ID A0A0V1D6Q2_TRIBR Unreviewed; 1283 AA.
AC A0A0V1D6Q2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Neuropathy target esterase sws {ECO:0000313|EMBL:KRY57044.1};
GN Name=sws {ECO:0000313|EMBL:KRY57044.1};
GN ORFNames=T03_3628 {ECO:0000313|EMBL:KRY57044.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY57044.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY57044.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY57044.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY57044.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDI01000036; KRY57044.1; -; Genomic_DNA.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 3.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR Gene3D; 2.60.120.10; Jelly Rolls; 3.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001423; LysoPLipase_patatin_CS.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR14226:SF29; NEUROPATHY TARGET ESTERASE SWS; 1.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR Pfam; PF01734; Patatin; 1.
DR SMART; SM00100; cNMP; 3.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 3.
DR PROSITE; PS51635; PNPLA; 1.
DR PROSITE; PS01237; UPF0028; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..216
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 377..482
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 526..590
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 812..978
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 1283 AA; 146834 MW; B1D387C9934B391B CRC64;
MDAFMQFIQL LYENLKIITI GMGCIFITWV INRFMRLNVA TSSATKYPVT FSRKSSFNYR
FRKRDRMLFY GRKLMRKVTS AVINGDKKQK LRKRDRVFRF ASKFLRPQKK DFTARPIRRP
PDAFLEADTS LPVSPKSVQL LNMLKSIRIL GHFEIPFFLD VCKHIETKRF AADQFVFKDG
EIHDCIYIVE SGRLSLFIKD EKFDFEVKSV GRGDSLYCSL SILDMIKNQA RPMKNVFAKA
TEESVVLQLK SSVFNDIFDK YPESWTRTVQ IILLRFQRIT LATLYRYFGF TSELSKTVQL
YRIIFLLLYG LNFQSIRAVS KLSPLQEQSC KDFREIKSEN EGATPEDCTA SENAFPTFGV
STTDDDSDIF QVAIEELAKL FGMKEASFLV DKVKVENFEP GIMIVRQGSN ELQLFYVVSG
MLELLLESQE DPDVLLPISI VQTGDVIGGL SVLSGEPSFF AVRTRSFCQL AIVERKSLYE
IISEYPRVVV NVASTAVESY SDFVKEFDMA VEWEICESGK ALYKLQNEQA DALYVVLSGR
LRSVLTREPG TREVLNEHGR GDVVGLVEIW TLRRRSTSVI AIRDTELCKI YATLMNFIKN
KNPQVLSNII RLLGHCIIEQ QQQTVPLTGF TVELWNALNS ITPTELFSSY TLQDMLGPTA
LDKVNEYQII TWLNQQEDGN SIVLYQCDVE LTTFTSLCIR RADCILIVAN GEQEPMVGEI
EKELENLTVR AQKELILLWH DSTDRPRRTA EWLDLHGWVS SHYHVRFRDR VFKQRNPRRM
LRYKERIIRR CDNRHTDIAR LARALTSTSV GIVFGGGGAR GAAHVGIIKA LKDHGIPVDI
VAGVSIGAFV GGMYCLDSDV PKLIMCAKQA FKEAASFWAR LFDLTYPVSA LFTGKALNRL
LKSVFNDVEI EDLWIPYFNV TTDITSSEMR VHRSGKLWRF TRASMSYIGI LPPLCDPLDG
HYLVDGCYMN NLPGTLWRYC RASMSLAGFV PPIFDLTDEH LLLDGGYVNN LPADVMRSLG
VRTVIAVDVG ALTETEFTNY GDSLSGWWAL WKKYNPWASP VRVMSMAEIQ SRLAYVSCVR
QLEEVKKAPY CHYVRPPIDK YQTFDFNLFD EIFNVGYWHG KTLLEEWKSS GKLQEVFDGR
SANLSKFAQR EKFKRGFAFT SAQSFTDLAA MVSKIHRPFE TSLDEISEEE GDDRIPLDLI
HTTSSSSYYN NNLKMSGHRV VISRDDVDQF DKLLEKSGCA KEHYVLQDCY AEHKDWRKCK
KEIDALRKCM KVEDRTESAD NAT
//
