ID A0A0V1CWN1_TRIBR Unreviewed; 2701 AA.
AC A0A0V1CWN1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=itr-1 {ECO:0000313|EMBL:KRY53107.1};
GN ORFNames=T03_1892 {ECO:0000313|EMBL:KRY53107.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY53107.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY53107.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY53107.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY53107.1}.
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DR EMBL; JYDI01000093; KRY53107.1; -; Genomic_DNA.
DR STRING; 45882.A0A0V1CWN1; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2269..2291
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2303..2320
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2326..2353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2360..2376
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2396..2420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2440..2462
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2542..2561
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 120..174
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 246..302
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
SQ SEQUENCE 2701 AA; 310564 MW; C62193CBDBE0CED8 CRC64;
MSAVDVFSST FLHIGDEVSL YAEGSDGTNG FLSTLGLVDD RCVVRPAFGT PENPPKKFRD
CIFKICPVRR YAAQKQLWAE ERTRQTNGMS SMTLDMMMRL KDAAEKEREQ NQLEFEKTVG
QIVQYGTTLQ LLHVKSNKFL TVNKKEPARV DRNAMKVTLD AQGNDGSWFT VEPFYKLRSL
GDNVVAGDRI CLVPYYVAQI PGSQKHQLHV SSLSLAEDSE SKEVNCLNDQ TCWQVLLFLE
YRENLPDVLK GGDVVRLFHA EQQKFLTQDS RNGVQTVFLR VTKRDQALEA TSSKALWEVE
VIQQEPHKSG AAKWSSTFRF KHLATDMYLA VLEDEQSKKK PFPMSKEFKK KSSKSSSMEP
TYSLVSVIPA SPRDPATLFQ LDPTTLTKMD AYIPRQSYIR LKHVQTKNWV HSTTTRCDPE
KGDESVMLKL GCSNWKEDKE AFAILSVMPG EVRDLDFAND ACKALADFLQ RIRHGLNVMK
EKGMIMELLA ELIYFVTNAK NHLEDPLKIK PNKVNRNRQK LLREQKVLAQ IFDLLRAPFE
SRKDQRPLFE NPSVLSKPGN ESFKRMFQLM YTVLRFSQQS YRRNQVYIAE RFIDIQHQIG
HGLMAEDTIT AVLHDNAKLL ETHVEKTHIE KFIELVRQNR EGRFLDYLTL LCVCKNEANK
KIQELICLLV LNDANRDILL ETRMFGDQVF IGWLNDESEE LEKLAYETMN SPEAERIVNY
YKHQLDLFSH MCLDRQFLAI DPPANKHLLN LSQELPISVI LRCMVNERLP YDLRANFARL
MLHLHVITDL QEVMPVRYAR LWKEIPETVS VEKYTNEEIY SFNQKQRRLF ARSRFTGLLT
YVEEYLRHVK TAKFSHKAQN VFTLEIVNLA HALVKFGFYS LPELLVLAQD LLDILDNCSL
DMERVSNGAV VGAVVPNRTE ENMKMEVSSF IESEKQPSDH EDGKTVNLKT KLTIVEILQY
VLNVRLDYRI TYLLSLIKKE YASSDTGDVG FYEDLDDLKI TQFAHEVFYS KSHCVEVDVE
KEDFNCRLEL GRENGKQLLR ILLQIMLSDY PPLISLGLSV FYQSFNQRNE LVQALKQLQL
LVSQMDVQNY QQVHRDLVLM KNLVEKSELW VYSAKTGSQK RSLFPITNDK KSTEDEPLQR
FDNDLVELIN VEEEKKNMMK LFKELNCKYP MSSEHCRKLL SDILNNWVKL CYADERRPDA
RNQQLLRNMR VYEVVIEFLS IPFDKKIDSE MPKLFDLAHQ FLCGFCNDNE ENQRLLHQRL
SLNTDASKCD YLAIEEPRDI ETLCAIFRGN RELCANVSDQ LIQHVVHLIE SKGRNAIFLQ
FLQTLIPEER TISLTQEKIS QVISTSSEDV CLFYTDSAGF EAMMSLMKQS VDLSDLCNPL
RYHIELVRLL ALCTVGKNVT TELQCASHIP LEHIVRVITD EQCFYEIKEV YLQFLLHCYI
DTDADMKDMY CDDCMAQILA NVLDDVEQVL LLLLYERGPS INGSVERYIC LTVTKLLICF
FEQPCAQCFS DPKHENGIFG RLLEALGRLQ SIDWLRRQNA IYKSNLINCV ETMCKFAIIY
LFSFPCFYWI GAHDQRLAVT VDMIMRKEGK SSKWTKLKKA KYFVTQAAHM TRKGHDFNNI
VDCFHEIVCR MEDLFGPMAR AETMVAVDVL HYPDLTFYDT QSNMKRYSDG EFVTKLIKHC
RLLAYDKNEQ LCIKLLDTIR SMIPAEQDLD TSTMNSRKDL LLQYLGIHGP GRSGKAKSFK
DDDQERWTTM LKKILPQNIT SVQCSLNAAG ASKLVIDLIV HCSSENIFIA AVELGKTLLE
GGNRVVQNSF LECLTSGGVG ENFFRVFNEK MQRAQNKLRS SILSRRDRIG GSRMTSRSFM
SGSSQTSAVG QAHDEAIRKI QDQLKLWSDD DWVGGSESSD IRTERCWREQ DKVDADFLLP
AEVTIMEPIL RLLQLLCENH NPALQNFLRC QENRTNYNMV TETLMFLDTI CGSTSGSLGL
LHEINEHNVS LVNQALISLT EYCQGPCHEN QNAIAMHESN GLDIIISLVL NEIMPLAEKN
IQLALEIKSN ASKLLLAILE SRNDCDNAER ILRNMARMAG GAEQLVSAIT DVFKLPEISF
NHSGYAEKIA SQFDTPKIVF ETKTDINGNP VENDGYCEVS PSEVGHNIYI LAHQLSKYYP
KLNSMLKPSN ARDEISRSAL QFYTDHTAHI EVVRSDRSLE LIIFPVPHVC KFLTEETKER
VFLKTERDLQ GSKVPEFFAN FDTLYNEIVW QQKLRDKPWL YKCSRSVPIW MRMSFIFAMI
LNFLVALFYP FDSAFGAAIN TEISGFYLLC LLATTTYTFT APTWTAVAVT STFVASSCVS
LFGVTVASYL FGLLQVRHRI IANNIVHTVG IIGSYGPMKL TLASFLSNSN VVYNMFYLLL
CLCGLFVHEF FYCFLLFDIV LHEETLCNVI RSVTRNWRSI ALTGILAVIL VYTFSMVGFV
LFSNDFWIEV EPNDQTCAQS ENCTETTNVP GEPVKVPFCE SLRTCILAVL RWGLSSGGGI
GDVLRKPHPQ EPLFYMRILY DLSFYFILIV IVLNLIFGVI IDTFADLRNE KQENEEIIRN
TCFICGLERS HFENKPVSFD EHIKNDHNIW NYFYFYVLLN TKSSTEFTGP ESYVYDMIKE
GNVDWFPRMR TMKLAIQEGD SEQTEVKILQ RMICERQEEI SNLAARIDEL KQMVLKLSRS
K
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