ID A0A0V1CP07_TRIBR Unreviewed; 1501 AA.
AC A0A0V1CP07;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Antigen-like protein {ECO:0000313|EMBL:KRY50732.1};
GN Name=CD109 {ECO:0000313|EMBL:KRY50732.1};
GN ORFNames=T03_47 {ECO:0000313|EMBL:KRY50732.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY50732.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY50732.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY50732.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY50732.1}.
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DR EMBL; JYDI01000142; KRY50732.1; -; Genomic_DNA.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF179; LD23292P; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 492..627
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 752..843
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1352..1441
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1501 AA; 167747 MW; 09103D7B9ECD63AD CRC64;
MNTTSPSACL LLKIFQLPLL FLSLLLLLFL CDGAIQQNYT GSYVILAPRL VRPNLPYVIS
VNLLESRQPV VIRARILDSQ NQSIAHTWGQ DLQSGKLTEV RIEKIPSHLP PETVYTLFVQ
GETVSGRVLF QKSAKLEFVH KSLSIFIQTD KGIYKPGSDV HIRVVVVEPN MKPYKGAANI
TIMDPSGNMI VQHLDVPIVA GICGMNDSLM LRLTSAPALG QWQITVDVDG ETQFQKFTVE
KYVLPKFEVK VTPPSVSTIS DDITVFVSAK YTNGRGVEGN VTIKAEYPWP YYGSEELQDV
VKKTTLDHVG EAAFQFANEE LRQKKLINEY GYNQIKFTAI VTERLTGETR NGSSTVTVHQ
HPIKVELIRS SDFFKAGINY TFRVAVKTQD DKPFISDSHS DIFLSVDFII RQLHHHNENT
TADFANFTIF DPKREKYNQV VKLESDGTQV VTISTPFNAS SMRIEAHYGG EESNVYTFDY
IDASHSPSNN FLQIISKQDE ISDQKFLTFD VIASTVVKEV YAFVIARATI VWSGQVVFEN
FKATLQIQSS KEMIPKARLL AYALIPDTKE ILVDALDFKF SNGFSDQINL SITPDTVEPN
ENVTFSINAP PSSYVGLLVV DQTVLLMQSP NDITLEAVEN EILSYELFSY GYHGLTQVAI
DRRKKRTICY RCGVFGAGSK DAYSIFQNSG IIVITDAFLY QQLNSPFLFR VAAPALASLS
ADVDNDLMVG SVMTKSGSTS LNVRLRSHFP ETWIWADLFA NEHGLAVYNA VAPDTITSWI
ASAFSLSDQY GLNALSDAKK VTVFRPFFIR LQLPYSVKRG EAIALQVLIF NYLDKDEKVN
VILDYHKDSG FEFIVKKSVS SSMIKKSVEV KPENSKTVTV GTLKLSVKAF AQSAADAIQV
PLLVEAEGYP VSYTRSFAID MKERNTFKQS FQLDHPEDMI DDSMKIEVSV IGDIMAPVIK
NLDSLIHMPD GCGEQNMIHF VPNIAVMQYL ISTNRLESNL KQTLLRYMEA GYQRELTYRR
NDDSYSAFGN ADQQGSTWLT AFVVRSFSEA KSFIFIDEEK LKLSAAFLAN QQKENGMFEE
NGQVLHSGLQ GGSGQGGVPL TAYVYIALLK TGTNNLEALN YLEQSLDYIS NNTYAVSITA
YALHLANSSK KDAAFYLLEK LSNSKDGRKF WAAESSSESN NGKNMSWYEK PRPADVESTA
YALLVHVLRG EASNAFPIVR WLTMQQDAFG GFSSSQDTVV GLQALAAFAE ATYSANVEMD
VTVKNGNEEA AFAINSKNSL VLQTYEIRNF VERQIDIFAT GRGLAFAQIK WRYNVKSLDN
NRPFFCETDV SQQAYTALTV SFCCKYMFEG TSNMAIMELT APSGFVIDVQ QLNGLTDTNQ
LQMVETKKQD TQANIYFDSI GISPICFNVS SKLAYQVADQ KPAIVRLYDY YEPQNRIEFE
YKVKKEVSIE DACGDSCYAE ISSAALTEQP ASKGTMPNCC SIIQTLPVLI YLFYYSVLRF
H
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