKYGYSC YKNILVLSLL RSPKRPDPDA DIGGHKFSYA
     IMPHCGQFQR AVHPDTVNVI QASYELNCPI RVLKAPFVEN STVWDRQFSL LTIENPAVIL
     EAVKVSESGD RLLLRFYESF GGQAETTITP LAFGVKSCFT CNSLEIPDKP VPLNHSGTFQ
     LQFGPFQIVS ILIEII
//