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Database: UniProt
Entry: A0A0V1AFE5_9BILA
LinkDB: A0A0V1AFE5_9BILA
Original site: A0A0V1AFE5_9BILA 
ID   A0A0V1AFE5_9BILA        Unreviewed;      5148 AA.
AC   A0A0V1AFE5;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   25-OCT-2017, entry version 12.
DE   SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:KRY23541.1};
GN   Name=Rya-r44F {ECO:0000313|EMBL:KRY23541.1};
GN   ORFNames=T12_10237 {ECO:0000313|EMBL:KRY23541.1};
OS   Trichinella patagoniensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY23541.1, ECO:0000313|Proteomes:UP000054783};
RN   [1] {ECO:0000313|EMBL:KRY23541.1, ECO:0000313|Proteomes:UP000054783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS2496 {ECO:0000313|EMBL:KRY23541.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRY23541.1}.
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DR   EMBL; JYDQ01000003; KRY23541.1; -; Genomic_DNA.
DR   Proteomes; UP000054783; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
DR   PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054783};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KRY23541.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4497   4522       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4697   4716       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4757   4783       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4901   4923       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4946   4968       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5027   5046       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    235       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      228    300       Ricin B-type lectin.
FT                                {ECO:0000259|PROSITE:PS50231}.
FT   DOMAIN      251    305       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      311    372       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      377    435       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      615    850       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1078   1259       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4248   4283       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4286   4318       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4261   4272       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4296   4307       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5148 AA;  586856 MW;  6575CDF31752E698 CRC64;
     MTDFQENSTG EQDDISFLRT GDVVCLTCLA PCKESGTGSA ERVSLAAEGF GNRICYLENV
     SDKNKPPDNA TSMFYIDQAL SVRALQEMMS SESPNISGSS STHRTLLYGH AVQLKHALSG
     MYLTCLSTSS ASDKLAFDVG LCETNVGEFC WWTIHPASKQ RSEGEKVRFG DDVILVSVAT
     ERYLVCHVVK KQIIKFMFHI FSIAYVINKW KHSFSCVSSD VVEHHSKQLW RCSGAAHGAA
     WSATSHCLFA ICYVCGNDVL RLNHGNDECL TIPENWSDSH QNNIVIYENG KSCNQARSLW
     RPELIHGKWQ SSLIGWEQAF RIRHITSGRF LALNEDNQVC LLHKDRASFE STAFIMISSK
     DVKRSTFEEK EEEGMGVATV KYGETVIFLQ HLQSNLWLSC QTTAVTKKNM GKVEEKKAIA
     VEEARMDDCF ILFKAQEEES QSARVIRKCS QILNRFLRGL EGLQMEGKDS LAWNRADLSE
     TVKLMEDLIQ YFAQPEESVD FESMQNGLRA LRNRQDLFQE EGLLNMIIDT IDQFSAVESM
     TELLDVTKED KCKNWQDIST YLYLLVAAMI KGNHSNCTQF ASAQRLNWLF SRLSNPQSAE
     GILDVLYCIL TESPEALNMI NEDHVKAVIS LLEKVGHDPK VLNVLSALCE GNGVAVRNSQ
     NVICSELLCN KKFLLQTKMI DQVSSVMANI FVGSYENSAM YPRWYFEAEL EYMESMRTGG
     QKPHLRIGWA SSAGYRAYPG SGKKWGCNGV GDDMFSFGFD GQYIYAGIAS LKLSKLIGGI
     EKFVGTHEIR KGDVIGCSID LAIPEIQFSL NGHQIGTSVR NFSSCDCLFY PVMSLSAIVS
     CRFFFGGSQG KLRFGPKKGY LPISEAAITP VKLISCISFG DTRKGYFAGP STVISDYIVF
     QPKPIDTKDV SLPKHLEDVH EKLAENIHEV WAMDKIEKGW IYGERRSETQ KTHPCLTSYE
     RLPTAERSYN LNLAKETLKT IVALGYRIDI GKASNRVKTF RLGQNFLMSN GYKPAPLDTR
     EYELNETLET LVDLLAKNMH NIWAQSKIQR GWTYSKNENV NIKTTSHLVA YDFLDPNIKA
     ANRDKAGQII RSLLVYNYCI EPPTAEQDEG AVKQSQVMNL QKRTYRFEKR YAVKSGKWYF
     EFEVRTSGFM NVGWMDVSAS PDGDFGLHKS SYAYDGYLGR KWHGESESYG KKWNVGDVVG
     CFLDLTDRTI CFSLNGELLL DSSGTEVAFD NVSAEDGFVP AFSLAPGQIG RLNCGQNVNT
     LKYYTTCGLQ EGYEPFCIRM SRQAPMWIAK CEAEFDEINE EEKRFKVTRI PQSGDNPPCL
     KLQCKSAGML ERCSLALFRL NLPVFCKEAN DNRVCNQYFT ETLSERNAGK RNCESDRIAE
     SSRRGKMKGI RGSRNQDENI SFHDQQNYAD QYEVSNHAVM KSNYLVQKTF SLDDDSSEVT
     ENRFRKAPRL RSSASEANLK EKESIDSQDK ISASYAVSNT KRNLRPFKVL QSFGQRMRDV
     SVGRSRKQNA RKLQEACASK SKIRSDENDK FSSGHLNSRK LDDRVADVDS TESLDMPKSG
     PGRRPTVIRL ESDSKVKKRS NYFSSGHDLL VEASKLSAPS GNQHVSIGAS VSFYSTPDDY
     YFGVRVFPGQ DLANIWIGWL TPQFSFTGSQ IAADSQRICF LESTHSTLDN IQEFRSCYIV
     NGMELLTAAG GSSSVSKMAG ILAGCLINTA TGELKFHVNG KQTEMSYRVE PGTILYPAVF
     VLPTSREVLQ FELGNIEKTL PIASAQLNER SNAVQLMCPP RLKMEICKTR TWLRVPDQCA
     RVTSLKLSDT RGWSVLCDDL VRTMMLYVPE RDSSIDILEL AEHESLCTFH QQTLRLYCSL
     CAQGNFKIAH ILCQHVDEDQ LMYAIQSKYL SGSLRQCFYD VLIAIHLKCH YDARLAESHE
     YIIPLNAKLK DRNYFNYETK SVYPHALNSD ITLKSSINVM EVKKKISTED EKFLMGPTFD
     FHTLKQYVVD ALEEATLEAL MNSRDLIGGT NTTHFLPILK LFDTLLLVGV LSDTDIHRFF
     RLLNPKSFQE TLDSPQNVKG LVDLDLDEMV QLELCHIMNH LCDLQLQGRV ESLINFAETF
     VGETQNACAL DEIFEKGNLC FNYLRDQLRR YLEIKQTDMP SAEAARKTKE FRCPPKEQML
     KLLDFKADRD EQTDEEGELE VSAMSEFLQR VLREFHCNMV KFIGNSDKND DNYSANVEQK
     QLESENMNWV EKLAWMVVPV PPALLSEDER IKFDGEEAFR NIILSTLIKW TGNKAIDDPN
     LIREIFGLLL RQYTRISEVK SALKTAYCIH ERSIEDVQSF LDNLCQIRRL LCVQFEATEE
     EVLKNSLWDM MNNKVFFQHP DLMRLLKVHE NVMTIMVNVL SRAQKSELDD RRNRSTQDDM
     KKAFQNSISD LVVACCKFLC FICRSSTKNQ AAMFEHLPFL LDNATMLLAK PSLRGSVPLD
     VAYYSFMENS ELALALKEDD LEKVAFYLSR CGLQANAEMV FKGYPDIGWD PVEGERYVDF
     LRFCVWVNGE CVEENANLVI RLLIRRPECL GPALKGQGEG LFRAFKDAIS LSSEISNLHK
     GRDLRSRFNF DLSHYPNPEI EEEDYIDLGA AILGFYSSLA DLLGKCAPDH LTVNSGKGES
     VRLRSILRSL TSVEDLEAIL ALRFLLPNVF AAKEESSRSS SIGLLPCHKQ SILLFLERVY
     GLIDKEMVFR LLEQSFILDF RAATILDHPA YAESDLALAL NRYLCGSVLP LLTSHAHCFA
     DAEHYYSLLE ATLHTVYRMS KIKSLTKSQR SAITEFLLAF TKEIHPGMMK KLLQKVVVDI
     SSLNEFATVP LQIMTQHYEC FSKHYGISMH EDTASEEQKR LSMLLFTTIF DSLGKRAFDS
     DLFASALPCL TAIGSALSPD YAMQSYAEEE IQNMNVPSGH MEVWRPHPVD ASNVQLSVNL
     QNLVQRFAQH FHDSWASRKL EKGWRNDDIY SRTNCTHPRL KPFGMLKEFE QNFYKERCSE
     CLKALLAWGY SIEQETQVSS VQPKSMNPTS NVRSASVFCP QPIDLSNMTL SEEMRELAER
     IAENSHLIWV SKTIEDLNDA NTGIMVLLVP WDILADSEKR KHRFRAQEVL KFLQYQGFRL
     KSPLHRAREE YEQTVVDSNT HRPVEKRFAC NLLEKLLAYL ENAAQKMEVI KPSKQFSRYR
     NYTLPSEDVK FFGKVLLPLL ESYFRSHRNY FTAASSASLS GVASIKEKEM VAGLFHRLMS
     VFRSKHNAFG CHVKSTVRCL QVLLQAIDFR SLVKINSDTL RTCAQIFLSN MVSDLMNITK
     EIKNNGRYAE IKGKTLPCTS SLLFLYEAML PLLTTLFCHL SKHGHGQDFL VNDIQVGCYK
     IADCLYMLAS PITISRKSVK EEMEKHRSSI GQCLSAFACC FPVAFLEGDF NPNSRGSTVD
     RQHLLSESKD TSSSLLLNIP SLDNLLSNIE QLSNTNGKYQ DAPAIFDVDI PMLCSYMSFW
     WQHGPTNNTQ EKNLSAVSSD HINRLFSACS RLICDHIGIA HADWICHLAP FITPMINYVT
     IEPVRDYLLP MAEKVRMQAD LAFKEEEKHR MHPDVFDEST VIELHSILIR DVYALYPILI
     KFTDLHRARW LKNPCWETNA LFEHVAFVFK LWSTSQHMKR EELNFITQFE SDFMTGTSRK
     TGKAAVAFRK KKRREGKRRE KDSGSIVVAC LKRLLPVGLS VFGGRELDLL QKVKEKYMKK
     ENDEKIKEYI SSSLAVPDQE DVFDKSHWQR KLYQQIGKAQ MLGIDSMSQE MVLDKIIFMG
     VTLCNLHNVE HPQTFQADAW RKIVSSQRKR AVVACFRMVA LYSIPKHRCV NLFLSAYIEK
     WLKSEKVDED LLISEVTVAS EGRMQRLRED VEEVDEQCPP DPLSQLVQCF QRAATSERKQ
     LVPIVDDNLY IQYVRVMASS IHINDDEQNN AEDDAISMEA QELEKQQLLH EQSRLADRGV
     AVMVLMYLSA CNGEPNVMVE KTLALGIHIL NGGNSDVQNR MLNYLQEKKD VRFFSSISGL
     MNRCSVLNLE IFERQLKAEG LGMGAELSVG KHQNLNDSEF ICSLFRFIQL TCEGHNSEFQ
     NYLRNQPGNT TSINLIICTV DYLLRLQESI MDFYWHFSSK EVVDEAGKAH FLKALSVCSQ
     VFNTLTESIQ GPCVGNQMAL ANSRLWDAIN GFFFLFAHMM DKLSKNHTQL ELLREFLSLQ
     KDMIVLMLSM LEGNILNGSI GKQMVDTLAE SQQNVQLILK FFDMFLKLKD LTTSQAFQEF
     DTNKDGWISP KEFLRAMEAQ KMYSTEEINY LMMCTDVNND GKIDYMEFTE RFHNPAKDIG
     FNLAILLTNL KEHITGDSRL DQILQTASSM CEYFDPYLGR IEIMGSNKRV EKVYFEIKEE
     WLEQFNKPQI KQSKKDFLFN VLQDDGGEQG KLEAFVNFCE DTIFEMSHAA EISSEDRDSR
     IERAKKQREI FTGMADKTDT ISAFDIILKI MKKMGTSIVS FCRYLRPSEL RQLKHSAALH
     FSSMTYGQLI LIFLKIVLFI FVTIFRGAFY LINTFFRFIL LMMYGVWEEE KASSKLTAEN
     AVHHTLPKDF NIVPQLYEPE KPEVYEAFGI QLTQGIGEGL SMKNPNNQPQ FEKSFSMHIG
     NSSPFSIASA ESASVQNERQ LMIYSNQIPE TYTPAAVSVC NDDSNIVVKE IYEPKIAETT
     SSAKGSAFNF LARNFYLLKY ITLALAFCIN AILLFYRVAD NPSNDEKVVL EADNSKLQNE
     EHMENGIEEE LAIHDNYYYL AHMLIFLSVA HCAASLALLI AYYQLKVPLI IFKREKLVAR
     KLEFEGMWIT EMPSEDAVSG KWDSMIISSP SFPEKYWDKF VKKKVKDKYK DQFDEEELNR
     LLGLDKTVVD GSNSSSSSGV DWCYQIWKLG VIFTDGSFQY LLMYLFFSAV GIWNPFFYAG
     HLIDVVISFP MLQTILKSVT HNGKQLILTV MMVLVVVYLY TVLAFNFFRK FYVQEDDGEE
     TDSKCNNMIS CFVFNVYAGI RAGGGIGDEL QSPYGDEREA WRILFDMTFH FFIIIILLAI
     MQGLIIDAFG DLRDQQESAQ DKLESNCFIC DIGKDFFERL PHGFDHHTTK EHNLAYYLFF
     LMHLINKDDT EYTGQETYVW ELYEKRCWDF FPVGECFLKQ YEEQLMAS
//
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