ID A0A0V1HFR6_9BILA Unreviewed; 1963 AA.
AC A0A0V1HFR6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Voltage-dependent calcium channel unc-36 {ECO:0000313|EMBL:KRZ09624.1};
GN Name=unc-36 {ECO:0000313|EMBL:KRZ09624.1};
GN ORFNames=T11_9385 {ECO:0000313|EMBL:KRZ09624.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ09624.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ09624.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ09624.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DEF8 family.
CC {ECO:0000256|ARBA:ARBA00029450}.
CC -!- SIMILARITY: Belongs to the peptidase C48 family.
CC {ECO:0000256|ARBA:ARBA00005234}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ09624.1}.
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DR EMBL; JYDP01000070; KRZ09624.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd20819; C1_DEF8; 1.
DR Gene3D; 1.10.418.20; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.30.310.130; Ubiquitin-related; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR047983; DEF8_C1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR003653; Peptidase_C48_C.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF37; VOLTAGE-DEPENDENT CALCIUM CHANNEL UNC-36; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF02902; Peptidase_C48; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF13519; VWA_2; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50600; ULP_PROTEASE; 1.
DR PROSITE; PS50234; VWFA; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1963
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006879113"
FT DOMAIN 259..444
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1259..1311
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1737..1914
FT /note="Ubiquitin-like protease family profile"
FT /evidence="ECO:0000259|PROSITE:PS50600"
SQ SEQUENCE 1963 AA; 226498 MW; 68A94ADD11DBFAA0 CRC64;
MTETSSAGLL FQLFVLAAEL HAQDLRGRGA IPISASMCVL GVEQWAKSFG LDLYSTATTA
TQAEELEQKY QEKNARVEYF DPEEVIDVMK ARLEKFLGRR RQLAEILKEN LENSYSLFQM
VDREAINDLQ SDDFYRFVDS KSCLNRHYVD PLLINSSLSV NYIPNPNFFN LPVNTEKSAV
HVPTPVYARD PELLSEIIWT ESLDDIFKAR RAREFFAASW QYFCSQKGFM RFYPASPWFY
DDSHTCLDMY IDAATHAKNI IIMLDMSGSM LGQRFEIAKQ TIEMILETLT ENDFFNMIVF
SEEPKFILSC FRNRLVQATI KNKKLMRVTL DNVTAEGIAN YPAALSLAFE VLIEASQNPG
VNSGCQNAIM LITDGPSDTY EDIFEKYNKD KMIRFFTYLI GDDVTETREV RWMACYNRGY
FAHISNLADV QEKVQSYIGV MSRLTAERNR TDPVWTGAYY DRLGAVLVAT VAFPVVANDS
FRGVVGASAL ITELQQMAPL YMLGTHSYTF IVDNNGYVVH HPQLRPLYMG KAKPHYNSMD
IMEMEVLADN YLENGSLANP VDYDSDLRRH LADGVSSKDF LRKFSQKIIW ACDGSNNLRR
VYLQNNVYYY RGINNTLMSL ALAVPEDSRY RIALPSTYSP YPFKNIDCKT VKWFSGTNWR
LHPDWHYCRI NDSDYSMTKE EAFVINMRHY SETGRIARNC ALYTYLIERL LFDAEVTSQM
DSAWIQESRL DERKGVHLVY LATHAGLTRF VSMDLKDVQY QPDVQTWQSD DNRTEELPVT
LDKPYFHFSK RHTRALDEVF YKRAMQFLNG EFVFDVNITN NIYLKNGSQT YPHAKDGRSI
IVTGNRAILV RDDYGNEAPA SVVGFEMLYA SFEEMIYNAS HKMCHFNSKV RCYLLDEHGY
IVYASLPHTS QERVHYLRQF FGHLSLENTE NGAIERYLMK KLVDLFVYQK LLYVDFQDLC
QNLNLYNSAR RLFNPLLTVS KLIISMLQKM IRFFLEINPL GIIFSLFSRY TTTFRDIQDG
LPCDRASSFY LLNNDFRGPL TLAEGKQLCS SVATSDSYAR VSSCNLYAYA VRIEKTNLVL
VVYSTEGTQC NGDLCKDYFS RDSLPWGFSI ALNATDKVMH PQACKLTTRY RRPPSACQAM
EDDDPFAHCS GCSSQATLLL VLLCVAVLFL MQPEVDSVPS AEVVPSDRFW ATMLTTLSGV
SVEELTSAIA KCKDLVLQTA PMSAIRRELV RRLIELRQKL HELKDGLTQD SKFDATVMGH
QFKTPSRTIL ERRYCECCGG LIWAFLQPWY FCRLCGFYVH VKCVKSVKRQ CASLTVNENP
VFELEICPER GLAMQNFQCA DCKTEVSIDS SLMVEASQTA RLCHYSGSYF CSVCHWNDEM
VIPARVIHNW DFTKYTVSRC SRQFLRLMQK RPILRLEAMN SCLFKNIPQL QKIKTLRARL
LLMKPYVMYC REAASQCLMT HLRPYAHFME ALDVYSIRDL IDINETVLES RLMQALEIFE
KHIKNECSIC QGNGYVCELC DNSEILFPFD RSVGKCGQCS WIYHKSCFDK NNGICPRCLR
MSSRMAIRLL SKDSNTRTSS DKCSLSLHFI SSHSMCFVEL DLHPRYSSLD LLSAIDCLYR
VLYLEKREES RRRMGIWLSL QSKNEDQITN ESTFLFSLMT KIAGDFGAVE LVGEDKKLNF
MISKRLLSKI ECYPDVVEAA LQASPTRQQQ RQRVDGRNQT TETGQRLAIR YNDVDCITLY
EEHLTCLLFD NWLNDEVVDF FMVLLLELLN DYKNYDFCFL PASFLESIKR GRDHCVLRRL
NVFEKKFIVI PVCHNYHWTL VILCYMNNMA AALNGRVDAD CSPFILYVDS LHWSINKRIL
VELRHSFSRE LGIRLNVPDI KLGDNELPYK IVRVPKQKNL SDCGVYLLHY TECFIRYAVQ
KSFNVHQFLE ESLKFFELSS GASKRENLKN TILVLARHFK RPA
//
