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Database: UniProt
Entry: A0A0V1HUF5_9BILA
LinkDB: A0A0V1HUF5_9BILA
Original site: A0A0V1HUF5_9BILA 
ID   A0A0V1HUF5_9BILA        Unreviewed;      5060 AA.
AC   A0A0V1HUF5;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   22-NOV-2017, entry version 13.
DE   SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:KRZ14376.1};
GN   Name=Rya-r44F {ECO:0000313|EMBL:KRZ14376.1};
GN   ORFNames=T11_17485 {ECO:0000313|EMBL:KRZ14376.1};
OS   Trichinella zimbabwensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ14376.1, ECO:0000313|Proteomes:UP000055024};
RN   [1] {ECO:0000313|EMBL:KRZ14376.1, ECO:0000313|Proteomes:UP000055024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ14376.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRZ14376.1}.
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DR   EMBL; JYDP01000025; KRZ14376.1; -; Genomic_DNA.
DR   Proteomes; UP000055024; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000055024};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KRZ14376.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4419   4437       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4610   4629       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4670   4696       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4813   4835       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4858   4880       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4939   4958       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      242    296       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      302    371       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      611    846       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1041   1222       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4161   4196       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4199   4231       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4174   4185       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4209   4220       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5060 AA;  576681 MW;  83AEAADD2FD94245 CRC64;
     MTDFQENSTG EQDDISFLRT GDVVCLTCLA PCKESGTGSA ERVSLAAEGF GNRICYLENV
     SDKNKPPDNA TSMFYIDQAL SVRALQEMMS SESPNISGSS STHRTLLYGH AVQLKHTLSG
     MYLTCLSTSS ASDKLAFDVG LCETNVGESC WWTIHPASKQ RSEGEKVRFG DDVILVSVAT
     ERYLHMSSTN GNTVLAAFHQ TLWSITPNSS GGVRERHMAI LQCCMESKES LVICYLSISL
     KVCYVCGNDV LRLNHGNDEC LTIPENWSDS PQNNIVIYEN GKSCNQARSL WRPELIHGKW
     QSSLIGWEQA FRIRHITSGR FLALNEDNQD VKRSTFEEKE EEGMGVATVK YGETVIFLQH
     LQSNLWLSCQ LELLTFLKSS SNTKFEDEIV DLLCIFKTTA VTKKNMGKVE EKKAIAVEEA
     RMDDCFILFK AQEEESQSAR VIRKCSQILN RFLRGLEGLQ MEGRDSLAWN RADLSETVKL
     MEDLIQYFAQ PEENVDFESM QNGLRALRNR QDLFQEEGLL NMIIDTIDQF SVVESMTELL
     DVTKEDKCKD WQDISTYLYL LVAAMIKGNH SNCTQFASAQ RLNWLFSRLS NPQSAEGILD
     VLYCILTESP EALNMINEDH VKAVISLLEK VGHDPKVLNV LSALCEGNGV AVRNSQNVIC
     SELLCNKKFL LQTKMIDQVS SVMANIFVGS YENSAMYPRW YFEAELEYME SMHTSGQKPH
     LRIGWASSAG YRAYPGSGKK WGCNGVGDDM FSFGFDGQYI YAGIAALKLS KLIGGIEKFV
     GTHEFRKGDV IGCSLDLAVP EIQFSLNGHQ IGTSVRNFSS CDCLFFPVMS LSAIVSCRFF
     FGGSQGKLRF GPKKGYLPIS EAAITPVKLI SCISFGDNRK GYFAGPSTVI SDYIVFQPKP
     IDTKDRRSET QKTHPCLTSY ERLPTAERSY NLNLAKETLK TIVALGYRID LGKASNRVKT
     FRLGQNFLMS NGYKPAPLDT REYELNETLE TLVDQLAKNM HNIWAQSKIQ RGWTYSNNEV
     RNVNIKTTSH LVAYDFLDPN IKAANRDKAG QIIRSLLVYN YCIEPPTAEQ DEGAVKQAQV
     MNLQKRTYRF EKSYAVKSGK WYFEFEVRTS GFMNVGWMDV SASPDSDFGL HKSSYAYDGY
     LGRKWRGESE SYGKKWNVGD VVGCFLDLTD RTICFSLNGE LLLDSSGTEV AFDNVSAEDG
     FVPAFSLAPG QIGRLNCGQN VNTLKYYTTC GLQEGYEPFC IRMSRQAPMW IAKCEAEFDE
     INEKEKRFKV TRIPQSGDNP PCLKLQCKSA GMLERCSLAL FRLNLPVFCK EANDNRVCNQ
     YFTETLSERN AGKRNCETDR TAESGRRGKM KGVRGSRNQD EDISFHDQQN YAEQYEVSNH
     AVMKSNYLVQ KTFSLDDDSS EVTENRFRKA PRLRSSASEA NLKEKESIDS QDKISASYAV
     NARKLQEACA SKSKIRSDEN DKFLSGRLSS RKLDDRVADV DSTESLDMPK SGPGRRPTVI
     RLESDSKVKK RSNYFSSGHD LLVEASKLSA PSGNQHVSIG TSVSFYSTPD DYYFGIRVFP
     GQDLANIWIG WLTPQFSFIG SQIAADSQRI CFLESTHGTL DNIQEFRSCY IVNGMELLTA
     AGGSSNVSKM AGLLAGCLIN TATGELKFHV NGKQTEMSYR VEPGTILYPA VFVLPTSREV
     LQFELGNIEK TLPIASAQLN ERSNAVQLMC PPRLKIEICK TRTWLRVPDQ CARVTSLKLS
     DTRGWSVLCD DLVRTMMLYV PERDSSIDIL ELVEHESLCT FHQQTLRLYC SLCAQGNFKI
     AHILCQHVDE DQLMYAIQSK YLSGSLRRCF YDVLIAIHLK CHYDARLAES HEYIIPLNAK
     LKDRNYFNYE TKSVYPHALN SDITLKSSIN VMEVKKKIST EDEKFLMSPT FDFHTLKQYV
     VDALEEATLE ALMNSRDLIG GTNTTHFLPI LKLFDTLLLV GVLSDTDIHR FFRLLNPRSF
     QETLDSPQNV KGLVDLDLDE MVQLELCHIM NHLCDLQLQG RVESLINFAE TFVGETQNDQ
     LRRYLEIKQT DMPSAEAARK TKEFRCPPKE QMLKLLDFKA DRDEQTDEEG ELEVSAMSEF
     LQRVLREFHC NMVKCIGNSD KNDDNYSANV EQKQLESENM NWVEKLAWMV VPVPPALLSE
     DERIKFDGEE AFRNIILSTL IKWTGNKAID DPNLIREIFG LLLRQYTRIS EVKSALKTAY
     CIHERSTEDV QSFLDNLCQI RRLLCVQFEA TEEEVLKNSL WDMMNNKVFF QHPDLMRLLK
     VHENVMTIMV NVLSRAQKSE LDDRRNRSTQ DDIKKAFQSS ISDLVVACCK FLCFICRSST
     KNQAAMFEHL PFLLDNATML LAKPSLRGSV PLDVAYYSFM ENSELALALK EDDLEKVAFY
     LSRCGLQANA EMVFKGYPDI GWDPVEGERY VDFLRFCVWV NGECVEENAN LVIRLLIRRP
     ECLGPALKGQ GEGLFRAFKD AISLSSEISN LHKGRDLRSR FNFDLSHYPN PEIEEEDYID
     LGAAILGFYS SLADLLGKCA PDHLTVKSGK GESVRLRSIL RSLTSVEDLE AILALRFLLP
     NVFAAKEESV RSSCIGLLPC HKQSILLFLE RVYGLIDKEM VFRLLEQSFI LDFRAATILD
     HPAYAESDLA LALNRYLCGS VLPLLTSHAH CFADAEHYYS LLEATLHTVY RMSKIKSLTK
     SQRSAITEFL LAFTKEIHPG MMKKLLQKVV VDISSLNEFA TVPLQIMTQH YECFSKHYGI
     SLHEDMASEE QKRLSMLLFT TIFDSLGKRA FDSDLFASAL PCLTAIGSAL SPDYAMQSYA
     EEDIQNMNVS SDHMEVWRPH PVDASNVQLS VNLQNLVQRF AQHFHDSWAS RKLEKGWRND
     DIYSRTNCTH PRLKPFGMLK EFEQNFYKER CSECLKALLA WGYSIDQETQ VSSVQPKSMN
     PTSNVRSASV FCPQPIDLSN MTLSEEMCEL AERMAENSHL IWVSKTIEDL NDANTGIMVL
     LVPWDILADS EKRKHRFRAQ EVLKFLQYQG FRLKSPLHRD KEEHQQTVVD SNTHRPVEKR
     FACNLLEKLL AYLENAAQKM DVIKPSKQFS RYRNYTLPSE DVKFFGKVLL PLLESYFRSH
     RNYFTAASSA SLSGVASIKE KEMVAGLFHR LMSVFRTKHN AFGCHVKSTV RCLQVLLQAI
     DFRSLVKINS DTLRTCAQIF LTNMVSDLMN ITKEIKNNGR YAEIKGKTLP CTSSLLFLYE
     AMLPLLTTLF CHLSKHGHGQ DFLVNDIQVG CYKIADCLYM LAAPITISRK SVKEEMEKHR
     SSIGQCLSAF ACCFPVAFLE ADFNANSRCS TVDRQHLLSE SKDASSSLLL NIPSLDNLLS
     NIEQLSNTNG KYQDAPAIFD VDIPMLCSYM SFWWQHGPTN NTQEKKLSAV SSDHINRLFS
     ACSRLICDHI GIAHADWICH LAPFITPMIN YVTIEPVRDY LLPMAEKVRM QADLAFKEEE
     KHRMHPDVFD ESTVIELHSI LIRDVYALYP ILIKFTDLHR ARWLKNPCWE TNALFEHVAF
     VFKLWITSQH MKREELNFIT QFESDFMTGT SRKTGKAAVA FRKKKRREGK RREKDSGSIV
     IACLKRLLPV GLSVFGGREL DLLQKVKEKY MKKENDERIK EYIFSSLAVP DQEDVFDKSH
     WQRKLYQQIG KAQMLGIDSM SQEMVVDKII FMGVTLCNLH NVEHPQTFQA DAWRKIVSSQ
     RKRAVVACFR MVALYSIPKH RCVNLFLSGY IEKWLKSEKV DEDLLISDVT VASEGRIQRL
     REDVEEVDEQ CPPDPLSQLV QCFQRAATSE RKQLVPIVDD NLYIKYVRVM ASSIHINEEE
     ENNTEDDAIS MEAQELEKQQ LLHEQSRLAD RGVAVMVLMY LSACNGEPNV MVEKTLALGI
     HILNGGNSEV QNIMLNYLQE KKDVRFFSSI SGLMNRCSVL NLEIFERQLK AEGLGMGAEL
     SVGKHQNLND SEFICSLFRF IQLTCEGHNS EFQNYLRNQP GNTTSINLII CTVDYLLRLQ
     ESIMDFYWHF SSKEIVDEAG KAHFLKALSV CSQVFNTLTE SIQGPCVGNQ MALANSRLWD
     AINGFFFLFA HMMDKLSKNH TQLELLREFL SLQKDMIVLM LSMLEGNILN GSIGKQMVDT
     LAESQQNVQL ILKFFDMFLK LKDLTTSQAF QEFDTNKDGW ISPKEFLRAM EAQKMYSTEE
     INYLMMCTDV NNDGKIDYME FTERFHNPAK DIGFNLAILL TNLKEHITGD SRLDQILQTA
     SSMCEYFDPY LGRIEIMGSN KRVEKVYFEI KEEWLEQFNK PQIKQSKKDF LFNVLQDDGG
     EQGKLEAFVN FCEDTIFEMS HAAEISSEDR DSRIERAKKQ REIFTGMTDK TDTISMFDII
     LKIMKKMGAS IVSFCRYLRP SELRKLKHSA VSHFSSMTYG QLMLIFLKIV FFIFVTIFRG
     AFYLMNTFFR FILLMMYGVR EEEKASSKLT AENAVHHTLP KDFNIAPQLY EPEKQEVYEA
     FGIQLTQGIG EGLCLKSPSN HPQLEKSFSL HIGNSPPYSI GPVESASVQN ERQLMIYSNQ
     IPESYTPAAV NVCNDDSNIV AKEIYEPKIA ETTSSAKGSA FNFLARNFYL LKYITLALAF
     CINAILLFYR VADNTSNDEK VVLEATNSKL QNDEHMENVI EEELAIHDNY YYLAHMLIFL
     SVAHCAASLA LLIAYYQLKV PLIIFKREKL VARKLEFEGM WITEMPSEDA VSGKWDSMII
     SSPSFPEKYW DKFVKKKVKD KYKDQFDEEE LNRLLGLDKT VVDGSNSSSS GVDWCYQIWK
     LGVIFTDGSF QYLLMYLFFS AVGIWNPFFY AGHLIDVVIS FPMLQTILKS VTHNGKQLIL
     TVMMVLVVVY LYTVLAFNFF RKFYVQDDDG EETDSKCNNM ISCFVFNVYA GIRAGGGIGD
     ELQSPYGDER EAWRILFDMT FHFFIIIILL AIMQGLIIDA FGDLRDQQES AQDKLESNCF
     ICDIGKDFFE RLPHGFDHHT TKEHNLAYYL FFLMHLINKD DTEYTGQETY VWELYEKRCW
     DFFPVGECFL KQYEEQLMAA
//
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