ID A0A0V1CGH6_TRIBR Unreviewed; 3283 AA.
AC A0A0V1CGH6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=Smg1 {ECO:0000313|EMBL:KRY48092.1};
GN ORFNames=T03_10790 {ECO:0000313|EMBL:KRY48092.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY48092.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY48092.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY48092.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY48092.1}.
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DR EMBL; JYDI01000219; KRY48092.1; -; Genomic_DNA.
DR STRING; 45882.A0A0V1CGH6; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR031559; SMG1.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRY48092.1};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1891..2217
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3251..3283
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1337..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2910..2940
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1350..1366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3283 AA; 374857 MW; 0021F69DF0AD787E CRC64;
MVDYQSSIFY TVSMLRNLLF IMYSDSSSLW LSNADSMTEA VDLSTLWSKI RTILYATDGD
VKELVQACEQ FKTLFESQAN SDGHVQTSIS IIDVAVGFEK FFTVSRFNEE FLRCIQSLLL
PLTMNAAEGE IVKLFKYLVD RIYDLRFECK QAMLLKIVSE LMTTSRVILC FADSLYLLAS
LFKMQCMGFY YPNTLELFLE IFLRCFGLLI PIVGMPDDFF QILLRLLVVL QPRADKKKQS
DRLIRVGRKV LHLYFPEDFQ RGTNILLALI KVAQDDAERF KNGLNFNEHC KYSRRIWRSV
SLFNSMISIF STEERQWNQH REFLQFLNTM VPMLTSIAVL MLHSSAIVNL ATRSIAQLHE
LLPAGDKCIF LKSIVELGFL FLDPNLTLLY LDIESILELI KQIIVHKDRC LSAVHVSALI
GPYGILPKLR FHQEATIVRL TMEIYRSLLL LKGDLCSIMS YRQHKITSVS IFNRMIVGEL
VVSLEMLACR GEVEGLDQQP LKIEFDNIWN SQLESDVQLS ELKFILHFNA SLLMLVCRSE
AFRWISIANV PDIYSVLTGN SLLSSKWLTA FFPSVHYALL MLLRIYCTSY RHFSSDEILC
MLRKQGTYNF HDYVEMIKQL LMNDGISVAV RKLLYEWINC IFSVVIKDDD FKSAYSADLV
ELAWAAVTFH CDIIKCKDEF LCMLVQIFYS QFSYPKIVRE KLYATILLAS CYSCDECVSR
GLQDILPEFS YDDPDERAIM LKMANNAQLS SNDQQPVSSH LFATLMDFVL LNIDASELTI
FHLKYFTDTA KFMIQYCSTR TEVEVLINEY PGSVWMMALT MLANCCIENR LKTIYGPKSS
SILHLVEIAL GSVTRVASSS DRTQLADQLS AERLHSVQCN FLLYFVEILY KMMYRCYTNI
DPQAHVGLGS FYRINWNSFD AYFRKIRPSI VGLASRQGEY ETVLMWISRL SSSDPILDET
PPWGIYSFLL NVVDAYVMLQ AAPSVIGFSH WIENKLKIDD QLIKICSHKA SEQYEITASM
LTDWVMSVES GNNSNPDVVD VLSIQIKYCY EEIVDCFVKL GDWSMAATWL KRGKQSCGVP
VYKWQPLVDY IERMANLAAN LEKREAKIDG GDGDADQQQL VKKRPTDYRN FLCYVDCTFL
NIMENNEFGS DGMEEKLHIL LQDLETRRFL CSTYMKPLSL CKDYEIRLDI IKVLENACRW
KNWILGPVDT SQLRIDQLTV MYSIFCMTNV LPCGREVCLS DFCTSFAKRA RKTGNLNLCM
RIWRRHFGCN STAELCSFLL VLIARYSQAL DCAVEVAKLL WEQGRGAGCD QRVDSALKFL
TQAVAVAVWA NIPSTDGSTK STPTTADVND VDDDRDDDDD YDDDDDNIPL AKGLVVLASW
LGDVQFGKRH LPPPNNDDAE IAFQALFQSK LQQLQTEFDL NDNIADGVAL SLAVQFCRTS
VKAHHHYVGW LNSIIFSLVE EKEGFHAFRL SSKEKQFITS LLSAKSKVNL DNVLLLLETV
RSEQNQLTWN VICPDVRKVC TSSFALEKLH EWWEARHGHL FNLYNTLCES YFVILRNNYP
DDFITVDATI QIIRLVTSHY TDLKDCLHDG FSSVDVGCWK PVIPQLFAHL GHRNAGVRTL
FADVLCSMAV EFPAMVIYPA LAGLSGDGKH YRPADFYAEE MDSKLNSSAD VSYNESEAEE
EEEEENDYRN ELIESQFRQN CCKRILDCLS ELYPQMVRDT TEFVAELKRI ILLHDEVWYS
LLTSMRPEVA RRLRDFYQNQ EQQLPISDER KEQLKRGKTL LMKKMLFQIL VDLHEVTSKL
PQTKSEKIFS ETFSPRIGKI VEQVEDENCI DLNKIWDEFC QLHADLAEQT KNKSWLLKME
EISPKLAEMK DTMIPIPGVF ENDQPVMIKS VCAEVKILPT KTKPKKFSFV GSNGVKYRYL
LKGAEDLHLD ERVSQFLNFS NILFQSSKKS LGEAVYHARS YAVTPLGQRA GLIQWVDNFV
PLFLLYRKWQ LRQGGKNVTR PSELFYEKLR TLLSNEGLPA KHMRNRSKCP LPILRKVLDR
LIEETPRTIL SDAFWIKHVT SESWWKAQVN FARSMAVVAI IGYVIGLGDR HLDNLLVNLE
TGEVVNIDYN VCFEKGKLLR VPETVPFRLT QNIVNALGIS GVEGEFRISC ENVLRLFREH
KNTFVTLLET FVHDPLIDWR KTYGIGPNGL VVHSILSTIQ GDMKLRKYVE QSRDWNKRFF
LYRYEECKAL WIENRNSFNE TFKTSSEMLD QMEIICNSIA NTRQRCATYE AVLKLISQAT
ENPDHSLYKF LENNQDFTGV YEGVIASYAE LMSKLKKNQE LNVTYSNSIS QLNNLHGFRQ
KVDDAFSKPP QCFIELAVEF LRATGQTQKI QPYKNLESKI VPSFSALREL CNNLLDLVEA
YRSAQLLVPA VDRKKHRLHV WLELLESVSK CSCDSGGGGG GGLEANVQQT ERLLEQIGQQ
QQRGGRTSPE QFYANACRTV RMFQSVLDNG EKMPTIRAGD LKKIFANTAD MGPVFIASSE
TALVNWLASI ANEMSRLEEG NCCTKADDQG SSAEQQARGM VSFGWMDIYL TVLKYLQSVR
QLLVLPAFEK FSNQSILQRL DAGQRLFQCC VSLVEQISTF LVPTMYRVTV DNHAELSSWL
MGVVDACATA STLSMDKAWQ TLADEQLPVG MEWLEADNFD SHHLLDQLQR INDELRVRKP
IFSHRVGDEA MTVFRHCLDS FMAIKDHLKL LLDCLPQGGG RGGSLPLPTV DYRWSIVLDF
IYNYTMYRCA SVAVSYAEGD QSASVSAVFV DLPDAVGTML WKKLLLNSLP SALLNNVVDS
VNNFRLSTPN DVPVSDAHPM VQQYQTDIRN FVQTVQIELT KDACEVLKNA LVPLNGLVRS
YAWHHEIVLK RAVDPLSSPS VVEPTCSTVL IGLNEHLDQL RNIVNELKES REELSTAAKD
TISRLTWAAG ANATWSSKLE EFERAKESDL GQFNIAVELC DRFILIADSL YNYESLKLDS
EQLVKLDNAM VENVKLYLKQ LKRYMSIAAG MDPAEIELAK LKPSQEEHVT EKWLLSILAD
FEKRHSEANQ ALTKVQDEFF AKKTNFHAIT ESVRLLLNEH RKFTAEARAY MKHLAFSGDE
IEAKLANFFL HLQKLHTLAF SDVLRTDITS LPDTWDFEAT KVAFKRAAYL TNTIFDVLID
FVDPEAASSH SKARVCRLNY LILKFTVGNQ SKSPNLILDV KSRSGKLNAL ALNAWKCVRA
KLEGRNSNSE IPLSIADQVD ALISDATNLD NLALMYEGWT AWV
//
