ID A0A0V1DHC2_TRIBR Unreviewed; 761 AA.
AC A0A0V1DHC2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Glutamate receptor ionotropic, kainate 2 {ECO:0000313|EMBL:KRY60817.1};
GN Name=GRIK2 {ECO:0000313|EMBL:KRY60817.1};
GN ORFNames=T03_14510 {ECO:0000313|EMBL:KRY60817.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY60817.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY60817.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY60817.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY60817.1}.
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DR EMBL; JYDI01000004; KRY60817.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1DHC2; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF588; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE GLR-3; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRY60817.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 474..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 723..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 344..699
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 354..418
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 761 AA; 86436 MW; 124F638BA0ABE8B2 CRC64;
MVKFDDSSKP FLNSIDLYPP STAVGTVISN LIKQFQWQRA VILYQDNFAM EIFNSLKKIK
QNCIINYYLC KVVIHSLFSK TVLFNLKTCM LFFGLMQLQE LLNLQRKDYS VIFHAQRLNP
GRQFRPQLKQ LKELQHIYFF VVQADLVTVR KFLDDAMEMN MLGPYYHYVF TDLDVYTLDL
IPYKMKGCNI TAIRFVDDDA PVTKRIIARL KNHKATNGSW PIFTSGTLPT YVAVINDAVS
VITKTAIVLQ NSLKPESIDC RNESVWRGGT TFMNFLKATA FQGSTGHIQF DGYGKRFNFS
MQIVEATTQG FVKIAAWTQQ RGLEHVKSDL PKTAQIAESL ENKVLRVTVY MEAPFVMYKK
SVEKLSGNDR YEGFCIDLLE RIAEMNKFNF TIHEVKDKSY GTPDANGRWN GIIGELINGD
ADVAVASLTI NFVRSEVIDF SVPYMHLGIS ILFKKPEKTP PSLLSFLAPL SLDVWMYMGA
AYVVVSLILW LVARISPSEW VCSHTCQGEE ENKENQFSLG NSFWFTIGSL MQQGCDIAPR
AVGTRMVASV WWFFTLILIS SYTANLAAFL TVERMEYTIN SAEDLVKQTK IRYGTLNRVY
EKMWMAMKSS EPSVFVNGSR EGISRVKQGN YAYLMESSML EFYVERDCDL TQIGGLLDSK
GYGIGFRKGS PYREAISQTI LYLQEKTVIT ELKDKWWKRR GGGKCDSADG KSSISAELGL
QNVGGVFVVM LLGLGLAVGV TIFEKLKTYT RSRQSQKKDN N
//
