ID A0A0V1ADL1_9BILA Unreviewed; 4769 AA.
AC A0A0V1ADL1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Protocadherin Fat 1 {ECO:0000313|EMBL:KRY22935.1};
GN Name=FAT1 {ECO:0000313|EMBL:KRY22935.1};
GN ORFNames=T12_3370 {ECO:0000313|EMBL:KRY22935.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY22935.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY22935.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY22935.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY22935.1}.
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DR EMBL; JYDQ01000006; KRY22935.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 27.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 29.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF310; STARRY NIGHT; 1.
DR Pfam; PF00028; Cadherin; 16.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 27.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 27.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 7.
DR PROSITE; PS50268; CADHERIN_2; 25.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..4769
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006874475"
FT TRANSMEM 4261..4282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..150
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 151..261
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 587..687
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 688..790
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 791..896
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 897..1003
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1004..1109
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1110..1224
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1321..1427
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1428..1588
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1684..1812
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1899..2023
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2035..2128
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2129..2235
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2236..2354
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2355..2472
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2473..2576
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2577..2792
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2793..2902
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2920..3038
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3023..3129
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3130..3239
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3240..3358
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3359..3470
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3487..3581
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3849..3888
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3900..4074
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4111..4148
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4150..4186
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4195..4240
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1457..1489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4080..4099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4305..4352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4615..4642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4706..4769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1482
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4331..4347
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4623..4642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4734..4748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4749..4769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3858..3875
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4138..4147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4176..4185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4230..4239
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4769 AA; 528258 MW; 371F6E18FFA22791 CRC64;
MLSFGFVICC LHAFHSVVST TNSNSSTNAV TFEFTQSTYV ATILENTRRK VYVQPTSKMG
IYLSPDLKGH VRYRIISGDA EGFFKAESVV VGNFAYLRVH TKSLLDLSLN RESNAQFELV
VRASVREIKR ETSARLLIKV IDENDLAPIF QPDHYSAVVD ELLEPFSVVV KVHATDADEG
LNGEVYYYLK EASSFFAVHY VTGVLSSVRP LHSLAGRSVL LTVVAEDRAA RLFADQVPAS
RPNVALVNIT VRPAAAMEPC QLSCQAVASG CDVVQKRTCA ICTLSRSPSS EIGDRIRLTG
HYSEYFVAVR DDANASLYHL MLNVAEIPSD SYAIQLHIDD SSGSELVSAD CKVTVNSGRC
PSIANHPERV NFTVDGTSPD RTIVGFVSPL SLVDSGQYRW QMLKGVHSSS ESFEIVQSTG
LLVVRHLSAA GWYRFNVSVE SKTCKQKLDV ELELLVSGGN FHKPLFQLPP RCSHVANDGQ
LCHFEASDGD ENGNRSLFYS LVNTDAGRWS RLELGSVDGV LRLTGSKNSN QSTEVRVRVT
DGQRPSRSGD LLLRFDSSWQ LVSFEPVEWP SIDDQREPRF LHLPYPEVTV FENATIGLTV
FQFQAVDQDV GADGLVTYSI IDGNEDGRWR IDPNTGKLTV QRSLDREQVP RYNLTVAASD
GHWPEALVSL SSLLIHIGDS NDQRPVFDRL LYHAEVDENA ALSSPILTVR ARDQDLGSNG
RVRYKLLTNG DQFALGSHDG LLTVIGQLDR ERRRRYDLLV QAIDSGSPPL SSFARILITV
RDCNDNAPKC VVDEQRVSVR EDVPPYALLT CVEAFDEDDT EANRRLRFEI QVGQKFSIDA
ETGCLRVADD GLDFHAQVEH RLLVSVRDSG RPSLNTTCTV VVDVDMVNQN RYAPQFDSFA
YNADIYENEP PGTVVLSLKA KDPDAVDWLK PSILYSIVGG DGWHYFAIGE QDGVIVSRIP
LDRETRSYYW LTVEARDRAP VSLATRVDVF VAVKDRNDNA PVPARPLYEA DVVENSPPGT
SIVQLNATDF DEPRSPTLTY SIREGNAQSL FQIEPNTGLI YSGDRRLDRE AVSVHQLEVE
IRDGGSPALT SRTLVLIRVL DENDHAPQFG SKLYSFNVPP CTKTGQLLCR IFAVDPDAGL
NGTVSYSIVH QEGNSGGDNG RVQLDPNSGQ IYCSRVGSTH WYGQLISLNV EARDSGSPPL
SSRTRVVIRF VPPADHLLNT APVLLSNANL QLDLAENEPL GRVLVQFEAE DPDGDQVWFY
SKQTLPSWLT LVPDTGELVL VDRSNLSNYN FTYAVTDGRL QTVGSVELHA TGVKYYRPIL
PTPLYRIDLL ENTTVGSTVL TIEGFFEKPN IQQPITYSLV GNFADKPAKF QLDAVSGALV
LAEPLLDRGE QQRRLLMMMV EARSYHLKTS AFVQVHVLGG DQQPPKFLKS NYEVSLLVNS
VIGTEIIQLV AVDMNEYETE EEKEEDDEDD NEEEEKEEVV ENEGEKENEL YRSPPRTVLS
YSIVSGNDRR LFHLDSSNGL LTVARTLPVE SAEHVLVIQV TKAGQRFLSD TASVTIRISL
ASEAYVRFEQ KSYHARLRVD ATVGSPILLV QAEGGGHITY HLDEHPIFAL HPLSGCLSVR
RPLINSNNSS VDVGEQFKLT ILASNLFGHS DTAQVTLTTV AAAAIDKLRN FGHVKFDQLR
PRFLSDKFVG HILENQPAGT VVTLRRPEGT NTSSSEVLRL SSLLQVNCDS CSFRLIEHWA
KRLFQLDPIT GTLTTVVPLD REQHHGAELL LFNVLVERID GSNVSVGSSS LAADTAMVEI
VVENVNDCGP VFEPKSQQVR LVLPVAEGVP VVRVRAVDPD GPSLSYRLME EAGQERSVLD
AFHLDSETGW LTVKNASLVL ARMKLNFLVT DGEFDDHAQV DLRTVEVQES VVQDDSIQCI
GSRLQAFENG NRSDYIGDVV VLKKRTKVDV IYSVLNDRTV GHLFTVHPRT GALYTTGVPL
DREVRAQWPV VVRASSLRDA GRVLAQCLVL VDVLDRNDNV PVFVGAPYEF RVSVDRTDIG
QLIGTVRAVD LDIGPNGRVN YSCLTFDPPF SLNSSTGDLL LQRQFTSADV GRRLKFRITA
TDAGQPSLST VADLIIVIAS SDMELELFSK SSFRLSIFEG EENFFNQALV VVADHPTPRA
GVVGYTMLNQ REDDPNQQFA LDFVTGELSL QKPLDREQID QYTIRLKAVD HERNVTDFAS
VTVVVLDIND NWPQFNQSTY SASLPEDSPI GCPVVQLHAT DLDQGDNALL TFRLITVQLL
GVDNSQRLEE EKEKSKFKIH SSTGLIQLTD ALDFERCSSY LLEVECRDSG TLSKASTVRV
LVSVLDVNDN APVFAPENTF TIYEDNFSVG QVIGQLSATD LDTVSRGKLR YGILYAAGQL
EQLLFTLNAH EQGILRVGPA MDQQFQVGNW LPEYRLQAFV NDGLFSSRTE FVVRQIKCSS
VSSSLVRCLP RFRRRFISIS VSENEPIGST VTSVAIADSS TTGHNHVHYV MLLGLGSGKF
MVNPDTGHLI IADQLDYEQR SRHQLVIGAR MDNWGIVSVL HVQVDIVDRN DHAPRFVASK
FSILVSASET VGTPLLRLFA RDRDQLDTAR IRYSLVNRGR QPRDLAASYF RLDPRSGVLS
VRRPLTALSG KNLRLTVKAT DGGSLEDETF VQVVIWSELL PSLSREPRAE SISLHVAEDA
PVGTRFGRVR FRAYAGAVAR MVPLTDETVA GWIGVEPNGT VYVAQSLDRE TRAEFSFYVA
LVDELQTDHS AWISMTLVNV IVDDVNDNAP IFEANSVQLS VPEDLAPGSA LLNLQADDPD
TAANGRVHYS LFQQADSEAQ SLQLFHIDSY SGLLTTTGPL DCETHATHRL VILAADGGRP
SLNSTLTVEI RLLDVNDQMP RFDRRQHWFN LTYADAVVGG TLIGTVVAVD LDAEPFNKLL
RYYIVDADHA DAWLLFKMVN GSLYLSDGFQ WKFVFSDNTD TERQVFKLTV EVTDGKYSDQ
TQVYVNFEQN DKNRKRCCHC GSDDDVIELA VEENMPVGSV IYNLPDNCTS TTTTTTTTTN
SGGSWMRLQG TKHFAVDSNA IVIAESIDRE LFVNRRHLFY LRSDEDLCPL CERMFVVNVI
DVNDNEPLFK RPVYERSVQE HENVTYPAFV VQVHAVDRDF GPAGRVRYRL QSDWDGLFRI
DENSGVLSVT EPLDREQQHE YSIVVLAEDC AQETGAKSLS AQCSVLLTVL DINDNAPEFT
ELVYKAEIAE NARLGDRVVT VKAFSRDVGL NGEIVYQLLP NNDGRRPSPL LAQSKIPFAI
DSQTGVVTVN DSIVACLSAG QRQIQLTVVA RDRGSPPLSN SSLLIVDLVE VNDHRPQFDR
PEYNVAIREN MAIGERVLQV SATDLDRGDN GLVAYRLFGP RDGNDASNQP LLPFAVMDDG
WILVNGSTDR ERMARWQFQV EAYDFGKPSR SALTTVTVDL VDVNEHPPTV VDCNTTTVHV
KRPLVSGMIL HMLTVDDFDQ SDQQSKFHFQ LLDHDDNDNI SSSSLFRIDP DRGILQLVAS
TLDHDHYVIQ VKISDNGEPI LSTICKFDIR LVDESKHRPT VEDFHCELWT HVGEFTGGII
GQLRPTDQDP LDKLTFALVQ HRGDDTFNVD SDDGRLLASA DLVSAGLYLL NVSINDGKYS
TFAKVTIDVH HISREMLNSA VTLQVVIAKD GQRFLQQSLK RLSRFLAKLV GVRVKYVHIF
SVQPSVGDDI GQQNNVVLSV RGGQMFDLLV AVQKSKQEFY KASLVSDRLV RKAGEMASVS
GMGRVKVVRA ACGRVDCQNG ARCRDVLLID DAGPVTLLTD DFSFVSPMHR QTAECLCPAG
FGGTYCDQKI DKCASNPCQA GMVCIADDTV TGYHCACPFD NDDLSNCHPS NCRSPPCTGK
LLFSFGGNGF VWFAMDSSFD YYMDVRMEVK TSIRFAVLLF SKGRNDFHQL EIKNGFLQYR
FDFGSGQAIV RNSVVLSDDH WHVVRLVKRD RQVSLTVDEK QNRLQLSGSS SVLNFFNRGS
HLYVGAEVTD AGNRSSVKNA FLGCIRGLEI NGEVKQVSNN AGVELFGNIQ LGACINGDVD
DDDDQDEDGN DRQYPPPHLM NNRQEVEEGK VHGACSIQPC LNGGSCVGRG SFGFTCLCPA
RYFGTYCEID RTPCLSSPCQ NGATCINLFN DFQCRCSKLF IGRTCSERKK SAEVEEDICA
SSPCANGGQC LLNDHVHLDS GDESRFSCNC TAGWTGPTCS LPSDSLLHAP NLIGGVSLME
FVGIVILLVL LALVASTVVV LCRRRRRRLH YRKVRVKRTR HEEILLDQRQ PLHPRRRSAR
ATAAAAVHGR DEPPPQPPPP IPPRFPRSFQ PHRGSKLSNF ESALSTGIPT VQVRPLSFME
RPAGDSPSAV RLLIHEQAAA SYGSAAEELE LLGDQATNKG MMGETKASSC FNTADDDWKT
ALDNIDSDSL DKLKRLAGIT TDESETDEND INVDVHSNTA SVARPTAKVH KSNKSSNANG
NSFHWDYSDW TNTIGNTGYP SLGHITDMNT DDDDDEANTL PRGICRLEED TDYEYAFHSG
SDDDNNETER VGIGLGNEIR EQIRAIGLLN DEINKVDQLK KEPPQSCIRR YLPMFTPPSS
GSERRRLIDS PQPRSTATTT TTTTMTTNTN FNTTVHDYSD VPLLSRDSEC ESVESIPLVH
LNSSANKFNS SLSSYFKDNK HVDKRLPKSV NNRSQSDVSQ VCELEDEEED NVVMTNAEKE
HEEEEASDSP PPASSSQGSM KKCDSTTAS
//
