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Database: UniProt
Entry: A0A0V1D2J8_TRIBR
LinkDB: A0A0V1D2J8_TRIBR
Original site: A0A0V1D2J8_TRIBR 
ID   A0A0V1D2J8_TRIBR        Unreviewed;      2174 AA.
AC   A0A0V1D2J8;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   22-NOV-2017, entry version 11.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=Ca-alpha1D {ECO:0000313|EMBL:KRY55668.1};
GN   ORFNames=T03_3929 {ECO:0000313|EMBL:KRY55668.1};
OS   Trichinella britovi (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY55668.1, ECO:0000313|Proteomes:UP000054653};
RN   [1] {ECO:0000313|EMBL:KRY55668.1, ECO:0000313|Proteomes:UP000054653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS120 {ECO:0000313|EMBL:KRY55668.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRY55668.1}.
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DR   EMBL; JYDI01000052; KRY55668.1; -; Genomic_DNA.
DR   Proteomes; UP000054653; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054653};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    235    256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    268    288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    328    347       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    409    430       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    442    464       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    573    589       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    609    634       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    641    659       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    696    716       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    737    754       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    766    789       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    935    953       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    973    997       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1009   1035       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1070   1089       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1180   1207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1261   1279       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1291   1311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1331   1348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1360   1378       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1424   1444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1510   1534       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1690   1724       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2174 AA;  248453 MW;  ED19D16E49D9A1D8 CRC64;
     MLAGGETLLQ IEFSWLLWSR RRSRASYLCW HRESRPEQVV PSPIAEPRVA SIQTMIVRQV
     RHHARSEANF NDDVNIGKEL SGNEAAALLH GDEARASRAD LWQQTLQAAV AAQTESSTTT
     KKRQQQRKMQ RNVQQERPER SLLCLGLKNP IRKLFISIVE WKPFEWLILC MICANCIALA
     VYQPFPAHDS DRKNAVLQNR KHKLNPQPGQ RTATVAAVGH TGWGVGLFSE EQVEYIFIVV
     FTIECVMKVI AYGFLFHPGA YLRNGWNLLD FLIVVIGLIS TALSTLNIHG FDVKALRAFR
     VLRPLRLVSG VPSLQVVLNS ILRAMVPLFH IALLVLFVII IYAIIGLELF CGKLHKTCVD
     QWTGEHVPDP GPCGESHTSF HCDRSKNLVC TENHTWPGPN DGITNFDNFG LAMLTVFQCI
     SLEGWTDVMY WVNDSVGREW PWIYFITLVI LGSFFVLNLV LGVLSGEFSK EREKARARGL
     FQKFREKQQL EDDLKGYLDW ITQAEDIDLV NEEDEEQEAM DREEFGADGE GGEEGGSKEE
     FQRQSWFSMK IKRLKKLNRR CRRSCRRIVK SQAFYWLVIV LVFLNTMVLT SEHYGQPEWL
     DHFQEIANLF FVVLFTLEMF LKMYSLGFVN YFVALFNRFD CFVVIGSILE FALTFAGLMK
     PLGVSVLRSA RLLRIFKVTK YWNSLRNLVA SLLNSLRSIA SLLLLLFLFI VIFALLGMQV
     FGGKFNTIDP NMNKPRANFD TFVQALLTVF QILTGEDWNA VMYNGIAAFG GVHSIGVIVC
     IYFIVLFICG NYILLNVFLA IAVDNLADAE SLTAAEKEEE NKRANEADPE DDMVVKATAD
     EDAVSVGQFH ESGEVKLPFN EPTDAEDEHL ASGDDDQERE MENQSQFKPT ARPHRQSELN
     LPKKTKPIPD ASSLFLFSST NKVRIFCNKV INHSYFTNSV LVCILVSSAM LAAEDPLQAS
     SFRNEVPKFV LNYFDYFFTT VFTIEISLKV LVYGLILHKG SFCRNAFNLL DMLVVGVSLT
     SFGLKSGAIS VVKILRVLRV LRPLRAINRA KGLKHVVQCV IVAVKTIGNI MLVTFMLEFM
     FAIIGVQIFK GSFFRCTDRA RLTAEECKGT FIEFEGGDVT RPHVRNREWT NYDFNFDNVQ
     NAMVALFVVS TFEGWPDLLH VAMDSSDEGI GPQYNARVSV AIFFITFIVV IAFFMMNIFV
     GFVIVTFQSE GEREYENCEL DKNQRKCIEF ALTAKPQRRY IPKNRFQYKI WWFVTSQPFE
     YAIFIIIILN TLILGMKHYK SSAAFDEALD VLNLFFTTVF ALEFICKLFA LTFKHHKMTR
     TFDDVLDTMN LIFTGIFAME FILKVMAFRC KNYFGDAWNV FDFIIVLGSF IDIIYGKVSP
     GSNIISINFF RLFRVMRLVK LLSRGEGIRT LLWTFMKSFQ ALPYVALLIV LLFFIYAVIG
     MQIFGKIALN SNTEIHRNNN FQTFPSAVLV LFRSATGEAW QLIMLSCANT PAAMCDPESD
     DRGQPCGNDF AYPFFISFFM LCSFLIINLF VAVIMDNFDY LTRDWSILGP HHLDEFVRLW
     SEYDPDAKGR IKHLDVVTLL RKISPPLGFG KLCPHRLACK RLVSMNMPLN SDGTVCFNST
     LFALVRTNLK IYTEERPFLF LKKSEKVESQ SLVSSNIEEA NEQLRAVIKR IWKRTPQRLL
     DEIVPPSGRD DEITVGKFYA TYLIQDYFRR FKKRKEVEQK ETNMQGNITM SLQFGEEFLS
     DLEAFDVLIV FLHVLLLQAG LRTLHEIGPE IKRAISGNLE TDWSKEFEEP QHRRDHSLFG
     TLVHALQAHY KPFIEGNLTN PAYSNVNGDL KSQEGDDEAE QQHQQHQQEQ QEQQQQLMFN
     KMNDLKSPPV KSDRDKISEF ESDESVCNKP ERRCNSFFSN IRRRMDSIVS PSIVLFDSDH
     DSSEHEMQER VRFVPRGSKP TGLSFEGSRW LPRKLSFRRT PIGGAAAVSN LQQGNNKRLQ
     FSNAIILDDS DPDSVLHSEN VVDLTESGDD SKLSVSPPLE LRDDAYYLDG IDYNTWRPAP
     MGQGVRLRGR GNGRRKSRSM PLPHHEHQRN YADVLVEKVL ADQGLGRYAD PNLIRTTQLE
     IAEAYNMTEA QMHSAARSLM QRSPKYFEHM GGQRPADIKD FNQYSKTALL KPREINSSEE
     VDISDDMNMF MSVV
//
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