ID A0A0V1CMH7_TRIBR Unreviewed; 3752 AA.
AC A0A0V1CMH7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=prkdc {ECO:0000313|EMBL:KRY50517.1};
GN ORFNames=T03_14873 {ECO:0000313|EMBL:KRY50517.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY50517.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY50517.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY50517.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY50517.1}.
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DR EMBL; JYDI01000148; KRY50517.1; -; Genomic_DNA.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 2.
DR Pfam; PF19704; DNAPKcs_CC5; 2.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRY50517.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2529..3153
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3332..3666
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3720..3752
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 3752 AA; 430453 MW; A10244127EF5BAFF CRC64;
MAYSTVDQIR DALNSLKDFI EGADSDQAED CVQQIFEHFR KLSGSERNFG FCFNSLLSND
SNSLLSILSS SIGKTAFAQT IGYGIDIIRL AIAKTTSLSP SHRKAIMRFT LRLLKQDYLK
GRRENVLYLV NECIKYSSVL STEGGELNFC YDELLHCCLA LIDSLKKLQS GVKKGLFIII
GTLCQEIPEK LITADHNYAL LFANIMSEEL KNQMCSSIHS PSYSVIEGCF LGLNDLLAHF
SNLFDGACRM SCSELFCLIK KACNPKNDVH RLGHLKAALG LVISHVQFFR HHFLDEYSLL
NEYFSHWAKH SDREIKTYSL NAEDLLIREL ATELITKVDS DPNHVRSVYK YFCNQFDEVF
SNTSGIREIS MISKSYGRLF QIGKALYGEE EVCKILRKLL QRFEYLSTTS SDAQQQKVYH
ITNILETASR GLICLSKIAD DVWQLMERFH VTLFHNFPLM EKRFYHRCKV INFATFAAAY
GHNYQYIQSI VFQSLIRVIA SLPSVGKESI VLPKDENAFY LADYLPFWKM LLDSEFVDLS
EFGFDRSMQV NIRRTFFDCF MKSFLEIVRL LSFETKAFQD VEEYTFRFSN PILHVIPTKQ
ADYDLFYNLV ELCRSVIMKG SHVLFEPWLQ PMLTMLLELS SRYPMVSGFY KLLALWVTMA
EKLNYFNSTK QDDKTENCSS HYKLLLSDFI DHVLVESCRF QGELLVSCLR FLLALPTCIV
VEKLESIKES IKSSLKLGLN YLPIACVCLD ALEKWSAEFP EDEPQLDSFY TDLLPIFDDY
LRCTSVDETL VSNNGFNYNG EKSTLFNRKR NSGNVFDKSD DNDSEEEIPN PQTVLRRIAS
FVGSLGCYMN RFLINSADAG SLLRWGHGSH LEFICPFPDM KFEIALDTLL PRLCDLALSA
GDRPLKVAAC EALHACVLFL LGNESFRTVK VRDRESISKA YSHIFPVLLK LACDVDEVPK
QMFSTLFVQI LHLFSGTDFA DKMVTSCLLD TLMDGLCCFW NSSLRDQSAY YISEYCRWSM
RRVDNTGQNM HSESKVELLV QTIITFAVHS SAVKRAGAAV AFNNLYKIIR EKRWLVDIYI
LEMFFTFMKS LYLAENDDEL YGTVDECKQA IKHIRRIILY NLNMLRIHNE RRRTPNEWSQ
STIHCCCDWL LNTMTWSNYQ FRSECFVSYQ ELTNAGLEIE KLHFLRHIGT SIFGLIDHFE
RSHRSVLGSF SICNLQDRVA TGTSIYALVL WLETYEAMID GYVWALNTNR ISMEDWNNYL
LNEHPRMKSL LFPCSMDLVN SIVIGRNFPN ISKTQRNRLN KTRCKCFVAL CKLISALVNC
PNLNNFQGFL KLLLYPNTWN AFLKVACDPK SLGFRLYSKQ LFECISQDVR LLFLALKNNT
FLVQQVSTNM KEYLTQYNVF FPHCSLIINI IMVLFIRFYP WPDVESVVTC DSHLAIEQQQ
LLNVYGMLVE VGLRCVVELP GAEFLWTTVA DVYFSKRIGL PPSKLGMVKQ IFRVAALTGS
AVDVLIKLLM NTESVRLAEC STLCSTKGEL LIANFGEEIA LLLCTNAELF LKHLKEASRC
QPDVVGRALL HTVTVVVHSS DLRKKYGRKL ALQVLRIFGQ ELLHWADVAV SNETLKLLWL
KLIMKLILID SKITEWQEFA PMASAYFMML NDQSLTLDFK NNMLSLLAGF CTFDKHASEL
GKSLKLFMVN NFPLKSDEFA KGTAKYDQYV AACQKILFAF GCTGSPLILE LLLNMICREQ
SHPIASDLKH QLQKFSSRTS RAVLENILVL LDEMFFNPSS CVCSSLRLAL LNEFFIPFLH
SLKSDLLLSW TCRRIQTLVS CLTESSISEI KTDYEEQIIT RIGCYKIFEI IYKVLDLEFL
KTEVNSSYLG SDSQMKNELI KKLASCAVGA KKEFCRDSKL GSVQRHFFEY RCAAQNCIIA
LCWESIIDNE VKYEFDREIQ EEEQSAGKMY YSREEKPPSA ESENQVELSV LLDSSLSVMA
TQFDLTESLE ASIHCAEKET ESANDKDVFR PFYLEWISPI IKLIVMDEFG SNILHYFRVD
LIVVLFEWTA HVKKHCCSKS GKVFKRNLRI IETMLVLWKP WILEKICFPL HDEMENLCGI
SILCLCLNTV PETFSFLTDP NHESGFFNDL LDWFPSVQGD LKTACLEGFL AVSKYKGDLF
EELKSRGFLK IFSLRHERDQ MLGMYIVKNI HANLSVENIS DLVSSFSSVV VGNFSSSCRR
AFAEMCCSLY TKLSSLNDSS ENSKTALATT KMHLLTMLSD SNKSIRQLVY NFWCDASRLE
ISTSARLLNC LSQLYTCATE STFLSHASYV MLELTCHSPD YTRLIYDHPL EDCTFENLPI
STHWQSRYAS LEVPADNLTV ILDKILQDIK KPKSSSVKKV DDLDGDLQFL KNRILKDTEE
KAFFVNLDRK RQKVIERLKQ QSLDLRGKYR SGDFPDIQIP YSAVIITLQA VAELDKVFAG
QLFESLMYGV VAHVIECYSF EVTEKYFKSI NDGVREIFRS MVTFHRPLVS CLMNFLYNFI
EYVDFEPTDI ANVAIGSGQP DCGIVLLERR IEVAFEDTTA STSHEWRPKH VNEIDQLWVE
LSRLYKQCGE LENLRAVFTK HLLTAEETKL ALEMEAAGDF EGAAAIYGET FNNKKRKSGG
IVEKAEANLL YEARIRCLEM LNDWKGLEAW STTFGSTGQS TKLDQIWETD YLINMHLPVF
LRSKLKIALT SDSVALEELS TFVEQNQSVP KNREILENRH SGLLVLLNIL RENFTKSQYF
LSLSMDSFLK CYPTLRVCDV TARLKLVQDL LPVSETAKFL HLLHASDEFK LENVVKLCRF
WLRYGLDVET TLTTTADDVV LNRKTFLEIF GKRLVDSGIS VSNVQQSLLP FRLQFGYQYL
KCAVRQNNHG VLLQRLQDKH LLLEASNYET WALLQLANCA NAVKSRTAYL MQALKLFDLK
KITDPELNTT ESSSADQFAL IGMLFDNVAE TVVASSENTL AEFCLSRLFS NTDTAADISE
LVTLCYDQAF RYLKLSCQYS SVQSNIESPK LTEPLMELSS FCDRILRKNG HTSLVNSECA
CVMVRSILMS MKNGSHLARQ LFPRLLSVME KYPESELEFQ AEIDSVPSWM FLSWLNQMLS
ALKRSNKFYS ILERIADDYP QALIYPLLML KSATGDAGET DFYRLQLKLR KTKIVKDFID
ALTLLSHPDM HVIDELESII MNVSNKSNEA RRETMVKLYS FVTFADIRKE FLGSFWKCHF
QKFLPKIQEI FCVDICTFDS KAAENYLRLC SSILNELRTF YIPECCPNNL NEYSPWLTAY
RPHPLDVFLE IPGQYSGDRR PFPERHVHII GFASDVEIMR SLKKPKKICI QGDDGRDYKY
LVKAGEDLRQ DERVQQLFDL MNGILQKQHQ CSRLKARIRT YRIVPLSIKL GLIEFLPNVV
PLQQFFMGES LRKEYQTIAM DMFTEGPGKI LLKAAGEASS PLNHMTYWRS FQNISPETAA
RRFSEVVKKI PDHLLRDQLL NCCVSPDVFC FLRQKFTVSL AIMSIANYLL EIGDRHLGNI
VLDTKTGEVI GIDFGYAFGA SLQYLPIPEL MPFRLTKQFV GVVEPVGMHG LLESTMKYCL
KAFRDSSYIL LNTMDTFIKE PSLNWIVEVR RQIGEGRPLW NDETNLRDLF KWYPEEKISA
AARKLRGDNP VIIMQDELMN SRQHLSSFPL HQIINCIYGK KDFSALTEEE QSAPRGYPLQ
ALTVEQQTSC LIEMATDPII LSRTWFGWEA WI
//
