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Database: UniProt
Entry: A0A0V1HV04_9BILA
LinkDB: A0A0V1HV04_9BILA
Original site: A0A0V1HV04_9BILA 
ID   A0A0V1HV04_9BILA        Unreviewed;      5064 AA.
AC   A0A0V1HV04;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   25-OCT-2017, entry version 12.
DE   SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:KRZ14377.1};
GN   Name=Rya-r44F {ECO:0000313|EMBL:KRZ14377.1};
GN   ORFNames=T11_17485 {ECO:0000313|EMBL:KRZ14377.1};
OS   Trichinella zimbabwensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ14377.1, ECO:0000313|Proteomes:UP000055024};
RN   [1] {ECO:0000313|EMBL:KRZ14377.1, ECO:0000313|Proteomes:UP000055024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ14377.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRZ14377.1}.
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DR   EMBL; JYDP01000025; KRZ14377.1; -; Genomic_DNA.
DR   Proteomes; UP000055024; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000055024};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KRZ14377.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4423   4441       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4614   4633       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4674   4700       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4817   4839       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4862   4884       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4943   4962       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    347       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      587    822       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1017   1198       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4165   4200       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4203   4235       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4178   4189       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4213   4224       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5064 AA;  577360 MW;  2435133635A19293 CRC64;
     MTDFQENSTG EQDDISFLRT GDVVCLTCLA PCKESGTGSA ERVSLAAEGF GNRICYLENV
     SDKNKPPDNA TSMFYIDQAL SVRALQEMMS SESPNISGSS STHRTLLYGH AVQLKHTLSG
     MYLTCLSTSS ASDKLAFDVG LCETNVGESC WWTIHPASKQ RSEGEKVRFG DDVILVSVAT
     ERYLHMSSTN GNTVLAAFHQ TLWSITPNSS GGVRERHMGY VCGNDVLRLN HGNDECLTIP
     ENWSDSPQNN IVIYENGKSC NQARSLWRPE LIHGKWQSSL IGWEQAFRIR HITSGRFLAL
     NEDNQDVKRS TFEEKEEEGM GVATVKYGET VIFLQHLQSN LWLSCQLELL TFLKSSSNTK
     FEDEIVDLLC IFKTTAVTKK NMGKVEEKKA IAVEEARMDD CFILFKAQEE ESQSARVIRK
     CSQILNRFLR GLEGLQMEGR DSLAWNRADL SETVKLMEDL IQYFAQPEEN VDFESMQNGL
     RALRNRQDLF QEEGLLNMII DTIDQFSVVE SMTELLDVTK EDKCKDWQDI STYLYLLVAA
     MIKGNHSNCT QFASAQRLNW LFSRLSNPQS AEGILDVLYC ILTESPEALN MINEDHVKAV
     ISLLEKVGHD PKVLNVLSAL CEGNGVAVRN SQNVICSELL CNKKFLLQTK MIDQVSSVMA
     NIFVGSYENS AMYPRWYFEA ELEYMESMHT SGQKPHLRIG WASSAGYRAY PGSGKKWGCN
     GVGDDMFSFG FDGQYIYAGI AALKLSKLIG GIEKFVGTHE FRKGDVIGCS LDLAVPEIQF
     SLNGHQIGTS VRNFSSCDCL FFPVMSLSAI VSCRFFFGGS QGKLRFGPKK GYLPISEAAI
     TPVKLISCIS FGDNRKGYFA GPSTVISDYI VFQPKPIDTK DRRSETQKTH PCLTSYERLP
     TAERSYNLNL AKETLKTIVA LGYRIDLGKA SNRVKTFRLG QNFLMSNGYK PAPLDTREYE
     LNETLETLVD QLAKNMHNIW AQSKIQRGWT YSNNEVRNVN IKTTSHLVAY DFLDPNIKAA
     NRDKAGQIIR SLLVYNYCIE PPTAEQDEGA VKQAQVMNLQ KRTYRFEKSY AVKSGKWYFE
     FEVRTSGFMN VGWMDVSASP DSDFGLHKSS YAYDGYLGRK WRGESESYGK KWNVGDVVGC
     FLDLTDRTIC FSLNGELLLD SSGTEVAFDN VSAEDGFVPA FSLAPGQIGR LNCGQNVNTL
     KYYTTCGLQE GYEPFCIRMS RQAPMWIAKC EAEFDEINEK EKRFKVTRIP QSGDNPPCLK
     LQCKSAGMLE RCSLALFRLN LPVFCKEAND NRVCNQYFTE TLSERNAGKR NCETDRTAES
     GRRGKMKGVR GSRNQDEDIS FHDQQNYAEQ YEVSNHAVMK SNYLVQKTFS LDDDSSEVTE
     NRFRKAPRLR SSASEANLKE KESIDSQDKI SASYAVSNTK RNLRPFKVLL VNIMKLLLIK
     REFLDARKLQ EACASKSKIR SDENDKFLSG RLSSRKLDDR VADVDSTESL DMPKSGPGRR
     PTVIRLESDS KVKKRSNYFS SGHDLLVEAS KLSAPSGNQH VSIGTSVSFY STPDDYYFGI
     RVFPGQDLAN IWIGWLTPQF SFIGSQIAAD SQRICFLEST HGTLDNIQEF RSCYIVNGME
     LLTAAGGSSN VSKMAGLLAG CLINTATGEL KFHVNGKQTE MSYRVEPGTI LYPAVFVLPT
     SREVLQFELG NIEKTLPIAS AQLNERSNAV QLMCPPRLKI EICKTRTWLR VPDQCARVTS
     LKLSDTRGWS VLCDDLVRTM MLYVPERDSS IDILELVEHE SLCTFHQQTL RLYCSLCAQG
     NFKIAHILCQ HVDEDQLMYA IQSKYLSGSL RRCFYDVLIA IHLKCHYDAR LAESHEYIIP
     LNAKLKDRNY FNYETKSVYP HALNSDITLK SSINVMEVKK KISTEDEKFL MSPTFDFHTL
     KQYVVDALEE ATLEALMNSR DLIGGTNTTH FLPILKLFDT LLLVGVLSDT DIHRFFRLLN
     PRSFQETLDS PQNVKGLVDL DLDEMVQLEL CHIMNHLCDL QLQGRVESLI NFAETFVGET
     QNDQLRRYLE IKQTDMPSAE AARKTKEFRC PPKEQMLKLL DFKADRDEQT DEEGELEVSA
     MSEFLQRVLR EFHCNMVKCI GNSDKNDDNY SANVEQKQLE SENMNWVEKL AWMVVPVPPA
     LLSEDERIKF DGEEAFRNII LSTLIKWTGN KAIDDPNLIR EIFGLLLRQY TRISEVKSAL
     KTAYCIHERS TEDVQSFLDN LCQIRRLLCV QFEATEEEVL KNSLWDMMNN KVFFQHPDLM
     RLLKVHENVM TIMVNVLSRA QKSELDDRRN RSTQDDIKKA FQSSISDLVV ACCKFLCFIC
     RSSTKNQAAM FEHLPFLLDN ATMLLAKPSL RGSVPLDVAY YSFMENSELA LALKEDDLEK
     VAFYLSRCGL QANAEMVFKG YPDIGWDPVE GERYVDFLRF CVWVNGECVE ENANLVIRLL
     IRRPECLGPA LKGQGEGLFR AFKDAISLSS EISNLHKGRD LRSRFNFDLS HYPNPEIEEE
     DYIDLGAAIL GFYSSLADLL GKCAPDHLTV KSGKGESVRL RSILRSLTSV EDLEAILALR
     FLLPNVFAAK EESVRSSCIG LLPCHKQSIL LFLERVYGLI DKEMVFRLLE QSFILDFRAA
     TILDHPAYAE SDLALALNRY LCGSVLPLLT SHAHCFADAE HYYSLLEATL HTVYRMSKIK
     SLTKSQRSAI TEFLLAFTKE IHPGMMKKLL QKVVVDISSL NEFATVPLQI MTQHYECFSK
     HYGISLHEDM ASEEQKRLSM LLFTTIFDSL GKRAFDSDLF ASALPCLTAI GSALSPDYAM
     QSYAEEDIQN MNVSSDHMEV WRPHPVDASN VQLSVNLQNL VQRFAQHFHD SWASRKLEKG
     WRNDDIYSRT NCTHPRLKPF GMLKEFEQNF YKERCSECLK ALLAWGYSID QETQVSSVQP
     KSMNPTSNVR SASVFCPQPI DLSNMTLSEE MCELAERMAE NSHLIWVSKT IEDLNDANTG
     IMVLLVPWDI LADSEKRKHR FRAQEVLKFL QYQGFRLKSP LHRDKEEHQQ TVVDSNTHRP
     VEKRFACNLL EKLLAYLENA AQKMDVIKPS KQFSRYRNYT LPSEDVKFFG KVLLPLLESY
     FRSHRNYFTA ASSASLSGVA SIKEKEMVAG LFHRLMSVFR TKHNAFGCHV KSTVRCLQVL
     LQAIDFRSLV KINSDTLRTC AQIFLTNMVS DLMNITKEIK NNGRYAEIKG KTLPCTSSLL
     FLYEAMLPLL TTLFCHLSKH GHGQDFLVND IQVGCYKIAD CLYMLAAPIT ISRKSVKEEM
     EKHRSSIGQC LSAFACCFPV AFLEADFNAN SRCSTVDRQH LLSESKDASS SLLLNIPSLD
     NLLSNIEQLS NTNGKYQDAP AIFDVDIPML CSYMSFWWQH GPTNNTQEKK LSAVSSDHIN
     RLFSACSRLI CDHIGIAHAD WICHLAPFIT PMINYVTIEP VRDYLLPMAE KVRMQADLAF
     KEEEKHRMHP DVFDESTVIE LHSILIRDVY ALYPILIKFT DLHRARWLKN PCWETNALFE
     HVAFVFKLWI TSQHMKREEL NFITQFESDF MTGTSRKTGK AAVAFRKKKR REGKRREKDS
     GSIVIACLKR LLPVGLSVFG GRELDLLQKV KEKYMKKEND ERIKEYIFSS LAVPDQEDVF
     DKSHWQRKLY QQIGKAQMLG IDSMSQEMVV DKIIFMGVTL CNLHNVEHPQ TFQADAWRKI
     VSSQRKRAVV ACFRMVALYS IPKHRCVNLF LSGYIEKWLK SEKVDEDLLI SDVTVASEGR
     IQRLREDVEE VDEQCPPDPL SQLVQCFQRA ATSERKQLVP IVDDNLYIKY VRVMASSIHI
     NEEEENNTED DAISMEAQEL EKQQLLHEQS RLADRGVAVM VLMYLSACNG EPNVMVEKTL
     ALGIHILNGG NSEVQNIMLN YLQEKKDVRF FSSISGLMNR CSVLNLEIFE RQLKAEGLGM
     GAELSVGKHQ NLNDSEFICS LFRFIQLTCE GHNSEFQNYL RNQPGNTTSI NLIICTVDYL
     LRLQESIMDF YWHFSSKEIV DEAGKAHFLK ALSVCSQVFN TLTESIQGPC VGNQMALANS
     RLWDAINGFF FLFAHMMDKL SKNHTQLELL REFLSLQKDM IVLMLSMLEG NILNGSIGKQ
     MVDTLAESQQ NVQLILKFFD MFLKLKDLTT SQAFQEFDTN KDGWISPKEF LRAMEAQKMY
     STEEINYLMM CTDVNNDGKI DYMEFTERFH NPAKDIGFNL AILLTNLKEH ITGDSRLDQI
     LQTASSMCEY FDPYLGRIEI MGSNKRVEKV YFEIKEEWLE QFNKPQIKQS KKDFLFNVLQ
     DDGGEQGKLE AFVNFCEDTI FEMSHAAEIS SEDRDSRIER AKKQREIFTG MTDKTDTISM
     FDIILKIMKK MGASIVSFCR YLRPSELRKL KHSAVSHFSS MTYGQLMLIF LKIVFFIFVT
     IFRGAFYLMN TFFRFILLMM YGVREEEKAS SKLTAENAVH HTLPKDFNIA PQLYEPEKQE
     VYEAFGIQLT QGIGEGLCLK SPSNHPQLEK SFSLHIGNSP PYSIGPVESA SVQNERQLMI
     YSNQIPESYT PAAVNVCNDD SNIVAKEIYE PKIAETTSSA KGSAFNFLAR NFYLLKYITL
     ALAFCINAIL LFYRVADNTS NDEKVVLEAT NSKLQNDEHM ENVIEEELAI HDNYYYLAHM
     LIFLSVAHCA ASLALLIAYY QLKVPLIIFK REKLVARKLE FEGMWITEMP SEDAVSGKWD
     SMIISSPSFP EKYWDKFVKK KVKDKYKDQF DEEELNRLLG LDKTVVDGSN SSSSGVDWCY
     QIWKLGVIFT DGSFQYLLMY LFFSAVGIWN PFFYAGHLID VVISFPMLQT ILKSVTHNGK
     QLILTVMMVL VVVYLYTVLA FNFFRKFYVQ DDDGEETDSK CNNMISCFVF NVYAGIRAGG
     GIGDELQSPY GDEREAWRIL FDMTFHFFII IILLAIMQGL IIDAFGDLRD QQESAQDKLE
     SNCFICDIGK DFFERLPHGF DHHTTKEHNL AYYLFFLMHL INKDDTEYTG QETYVWELYE
     KRCWDFFPVG ECFLKQYEEQ LMAA
//
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