ID A0A0V1CRR0_TRIBR Unreviewed; 3204 AA.
AC A0A0V1CRR0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Lysosomal-trafficking regulator {ECO:0000313|EMBL:KRY52005.1};
GN Name=Lyst {ECO:0000313|EMBL:KRY52005.1};
GN ORFNames=T03_18189 {ECO:0000313|EMBL:KRY52005.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY52005.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY52005.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY52005.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY52005.1}.
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DR EMBL; JYDI01000113; KRY52005.1; -; Genomic_DNA.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 2390..2493
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2500..2799
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3011..3045
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 2800..2823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2800..2817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3204 AA; 364938 MW; 51F34C421DA60D55 CRC64;
MSDQFTTFEN AFLKKVAISQ PYLCQFLVEK FEEYLYVLNE GILTSQQAWP VLNEDYLPLC
CVLSLCKWKN VQKPNSMAEI VWNVIKTLLT DEDESVTFST PLSEANLKLL NLLFHYAGDQ
DLLEQKRKLL DYSSVVRRTA EDSKKSNFFI KERRAYVKWK RSRRMCLDDS NFSNERQSNI
WKPLYCTSTS SGDVSESGRP HGRISRMKHD SSSQPCLETN LWYWFVEDSD GFLWDSSVIF
HAADLTHIIG RQLRRQCRLF QSCSFDQLDK QTACCILLNL LARCINWCST EDAILSTIIH
DCTEWILQSC GVLSELHHMD GYLWLVRFVC KLISWMPVSG DYYFPSIRIA QQVNNFVWKL
LQCIVVDQLH NCIPSTAADQ SELLSDVIFT ACRAVVDNLL ILIFQMSAQR HLCDRMPALV
DLIDSSLSSR MLLDIPLQVV SSDVPRLLSS LDAWNRYLRD ALVAIVDRLL KLNRLAQHQG
WCSKSKHISC GLLAVAEEST DCITSVGSCC VILRIEEIVF ELVRRTRDNA PDDRFHMIRA
LFEFQSCSCS GVVRYLDLLV EMLPRCGSAV DRRMLRRCIF GKLLKQRSNN TLWNDCERFD
LASSFGQLFD QLNLCEQLPL LNLLTEAASK LTSDYKAQLF AGFALPQLLN ACRTDNFPVR
LVRALYRLCS TTITASNYPT LVEHFELFES HLREIELDLV SAELLIEAAR VERHVQEPHL
VSISDRILMQ TIRVLNLVIS DVRLLAMDNC NDRVTFWSAP ARLTYLCSRL WPLPHFAVSF
CQRGGVELIH GLVASVIHYS TRRRLDLDAT FFSYVEHLLY ITVGFCASIT PADSKIANTF
FSRVRNQLMG DLTERNPNNL LAVAEILLRT FVAVQLAESG NLLDRIKVDS GSSSGMSTQS
EEDVAAYSCV SYSSAKETAL QIVGNSYSIE KYSLAIGQWS IIIVAGLLKR GIENVGKFFQ
RLQRYCVRYP TMMKILLEHP TSIENFTTIL KTIPQCWTCE HVSPILEAML TIFLSINDHN
GLRLAFQLAD QYGSHTILTL LRILDQSLQE CKFDPKYLLP LNFPWPDDYS HSSCSTTASA
LAAACEKKSS GQQLLDLSFN STCSSYYTSM LRMIRMKTSA PVMINLKKYV KRANMRQGLS
VGIWLRCGIV GNFFNQACKR REQAHVVSIG NAKLLCSVNV GLPGLELILS LNFNGQQVVS
YKCGSLHADR WCLLFLQMRY ANQKLFIQLN FNDSRIFRRE THWNAEGDDD DDDDDEEEEQ
GVEDGTDAFR HFAIALFGRR KLFRLFGHVA SINVFNECLS DNYCTLLYEL GPRRCNLALN
ENGELLNLNL YCCSSKRKLY SLFDDEDALI RLSERLVAVM TGQKMIQFCA YPNKRYALNC
LCNVVVDHDD TTRSDRQQQT LLIDIVDPCG STQLYNFLQS CGSAMILLYL VIQVLHKPID
EQSRSFALRF LVLCVQRNPI WRDEFVKMLG PAMLSYFTGE SQFPVGSDFV KTLFDLCVSC
SHSGCPLICE VEILFQMLTS FQLWRNGLEQ FAEALLLLAN LLEASSENVT ICNQFSLIKR
LLNLICIYIR ITGKDFSSSL INAITRVVQA VLSAGIWFTE VSAVIEFLFY CHDASRVTVQ
YPFCNAFTWI NLSLIETFVN GLLKIRDECE NELLIKDDCG FMSSMHLYDA ASVTKQLHNT
TISDVFSKYQ LFASAGKMFF ELIEPSLRPS SKGIETFPAF VRLKCEILHL LIAHMNNIEN
GEQLTNVPNC DIRWEYLIVM LRQQVDRQTV GYLVELLAVT LHWFSDDQKK QFLNVRGFDL
LRNQLYQLPT SITVINSLLQ LVLGGQTSYF SNNNNNKFED QQLFQDHISN LMTIDEFQTE
ALSVLVAQLE CAIVDCTTFN SLIDLLTEIS KNDQIASTLW RVGLTDCLVA ALMKLPRLNV
EKDEDRQQQV MVNVRGAWRR FAVSVFRKAL LSAEEQVFKC AAVGFLELLM LADLQLYVGG
KVVKQKLIRD ELVNLLGELL TTYRQVSWLK RWDDRKSSTS CRRHRCSSGE AGESEIMASR
LEDRLVECLE LCNNFILFMP PNVGPDNDEE LLLFQSYFSF LIDLIPDSFL LTKDPPNGPK
KRLAIFALVK NLFVFLVHPS ILLTFRQLWD RLHGNFRQTA GNCCDCSRRF VMVEQLQRNP
KAREVLKSFL STLPEYRDLL LHIFCDFSVC TTLTEADKAA LAAFLRLDFL QASSVSSSKL
SSSGQCKIEL APAKSSLKKF YHLTCSWVSG MFERKKRILQ DSQTRLHSTN EQASDVNRFT
VYMHDVITSE YASFEHNSNR LAENVLWQWR FIEKSLCHPQ GIFYSPKKWP NRWYLDPLHL
PGYSRVRFTP DVMDNDSEFY RSQETGSSIK GCSSFWLDKL FATSTLLPFD TEGGVLHSFN
TIMVTLFFEA TGTLLLYRDK IHFLSNNCCT VQKRIPLNKK VSTSWNYSQL ILLNCLRFHA
ADSAVEMFFD TLESCLFVFD SPANRAEAVD HLKTFSPSLQ QQASLQMLST FTEAWRYGRM
TNFDYIITLN ELAGRTFNDI TQYPVFPFIL NDYLNYTIDL KQPTLYRDLS LPVAVQNSKS
RTYYSERYEA LSSASLDQNV PLSEPYHFSA LYSNSGVVLY YMIRVPPFSN LALEYHDNTF
DMPDRLFHSI NTTWNMASWD WRGDNKELIP EFFTLPEMFI NTQNFNLGIR HNGERVHDVI
MPNWCPEKDP RLFVLIHRQA LESDAVSKRL SHWIDLIFGY RQSGQAAVEA FNVYHPCTSW
KNVRFEELGD EIFSNALHAM VKTFGQLPLQ LFTKPHPPRT ISINNDSNST TASAAAPRPP
PTSEYSFCPA RGLRWGNYVG SPEGQAPRLI CAPTVVIDAP SQLAHVFILP CGNLVFVPDK
VALVAVYPCK LNPNRTFFSS VRQQVRLRTP VSIVSLRFDF ADCVIKLKFE HLPTSAGRIS
ESDLSELNDL MLAYDFQVTA YSSFVETTVF CFGTDLGTLN VVRLKWDYFP NVVKHLQPQN
LQANCTVLKT LYGHSASVST VAQSTEHGII VSGSAAGELF VWDLNRLCFV RKLTGHEGTL
SLCAISSGSS SSCDIVSVSD EDVGSELILH TVNGRLVGRV HSSVTICSLA LSTLAEGVSI
NCIAAGLQNG VIKIWDRWKL SLIQELRSDE VLRPVISLAY TCNCSQLVAL LNDNTIICWD
KNADTTKSAT NHFKERLSRA LRIT
//
