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Database: UniProt
Entry: A0A0V1DDE2_TRIBR
LinkDB: A0A0V1DDE2_TRIBR
Original site: A0A0V1DDE2_TRIBR 
ID   A0A0V1DDE2_TRIBR        Unreviewed;      5123 AA.
AC   A0A0V1DDE2;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   22-NOV-2017, entry version 13.
DE   SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:KRY59582.1};
GN   Name=Rya-r44F {ECO:0000313|EMBL:KRY59582.1};
GN   ORFNames=T03_8903 {ECO:0000313|EMBL:KRY59582.1};
OS   Trichinella britovi (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY59582.1, ECO:0000313|Proteomes:UP000054653};
RN   [1] {ECO:0000313|EMBL:KRY59582.1, ECO:0000313|Proteomes:UP000054653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS120 {ECO:0000313|EMBL:KRY59582.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRY59582.1}.
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DR   EMBL; JYDI01000011; KRY59582.1; -; Genomic_DNA.
DR   Proteomes; UP000054653; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054653};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KRY59582.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4472   4497       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4672   4691       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4732   4758       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4876   4898       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4921   4943       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5002   5021       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    817       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1045   1226       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4223   4258       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4261   4293       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4236   4247       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4271   4282       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5123 AA;  583895 MW;  CA37B8E14444CC8C CRC64;
     MTDFQENSTG EQDDISFLRT GDVVCLTCLA PCKESGTGSA ERVSLAAEGF GNRICYLENV
     SDKNKPPDNA TSMFYIDQAL SVRALQEMMS SESPNISGSS STHRTLLYGH AVQLKHALSG
     MYLTCLSTSS ASDKLAFDVG LCETNVGEFC WWTIHPASKQ RSEGEKVRFG DDVILVSVAT
     ERYLHMSSTN GNTVLAAFHQ TLWSITPNSS GGVRERHMGY VCGNDVLRLN HGNDECLTIP
     ENWSDSHQNN IVIYENGKSC NQARSLWRPE LIHGKWQSSL IGWEQAFRIR HITSGRFLAL
     NEDNQVCLLH KDRASFESTA FIMISSKDVK RSTFEEKEEE GMGVATVKYG ETVIFLQHLQ
     SNLWLSCQTT AVTKKNMGKV EEKKAIAVEE ARMDDCFILF KAQEEESQSA RVIRKCSQIL
     NRFLRGLEGL QMEGKDSLAW NRADLSETVK LMEDLIQYFA QPEESVDFES MQNGLRALRN
     RQDLFQEEGL LNMIIDTIDQ FSAVESMTEL LDVTKEDKCK NWQDISTYLY LLVAAMIKGN
     HSNCTQFASA QRLNWLFSRL SNPQSAEGIL DVLYCILTES PEALNMINED HVKAVISLLE
     KVGHDPKVLN VLSALCEGNG VAVRNSQNVI CSELLCNKKF LLQTKMIDQV SSVMANIFVG
     SYENSAMYPR WYFEAELEYM ESMRTSGQKP HLRIGWASSA GYRAYPGSGK KWGCNGVGDD
     MFSFGFDGQY IYAGIAALKL SKLIGGIEKF VGTHEIRKGD VIGCSIDLAI PEIQFSLNGH
     QIGTSVRNFS SCDCLFYPVM SLSAIVSCRF FFGGSQGKLR FGPKKGYLPI SEAAITPVKL
     ISCISFGDTR KGYFAGPSTV ISDYIVFQPK PIDTKDVSLP KHLEDVHEKL AENIHEVWAM
     DKIEKGWIYG ERRSETQKTH PCLTSYERLP TAERSYNLNL AKETLKTIVA LGYRIDIGKA
     SNRVKTFRLG QNFLMSNGYK PAPLDTREYE LNETLETLVD LLAKNMHNIW AQSKIQRGWT
     YSKNENVNIK TTSHLVAYDF LDPNIKAANR DKAGQIIRSL LVYNYCIEPP TAEQDEGAVK
     QSQVMNLQKR TYRFEKRYAV KSGKWYFEFE VRTSGFMNVG WMDVSASPDG DFGLHKSSYA
     YDGYLGRKWH GESESYGKKW NVGDVVGCFL DLTDRTICFS LNGELLLDSS GTEVAFDNVS
     AEDGFVPAFS LAPGQIGRLN CGQNVNTLKY YTTCGLQEGY EPFCIRMSRQ APMWIAKCEA
     EFDEINEEEK RFKVTRIPQS GDNPPCLKLQ CKSAGMLERC SLALFRLNLP VFCKEANDNR
     VCNQYFTETL SERNAGKRNG ESDRTAESSR RGKMKGIRGS RNQDENISFH DQQNYADQYE
     VSNHAVMKSN YLVQKTFSLD DDSSEVTENR FRKAPRLRSS ASEANLKEKE SIDSQDKISA
     SYAVSNTKRN LRPFKVLQSF GQRMRDVSVG RSRKQNARKL QEACASKSKI RSDENDKFSS
     GHLNSRKLDD RVADVDSTES LDMPKSGPGR RPTVIRLESD SKVKKRSNYF SSGHDLLVEA
     SKLSAPSGNQ HVSIGASVSF YSTPDDYYFG VRVFPGQDLA NIWIGWLTPQ FSFTGSQIAA
     DSQRICFLES THSTLDNIQE FRSCYIVNGM ELLTAAGGSS SVSKMAGILA GCLINTATGE
     LKFHVNGKQT EMSYRVEPGT ILYPAVFVLP TSREVLQFEL GNIEKTLPIA SAQLNERSNA
     VQLMCPPRLK MEICKTRTWL RVPDQCARVT SLKLSDTRGW SVLCDDLVRT MMLYVPERDS
     SIDILELAEH ESLCTFHQQT LRLYCSLCAQ GNFKIAHILC QHVDEDQLMY AIQSKYLSGS
     LRQCFYDVLI AIHLKCHYDA RLAESHEYII PLNAKLKDRN YFNYETKSVY PHALNSDITL
     KSSINVMEVK KKISTEDEKF LMSPTFDFHT LKQYVVDALE EATLEALMNS RDLIGGTNTT
     HFLPILKLFD TLLLVGVLSD TDIHRFFRLL NPKSFQETLD SPQNVKGLVD LDLDEMVQLE
     LCHIMNHLCD LQLQGRVESL INFAETFVGE TQNACALDEI FEKSNLCFNY LRDQLRRYLE
     IKQTDMPSAE AARKTKEFRC PPKEQMLKLL DFKADRDEQT DEEGELEVSA MSEFLQRVLR
     EFHCNMVKFI GNSDKNDDNY SANVEQKQLE SENMNWVEKL AWMVVPVPPA LLSEDERIKF
     DGEEAFRNII LSTLIKWTGN KAIDDPNLIR EIFGLLLRQY TRISEVKSAL KTAYCIHERS
     IEDVQSFLDN LCQIRRLLCV QFEATEEEVL KNSLWDMMNN KVFFQHPDLM RLLKVHENVM
     TIMVNVLSRA QKSELDDRRN RSTQDDMKKA FQNSISDLVV ACCKFLCFIC RSSTKNQAAM
     FEHLPFLLDN ATMLLAKPSL RGSVPLDVAY YSFMENSELA LALKEDDLEK VAFYLSRCGL
     QANAEMVFKG YPDIGWDPVE GERYVDFLRF CVWVNGECVE ENANLVIRLL IRRPECLGPA
     LKGQGEGLFR AFKDAISLSS EISNLHKGRD LRSRFNFDLS HYPNPEIEEE DYIDLGAAIL
     GFYSSLADLL GKCAPDHLTV KSGKGESVRL RSILRSLTSV EDLEAILALR FLLPNVFAAK
     EESSRSSSIG LLPCHKQSIL LFLERVYGLI DKEMVFRLLE QSFILDFRAA TILDHPAYAE
     SDLALALNRY LCGSVLPLLT SHAHCFADAE HYYSLLEATL HTVYRMSKIK SLTKSQRSAI
     TEFLLAFTKE IHPGMMKKLL QKVVVDISSL NEFATVPLQI MTQHYECFSK HYGISMHEDT
     ASEEQKRLSM LLFTTIFDSL GKRAFDSDLF ASALPCLTAI GSALSPDYAM QSYAEEEIQN
     MNVPSGHMEV WRPHPVDASN VQLSVNLQNL VQRFAQHFHD SWASRKLEKG WRNDDIYSRT
     NCTHPRLKPF GMLKEFEQNF YKERCSECLK ALLAWGYSIE QETQVSSVQP KSMNPTSNVR
     SASVFCPQPI DLSNMTLSEE MCELAERIAE NSHLIWVSKT IEDLNDANTG IMVLLVPWDI
     LADSEKRKHR FRAQEVLKFL QYQGFRLKSP LHRAREEYQQ TVVDSNTHRP VEKRFACNLL
     EKLLAYLENA AQKMEVIKPS KQFSRYRNYT LPSEDVKFFG KVLLPLLESY FRSHRNYFTA
     ASSASLSGVA SIKEKEMVAG LFHRLMSVFR SKHNAFGCHV KSTVRCLQVL LQAIDFRSLV
     KINSDTLRTC AQIFLSNMVS DLMNITKEIK NNGRYAEIKG KTLPCTSSLL FLYEAMLPLL
     TTLFCHLSKH GHGQDFLVND IQVGCYKIAD CLYMLASPIT ISRKSVKEEM EKHRSSIGQC
     LSAFACCFPV AFLEGDFNPN SRGSTVDRQH LLSESKDTSS SLLLNIPSLD NLLSNIEQLS
     NTNGKYQDAP AIFDVDIPML CSYMSFWWQH GPTNNTQEKN LSAVSSDHIN RLFSACSRLI
     CDHIGIAHAD WICHLAPFIT PMINYVTIEP VRDYLLPMAE KVRMQADLAF KEEEKHRMHP
     DVFDESTVIE LHSILIRDVY ALYPILIKFT DLHRARWLKN PCWETNALFE HVAFVFKLWS
     TSQHMKREEL NFITQFESDF MTGTSRKTGK AAVAFRKKKR REGKRREKDS GSIVVACLKR
     LLPVGLSVFG GRELDLLQKV KEKYMKKEND EKIKEYISSS LAVPDQEDVF DKSHWQRKLY
     QQIGKAQMLG IDSMSQEMVL DKIIFMGVTL CNLHNVSTLL RVAVEFNRFK RIDAWRKIVS
     SQRKRAVVAC FRMVALYSIP KHRCVNLFLS AYIEKWLKSE KVDEDLLISE VTVASEGRMQ
     RLREDVEEVD EQCPPDPLSQ LVQCFQRAAT SERKQLVPIV DDNLYIQYVR VMASSIHIND
     DEQNNAEDDA ISMEAQELEK QQLLHEQSRL ADRGVAVMVL MYLSACNGEP NVMVEKTLAL
     GIHILNGGNS DVQNIMLNYL QEKKDVRFFS SISGLMNRCS VLNLEIFERQ LKAEGLGMGA
     ELSVGKHQNL NDSEFICSLF RFIQLTCEGH NSEFQNYLRN QPGNTTSINL IICTVDYLLR
     LQESIMDFYW HFSSKEVVDE AGKAHFLKAL SVCSQVFNTL TESIQGPCVG NQMALANSRL
     WDAINGFFFL FAHMMDKLSK NHTQLELLRE FLSLQKDMIV LMLSMLEGNI LNGSIGKQMV
     DTLAESQQNV QLILKFFDMF LKLKDLTTSQ AFQEFDTNKD GWISPKEFLR AMEAQKMYST
     EEINYLMMCT DVNNDGKIDY MEFTERFHNP AKDIGFNLAI LLTNLKEHIT GDSRLDQILQ
     TASSMCEYFD PYLGRIEIMG SNKRVEKVYF EIKEEWLEQF NKPQIKQSKK DFLFNVLQDD
     GGEQGKLEAF VNFCEDTIFE MSHAAEISSE DRDSRIERAK KQREIFTGMA DKTDTISAFD
     IILKIMKKMG TSIVSFCRYL RPSELRQLKH SAALHFSSMT YGQLILIFLK IVLFIFVTIF
     RGAFYLINTF FRFILLMMYG VWEEEKASSK LTAENAVHHT LPKDFNIVPQ LYEPEKPEVY
     EAFGIQLTQG IGEGLSMKNP NNQPQFEKSF SMHIGNSSPF SFASAESASV QNERQLMIYS
     NQIPDTYTPA AVSVCNDDSN IVVKEIYEPK IAETTSSAKG SAFNFLARNF YLLKYITLAL
     AFCINAILLF YRVADNPSND EKVVLEADNS KLQNEEHMEN GIEEELAIHD NYYYLAHMLI
     FLSVAHCAAS LALLIAYYQL KVPLIIFKRE KLVARKLEFE GMWITEMPSE DAVSGKWDSM
     IISSPSFPEK YWDKFVKKKV KDKYKDQFDE EELNRLLGLD KTVVDSSNSS SSSGVDWCYQ
     IWKLGVIFTD GSFQYLLMYL FFSAVGIWNP FFYAGHLIDV VISFPMLQTI LKSVTHNGKQ
     LILTVMMVLV VVYLYTVLAF NFFRKFYVQE DDGEETDSKC NNMISCFVFN VYAGIRAGGG
     IGDELQSPYG DEREAWRILF DMTFHFFIII ILLAIMQGLI IDAFGDLRDQ QESAQDKLES
     NCFICDIGKD FFERLPHGFD HHTTKEHNLA YYLFFLMHLI NKDDTEYTGQ ETYVWELYEK
     RCWDFFPVGE CFLKQYEEQL MAS
//
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