ID A0A0V1CHA6_TRIBR Unreviewed; 2188 AA.
AC A0A0V1CHA6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Plexin-A4 {ECO:0000313|EMBL:KRY48615.1};
GN Name=PLXNA4 {ECO:0000313|EMBL:KRY48615.1};
GN ORFNames=T03_3458 {ECO:0000313|EMBL:KRY48615.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY48615.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY48615.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY48615.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY48615.1}.
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DR EMBL; JYDI01000201; KRY48615.1; -; Genomic_DNA.
DR STRING; 45882.A0A0V1CHA6; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd11236; Sema_plexin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1346..1367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1549..1567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..523
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1243..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2087..2109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1371..1398
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1252..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2188 AA; 243235 MW; 2E1660E943584798 CRC64;
MGQIVALIIS ILELDRRQQF PNQLNRDRRE CLSAWHGADG GGFVGTGPVG RRSLLWAMHR
QFIKFFTIPQ TVHFNGCSLH SGHWLHVVER LYTGRVYVAG VNRLYQLNSN LLLQSQVETG
PARDGTICTD DPACDPRTRL SDNYNKALAI YHKQTKLIVC SSLYDGHCRL RNLYNISVVD
DRVVDQNVVS GDLTASAVLF VNKGPNDEDV LYVGRTGKHG NSDRLTAVKT LSLNPDQLFN
SVYKGVSSES SLVYYTDLEM HRVDYIYGFG SGNFSYFVTK QPKLPGGRTP YISKLVRLCN
RDPHYYSYTE VPLECIDDNN GGVDYNLVQS AYLGKAGFDL ARDLNINTED DVLYVIFVRG
VNEPVRAQMT RQSALCVYSM KAVEQRFLDN VQLCAQGVSM CGLAHQQRPC ISTHYSMSAL
LCNNEVNHPL DGSLPVRQKP AFTTDDSRLT AVASTTTHMY TVLFLGTEDG QLKKVVVETA
TSAYQYDTFR VESGWPILPS IDFDMSNQFL YVLTNRSLSK VRVHECIRHE RCQQCLNARD
PYCGWGSLEN KCSTQEDCKS SHWLPYKDSK CTSLTKVVPD KIQITTAKFL ELTVQNFPAV
SGQLSCVFTI GTKKLITGAS GPIDQAISCP TPQTNLLPPI PRDQHELKAL LSIQVDDGPD
FAAINFTFYD CSNYRSCHDC VNSDFGCDWC AESAQCTASA AEQCRGQLLV NGMMSKTTTG
RRRGAALFCP HIVAQDQRTI LVPSGTVTAV TVRAVNLLDF QKEFTCEFSI GNAVHRRPAS
RLGDVIQCDQ MEFSYFDPEP NVTAGFSVTW APGKALDNVH NIGVVMYKCE RLASNCGLCL
HLPASYGCGW CTGGQQQSCT INSKCDVGGS GSQRRWLHHR DTCPNPTIVK FWPTAGPVDG
GTRLTIEGVN LGRDYSEIEN AVRIKNVVCT PIAELYEPST RIVCVTGPAK HRKTQSGPVV
VKIRDVMDYV AVSDQDFRYV VAEIGGFTPT SGPQSGGTVL TIRGNHLNAG SRITATVGGV
PCHVLSLEPR RALCRTGASS LAGRTGGVEM RFDNAVATYA SQQFTFEEDP AVLVVSPQRS
IVSGGVEVDV RGERFHLVQR MTMHFTLQDR QTSRSECTIL TADQALCRTP ALGPLIDQHL
YPQPDRPLLV DYGFSMDGVD SANNLSSKSG FRPFSVYPDP EFELFQSSTG GTTGTTLPVK
YFKNDYLTIN GNNIDLAVNE RDVRIYVGAE LCNLTALASR AVTCKPPDKQ PPSALGQQQQ
QQQQQFHRPA STVVGNQQLS SLEIHRGSTS STSTSMLANQ RAAVVATLPE VVVSVGGRNY
TIGYLSYDDP SSSETALFGS WPAKTVATVA AVLALFVGVV LVLLLLYRRK STKQRRQMRS
LKEQIDAIEL KVANECKEAF AELQTDIATE WTADTTTKAG IPFLPYKDYV LQVLFPNSTG
QASSFLRLEP DLAPRSDRRS RGAVEKGLLQ FNQLLMNKTF LLTLVRVLES NKYFLSKDRV
YVGSLLMVIL HERMDYCTDI LKTLLAALIE RTVRSRHQPK ILFRRSESVA ERMLAAWFTF
LMHKYLLDCA GQPLFTLYWA IKQQVEKGPQ DATTFDARYS LSEEKLIRQT VDFHPLVVYV
SNGFDSSPAS SSSSAAAAAM VAATAVTAMG SSEVAVRVLD CDTITQVKEK CLDAIYRTTP
YSRRPSALEL DLEWRTGVSG RLVLQDLDVT TKPEPGGWKR LNTLAHYKVP NNASLALVAK
QSSMYNLSLL SERSDKSSTF SLKNSPTLAR AFSPGKESSS DSGYKIYHLV KPHDHYYHHH
HHHQADIGGV ERVGGKMVSE IYLTRLLTTK GTLQKFVEDL FEAIFSTAHR GNTLPLCIKY
MYDFMDDQAA QHGILDPEVV HTWKSNSLPL RFWVNLIKNP HFVFDIPRPA KIEGCLSVVA
QTLMDSCSTQ DPQLTKDSPS SKLLFARDIH SYREWVERYY MDVRDLPVIS DQDMNAFLVE
ESRQQLTEFN VLGALQELYK YVNQYKDQLL AALEEDEFSR RNRLPAKFVQ MQRIFDGEEQ
HHSMQQQQQQ STTALAAGSN MINTSNSNPY PANPYIVSPS TLKVINPSSA SASSSNQHAG
DNNVNNSTSN NSSQAQYFFI RFIFLKNTGI SSSSSSSCFA QKNIVANFEL NLITTATSYS
HWRSIFYCVV LLKKSSNLCL PLFGDFDV
//
