ID A0A0V1D7S8_TRIBR Unreviewed; 1299 AA.
AC A0A0V1D7S8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Neuropathy target esterase sws {ECO:0000313|EMBL:KRY57043.1};
GN Name=sws {ECO:0000313|EMBL:KRY57043.1};
GN ORFNames=T03_3628 {ECO:0000313|EMBL:KRY57043.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY57043.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY57043.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY57043.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY57043.1}.
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DR EMBL; JYDI01000036; KRY57043.1; -; Genomic_DNA.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 3.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR Gene3D; 2.60.120.10; Jelly Rolls; 3.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001423; LysoPLipase_patatin_CS.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR14226:SF29; NEUROPATHY TARGET ESTERASE SWS; 1.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR Pfam; PF01734; Patatin; 1.
DR SMART; SM00100; cNMP; 3.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 3.
DR PROSITE; PS51635; PNPLA; 1.
DR PROSITE; PS01237; UPF0028; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..216
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 360..461
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 516..580
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 828..994
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 1299 AA; 148296 MW; A2E23485A4488391 CRC64;
MDAFMQFIQL LYENLKIITI GMGCIFITWV INRFMRLNVA TSSATKYPVT FSRKSSFNYR
FRKRDRMLFY GRKLMRKVTS AVINGDKKQK LRKRDRVFRF ASKFLRPQKK DFTARPIRRP
PDAFLEADTS LPVSPKSVQL LNMLKSIRIL GHFEIPFFLD VCKHIETKRF AADQFVFKDG
EIHDCIYIVE SGRLSLFIKD EKFDFEVKSV GRGDSLYCSL SILDMIKNQA RPMKNVFAKA
TEESVVLQLK SSVFNDIFDK YPESWTRTVQ IILLRFQRIT LATLYRYFGF TSELSKTSIR
AVSKLSPLQE QSCKDFREIK SENEGATPED CTASENAFPT FGVSTTDDDS DIFQVAIEEL
AKLFGMKEAS FLVDKVKVEN FEPGIMIVRQ GSNELQLFYV VSGMLELLLE SQEDPDVLLP
ISIVQTGDVI GGLSVLSGEP SFFAVRTRSF CQLAIVERKS LYECVTFLNR IISEYPRVVV
NVASTAVESY SDFVKEFDMA VEWEICESGK ALYKLQNEQA DALYVVLSGR LRSVLTREPG
TREVLNEHGR GDVVGLVEIW TLRRRSTSVI AIRDTELCKI YATLMNFIKN KNPQVLSNII
RLLGHCIIEQ QQQTVSAVHR EPLAHVSNLN TIAVLAVSDE VPLTGFTVEL WNALNSITPT
ELFSSYTLQD MLGPTALDKV NEYQIITWLN QQEDGNSIVL YQCDVELTTF TSLCIRRADC
ILIVANGEQE PMVGEIEKEL ENLTVRAQKE LILLWHDSTD RPRRTAEWLD LHGWVSSHYH
VRFRDRVFKQ RNPRRMLRYK ERIIRRCDNR HTDIARLARA LTSTSVGIVF GGGGARGAAH
VGIIKALKDH GIPVDIVAGV SIGAFVGGMY CLDSDVPKLI MCAKQAFKEA ASFWARLFDL
TYPVSALFTG KALNRLLKSV FNDVEIEDLW IPYFNVTTDI TSSEMRVHRS GKLWRFTRAS
MSYIGILPPL CDPLDGHYLV DGCYMNNLPG TLWRYCRASM SLAGFVPPIF DLTDEHLLLD
GGYVNNLPAD VMRSLGVRTV IAVDVGALTE TEFTNYGDSL SGWWALWKKY NPWASPVRVM
SMAEIQSRLA YVSCVRQLEE VKKAPYCHYV RPPIDKYQTF DFNLFDEIFN VGYWHGKTLL
EEWKSSGKLQ EVFDGRSANL SKFAQREKFK RGFAFTSAQS FTDLAAMVSK IHRPFETSLD
EISEEEGDDR IPLDLIHTTS SSSYYNNNLK MSGHRVVISR DDVDQFDKLL EKSGCAKEHY
VLQDCYAEHK DWRKCKKEID ALRKCMKVED RTESADNAT
//
