ID A0A0V1HE08_9BILA Unreviewed; 2729 AA.
AC A0A0V1HE08;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Unconventional myosin-XV {ECO:0000313|EMBL:KRZ08447.1};
GN Name=MYO15A {ECO:0000313|EMBL:KRZ08447.1};
GN ORFNames=T11_13293 {ECO:0000313|EMBL:KRZ08447.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ08447.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ08447.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ08447.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ08447.1}.
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DR EMBL; JYDP01000086; KRZ08447.1; -; Genomic_DNA.
DR STRING; 268475.A0A0V1HE08; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13201; FERM_C_MyoXV; 1.
DR CDD; cd00124; MYSc; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041795; MyoXV_FERM_C.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF26; MYTH4 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 111..794
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 957..1106
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 2085..2149
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2241..2396
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 2401..2720
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2409..2490
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 671..693
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1280..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2143..2191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2148..2164
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2165..2191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 204..211
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2729 AA; 312716 MW; 257C7ED8F6F6E143 CRC64;
MPQAGAGKFA NLFVHAAIAN GIEEDLAEVF GRLPARLTIP KCAAFDTCTR NGPNLTGDLV
WYKTKQGYAL PGKITEVDSA SSTAWVQSND KKEEIAEFQF TDLQKRASDA MSFEDLIQLD
DLCNPAVLWA LKTRFEYGKT YTYIGEMLIS INPYRHFDVY GPEIMEQYRK KMTTSLPSHV
YGFAEMVQRR LYAFDTSQWI IATGITGSGK TELCKLMVQY FAEGCGREMK EAAFNDKLYH
AMHILQSFLN AKTAANDNST RGGKIYSLQY QNKKLTGAKL AYCLLEKTRL VSHVRGERNF
HIFYEMIAGL KQQTRQSFGL NKPENFFYLN QGKCVNLGSR EENNFELLEN ALEIIKITLD
QRHYIFRLLS AILHLGNIYF EEQTEDSNRK LVIANQNEVQ WVAYLLQMDP DEITHRLTTK
VIESRDQKVV HALTLDRALD IRDAIAKELY MGLIRWIIMK INNQLCNNDN DCNEINILDL
YGFECFKVNS FEQLCINYIN ERIQRLFVRV QFCSEQMEYI REDIVWDRNV GANLLNNSIF
NILVKQPNGI LSLLDDECSF PKGSDESFLI KCQNNYDDSP LFTAKTKRQL GFVVQHFFGH
ARYNVVGFVD KNREVHSAQT VEFLLESQNI LIAQMFEKQK LALSKRSAEN ENFDTYRIRA
PTFAMQLHEE FNQLTKRIEK YMVHFVRCIN PNKTKEADVL DMQFVLEQIK CLGLTEVLHM
QKFGFTIKMK FRDFLVRYGC LKPETATVEG KDEKNMCLYI LTSLAHQYFQ DFRIGKTKVF
MKDIVAEHLD SILSERLSSS VIIIQKYCRG LLARRKFHHL YDWITHLQAI VRGSQARKKF
SLIKAKVAEE AQQYAKQSRN LEVFRELSIK PNSQDGNANL QQRNSCAIVS VNHLEMPQNL
SEMLLTKTNL DADKNIVRAD RRIASHHEQE FILPHDLHEY SFNKYAQQYF KNHTWQMRRD
PINTPFLHKD SEADMQLSLT LFRLILRYMN DTSLSSSQEI ILSNYIIQKG IDNKNLRDEI
YAQVINQIHG NPNQANAERG WRLLGLCVSA FPPTDAMFKY ALNYVMNADC DGFKNLLKTK
LLQSIHDNNT TVRRYPPCIL EHKAIRSKAK MALLSYLSDG NKVGSQIDSW TKAEEFAELA
LKNGGISECT GWTVSLECQD AVIRLNGNQY LLDVLSYIEL PQLFPAQKSD YLITMKQHKK
PHLEPSTIQE RLEALERRPN LRTLVSDDFH SSKLKKGGSI TSLVHRARLQ HGEKLDSASV
KQEWLNWNEK CAAQSKIRPD HLNLDHDGSV TNNARCQSRM SSNSYQTDHS ILTADTSNQT
RPPSSVNTLR SSKFCETSHP SVDENQRKTF SWSKTSTRQE APALANNLSS QAEQSENKQN
CQNYDKENVD KKNSIPAEQA AIQDIAYMSI NRRPISNYSS LSSHFRAISI PGRNSEVDEF
LDQLFNPVLG NMNDPKSLAA TIKGGGDESD NKNQPVAVEQ AQTMYSSVYS FMPQYASPVF
MMMPYDAARM FMPNQRDSQV QGMQQFSNVK AQGNFNADQA NVLMPVPLMP VSFGSYMQAN
SIGQEVFKGP SNMLPLSMIQ NSSPKAWTRL HEYQHPSPPN GVGSDVMYTS FNPHTVNPNS
TDEHCMHENN FNNDLSNKVK EEMTSLSEAG SFFPNSSQLW KGRDEMKSKN EDDSDQKLFY
QWEQISKSDA AAKCKPLSTP TKTLIKEETG SLLSRDSFAS RDIINRNNTK SVASLDASKE
HENIDNSNYS TLTTSESKIH QKESDNMKNY KTLSREHLYG NLTYDSENRW INPCENLYQT
EDAHCRSNTP TAYRLEQPQL TNAESFDTLT VSHRDASEFG YDSRVSMRDG LMKIPPSICS
TLTRESRIDS RPSFKTQDYF SSTLVGLKEK RRGPALTYGN VAWKLVIRKE LFFPNDSLQD
PAALDAVFYQ IVRDTFNEKD SFRLEKAERN QMIRLLTSNG IELETLTSAN ISPSFKKHVV
QIARSWPLYF CRLYPVTVSN KFGEDRPHYV GISESGIWLI DRQGEGNDET LRIVECYEFE
DIDHTEATEN EFLLSTVNGV IIRVSTKSAE EITNLANKYM FGPNQGKEYV RATADYITEE
PNLLSFRKGD IIQLVKTMPD AHPGSGWLYG KINTKYGFFP KEHLDPISDS EEEEDDDDDE
NVEQTSEVPN GLEASNQMTP TSPPPVSAHS TQDKLTMMEF AMLHFREAQK YESTQNSTLT
TLKRKSKKEW TWKDVADLVK FTKSPIQNPL LKLDKGDVCK LAVDCFLNLM MYMGDYPLKK
DTNYLDCVYK ITAACREHPI LRDEVYCQVI KQITNNKSSK PDSALMGWRM LSILTAYFDS
SDVFRPYLQK YLSDSASDNR RAYHGTAMEC FQNFRQTLQF GGRRFILSPQ ELESISQGKN
LKRQVYHLPG GTKKVINTKS VTVVEEIIKE LCIDLNVRSS LEQQEFSLCV VIESDNVMRI
LSNDEYILDI TSELEEMKRE YFLLLKRIVW MHPLRKDSEL YTDIMFFQVL PDYIEGLLVV
MRGPDSVSAA TMDDIATLGA LLACADDDWD GQMVTARDIV HLLPKTVHNI RHVTLELWTD
RINQKLRQLS PKTLPIVARA KFLDLLQTWP LFGSTFFYIP SVSDPRAKGE CLMALNRHGV
QFLDIHTHEV LFEFRLNEIL STQKSYPDGT TSMNQQSTVE HMDIKIGNML QQHVLTLRTD
QGAEISRLFG QYIYVDSQSR GLLGIEGKH
//
