ID A0A0V1CT11_TRIBR Unreviewed; 492 AA.
AC A0A0V1CT11;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|EMBL:KRY52363.1};
GN Name=bmp4 {ECO:0000313|EMBL:KRY52363.1};
GN ORFNames=T03_1799 {ECO:0000313|EMBL:KRY52363.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY52363.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY52363.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY52363.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY52363.1}.
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DR EMBL; JYDI01000106; KRY52363.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1CT11; -.
DR STRING; 45882.A0A0V1CT11; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13760; TGF_beta_BMP2_like; 1.
DR Gene3D; 2.60.120.970; -; 2.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF263; PROTEIN DECAPENTAPLEGIC; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..492
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006876181"
FT DOMAIN 378..492
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 237..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 56112 MW; 8E3A0273EE41BB33 CRC64;
MRFGHCTPLW FEPLPFLLHL LILLNIFCCN SISLSVAEMT TTVTTFAGKK SPELSSSPNG
QLDQTDLERL ERHFLRVLNL KSRPRPTVKA KVPARLQALY EQLTNEQNSA QSLPVPPFWN
NARTFQPKSD ESLSESDMLR FDLHTLPPDE VLEGAELSVF VESSRRRTRA ETPALLSNEK
RVLDERNRKV NRKEENQLSM TRVVVVENKT NKKQKDILMI NQDNRGGGIS ELEFELDLEE
SPKSEEETSK KHRRRHSARL RLDAYELVRN HSVLVDTVLV DCDAGERWVS FDLSATVRRW
LMSPYKSGTV QLRTTGSKSD CHFILLQSAK LSSRSPLLTV MTSDADSRAN SNGRNRSKRR
AAVPSKPKAE RRHGGGGRRH RHKTYRRRQL CQRHELYVDF ESVGWNDWIV APPGYKAYYC
QGDCPFPLND HLNATNHAIV QTLVHSVNPG AAPKSCCVPT ELSPISMLYL DEYDKVVLKT
YQDMVVESCG CR
//
