ID A0A0V1CLW4_TRIBR Unreviewed; 786 AA.
AC A0A0V1CLW4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=Ddx54 {ECO:0000313|EMBL:KRY50293.1};
GN ORFNames=T03_17070 {ECO:0000313|EMBL:KRY50293.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY50293.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY50293.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY50293.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX54/DBP10
CC subfamily. {ECO:0000256|ARBA:ARBA00010379}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY50293.1}.
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DR EMBL; JYDI01000153; KRY50293.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1CLW4; -.
DR STRING; 45882.A0A0V1CLW4; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0043186; C:P granule; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17959; DEADc_DDX54; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR012541; DBP10_C.
DR InterPro; IPR033517; DDX54/DBP10_DEAD-box_helicase.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF8; RNA HELICASE; 1.
DR Pfam; PF08147; DBP10CT; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM01123; DBP10CT; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000492};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 26..54
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 57..230
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 254..409
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 590..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 26..54
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 745..773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 89767 MW; 3FF922E38B304B4C CRC64;
MESADEVEID YAKLLIAQNR KNKSAGGFQA MGLDHNVFKG IMKRGYKIPT PIQRKTIPII
LNGKDVVAMA RTGSGKTAAF LIPMFVKLKI RDPSAGVRAM IISPTRELAL QTFKFLKEVL
GKFTGLRASV IIGGDSMEDQ FAAIHENPDV VIATPGRLLH LIVEMNLSLK SVNYVVFDEA
DRLFEMGFEE QLREVLKRLP PDRQTLLFSA TLPKSLVDFT RAGLRHPTLI RLDVDSKLSD
KLKLTHLFCR REDKLGILLS ILGDRSLVEE NSLTLIFCAT KHYVEFLHAI LEYFKFKCAC
LYSSMDSEAR RVNVEKFHRK EINILIVTDL AARGVDIPLL DNVINFHFPA KAKLFVHRVG
RAARAGRHGH AISFISTDEY AYLLDLYLFL GRSLQFSTSG TCADVGDLIG TVPQRRVDDE
NRTIALLLNT TSLDLESLQK VAENSYKHYT RSRPTSSAES VRRAKAETRL NNLPNHPAMA
AVGFGCEKLE QEKDILLANI KCFRPQTTVF ELNAKSSDLQ WQVMKAKRRV HQKKIDQSKA
ATVAEMNAAS NEEDHPLQQH VDAHANDPVD FTGVFSEKIE SKFSERATES VLSHKKKKKK
TQNQKMTVKE EEKKEQFFIP YVPSDLHSEQ GLSVENNFTS ELGSAVIDFM DDEMEKMQRR
NQKTKWDRKR KKFVNACDED NKKRSSKKIK TESGVWIPAS YKTDLYDSWK KKLRMKAVQG
DVDQQENTEK RLKFFRRNRH AKGRKGPVKS ELKSKMQIIK QRVESEHRRK RNAKQLTNEK
KQKKKK
//
