ID A0A0V1HCE9_9BILA Unreviewed; 948 AA.
AC A0A0V1HCE9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Very low-density lipoprotein receptor {ECO:0000313|EMBL:KRZ08122.1};
GN Name=VLDLR {ECO:0000313|EMBL:KRZ08122.1};
GN ORFNames=T11_7935 {ECO:0000313|EMBL:KRZ08122.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ08122.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ08122.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ08122.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ08122.1}.
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DR EMBL; JYDP01000091; KRZ08122.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1HCE9; -.
DR STRING; 268475.A0A0V1HCE9; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 8.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:KRZ08122.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRZ08122.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..948
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006879043"
FT TRANSMEM 839..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 321..362
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 365..404
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 368..404
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 405..444
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 408..444
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 541..583
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 584..626
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 627..671
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 727..778
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 809..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 36..54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 48..63
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 152..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 159..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 211..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 238..250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 245..263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 257..272
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 296..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 322..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 329..347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 948 AA; 105030 MW; E664EB649D115D8F CRC64;
MTMKSIFLYI CASIFISFHI SLATDKDCLN NGGFLCPSGR CISPSWLCDG EQDCEDNADE
QNCSDRTCRK GEFKCANSNK CIPQSWVCDS SIDCTDRSDE DPTICTKHHC PSDHFRCHLD
GKCIPLTWVC DSHPDCVDGS DELSNMCVKH PCNETEFSCK NERCIPKEWE CDRDDDCGDN
SDEHDKCSYH CDPKSFQCVE SGKCIPYEYV CDGQMDCSDR SDEMNCKQLT KLPEHHSCRA
HEFQCQDGAC INERFVCDGD VDCPDMSDEM NCLSNCSALH FRCASGKECI PSVYRCNGIA
DCGDGSDEKN CASESVGEVK HCSAKQFDCG NGFCIDWDVV CDGKQDCPGY KVVDEEPLLN
CSLKGTDFCK EKPCEQLCTN TPIGPQCSCR PGYTVSLTNP KQCNDINECN TAGKCSQICI
NTVGSYTCKC YDDYVLLNNK RSCRANGPQP KLLLTNRLSI RQFGLISLTP EMLVNNLNSV
VAIDYLYKKR LLFWSDISKE QIFSCQFGND FHAINASDCE RPIISNNVSS PDGLAVDWIH
DLIYWTDTGM DTISVATLDG KLRHTLIRDG LDEPRAIAID PSCGMMFWTD WGVSPKIESA
AMDGTNRFAI DRDVIWPNGL TLDMLEHRLY WVDAKLKQIC SSNYFGQDKK VILNSRNRIY
HPFSVSVFEE TLYWTDWNSE GVHMANKFTG ENNRPLLKGM FGLMTVKIFH PVAQPNCNTF
KPSRENKCEN SECAHLCVPS MKIAAGQTAP AKMITNTKPY VCLCSDGYGL QANARDCIAK
DAAATTVTID TLKKANPAAS AAAAAATTTV TTTGQGDGQG KTFTKQEHST TVKTSSSKAG
MVLALLFTLS TIVGAVSWFV WKQRPLNVHF GQFFCLSYPF CRRGQDHYDH LRLTLDNEEY
QSGTLISGTG SGIYQPTVKS NLGDMDAGTA LAESPMTPTV QNGGIPLA
//
