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Database: UniProt
Entry: A0A0V1HV52_9BILA
LinkDB: A0A0V1HV52_9BILA
Original site: A0A0V1HV52_9BILA 
ID   A0A0V1HV52_9BILA        Unreviewed;      5054 AA.
AC   A0A0V1HV52;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   25-OCT-2017, entry version 12.
DE   SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:KRZ14374.1};
GN   Name=Rya-r44F {ECO:0000313|EMBL:KRZ14374.1};
GN   ORFNames=T11_17485 {ECO:0000313|EMBL:KRZ14374.1};
OS   Trichinella zimbabwensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ14374.1, ECO:0000313|Proteomes:UP000055024};
RN   [1] {ECO:0000313|EMBL:KRZ14374.1, ECO:0000313|Proteomes:UP000055024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ14374.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRZ14374.1}.
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DR   EMBL; JYDP01000025; KRZ14374.1; -; Genomic_DNA.
DR   Proteomes; UP000055024; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000055024};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KRZ14374.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4408   4429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4604   4623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4664   4690       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4807   4829       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4852   4874       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4933   4952       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    347       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      587    822       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1017   1198       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4155   4190       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4193   4225       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4168   4179       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4203   4214       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5054 AA;  576303 MW;  F61995CA1A1BD8E5 CRC64;
     MTDFQENSTG EQDDISFLRT GDVVCLTCLA PCKESGTGSA ERVSLAAEGF GNRICYLENV
     SDKNKPPDNA TSMFYIDQAL SVRALQEMMS SESPNISGSS STHRTLLYGH AVQLKHTLSG
     MYLTCLSTSS ASDKLAFDVG LCETNVGESC WWTIHPASKQ RSEGEKVRFG DDVILVSVAT
     ERYLHMSSTN GNTVLAAFHQ TLWSITPNSS GGVRERHMGY VCGNDVLRLN HGNDECLTIP
     ENWSDSPQNN IVIYENGKSC NQARSLWRPE LIHGKWQSSL IGWEQAFRIR HITSGRFLAL
     NEDNQDVKRS TFEEKEEEGM GVATVKYGET VIFLQHLQSN LWLSCQLELL TFLKSSSNTK
     FEDEIVDLLC IFKTTAVTKK NMGKVEEKKA IAVEEARMDD CFILFKAQEE ESQSARVIRK
     CSQILNRFLR GLEGLQMEGR DSLAWNRADL SETVKLMEDL IQYFAQPEEN VDFESMQNGL
     RALRNRQDLF QEEGLLNMII DTIDQFSVVE SMTELLDVTK EDKCKDWQDI STYLYLLVAA
     MIKGNHSNCT QFASAQRLNW LFSRLSNPQS AEGILDVLYC ILTESPEALN MINEDHVKAV
     ISLLEKVGHD PKVLNVLSAL CEGNGVAVRN SQNVICSELL CNKKFLLQTK MIDQVSSVMA
     NIFVGSYENS AMYPRWYFEA ELEYMESMHT SGQKPHLRIG WASSAGYRAY PGSGKKWGCN
     GVGDDMFSFG FDGQYIYAGI AALKLSKLIG GIEKFVGTHE FRKGDVIGCS LDLAVPEIQF
     SLNGHQIGTS VRNFSSCDCL FFPVMSLSAI VSCRFFFGGS QGKLRFGPKK GYLPISEAAI
     TPVKLISCIS FGDNRKGYFA GPSTVISDYI VFQPKPIDTK DRRSETQKTH PCLTSYERLP
     TAERSYNLNL AKETLKTIVA LGYRIDLGKA SNRVKTFRLG QNFLMSNGYK PAPLDTREYE
     LNETLETLVD QLAKNMHNIW AQSKIQRGWT YSNNEVRNVN IKTTSHLVAY DFLDPNIKAA
     NRDKAGQIIR SLLVYNYCIE PPTAEQDEGA VKQAQVMNLQ KRTYRFEKSY AVKSGKWYFE
     FEVRTSGFMN VGWMDVSASP DSDFGLHKSS YAYDGYLGRK WRGESESYGK KWNVGDVVGC
     FLDLTDRTIC FSLNGELLLD SSGTEVAFDN VSAEDGFVPA FSLAPGQIGR LNCGQNVNTL
     KYYTTCGLQE GYEPFCIRMS RQAPMWIAKC EAEFDEINEK EKRFKVTRIP QSGDNPPCLK
     LQCKSAGMLE RCSLALFRLN LPVFCKEAND NRVCNQYFTE TLSERNAGKR NCETDRTAES
     GRRGKMKGVR GSRNQDEDIS FHDQQNYAEQ YEVSNHAVMK SNYLVQKTFS LDDDSSEVTE
     NRFRKAPRLR SSASEANLKE KESIDSQDKI SASYAVNARK LQEACASKSK IRSDENDKFL
     SGRLSSRKLD DRVADVDSTE SLDMPKSGPG RRPTVIRLES DSKVKKRSNY FSSGHDLLVE
     ASKLSAPSGN QHVSIGTSVS FYSTPDDYYF GIRVFPGQDL ANIWIGWLTP QFSFIGSQIA
     ADSQRICFLE STHGTLDNIQ EFRSCYIVNG MELLTAAGGS SNVSKMAGLL AGCLINTATG
     ELKFHVNGKQ TEMSYRVEPG TILYPAVFVL PTSREVLQFE LGNIEKTLPI ASAQLNERSN
     AVQLMCPPRL KIEICKTRTW LRVPDQCARV TSLKLSDTRG WSVLCDDLVR TMMLYVPERD
     SSIDILELVE HESLCTFHQQ TLRLYCSLCA QGNFKIAHIL CQHVDEDQLM YAIQSKYLSG
     SLRRCFYDVL IAIHLKCHYD ARLAESHEYI IPLNAKLKDR NYFNYETKSV YPHALNSDIT
     LKSSINVMEV KKKISTEDEK FLMSPTFDFH TLKQYVVDAL EEATLEALMN SRDLIGGTNT
     THFLPILKLF DTLLLVGVLS DTDIHRFFRL LNPRSFQETL DSPQNVKGLV DLDLDEMVQL
     ELCHIMNHLC DLQLQGRVES LINFAETFVG ETQNDQLRRY LEIKQTDMPS AEAARKTKEF
     RCPPKEQMLK LLDFKADRDE QTDEEGELEV SAMSEFLQRV LREFHCNMVK CIGNSDKNDD
     NYSANVEQKQ LESENMNWVE KLAWMVVPVP PALLSEDERI KFDGEEAFRN IILSTLIKWT
     GNKAIDDPNL IREIFGLLLR QYTRISEVKS ALKTAYCIHE RSTEDVQSFL DNLCQIRRLL
     CVQFEATEEE VLKNSLWDMM NNKVFFQHPD LMRLLKVHEN VMTIMVNVLS RAQKSELDDR
     RNRSTQDDIK KAFQSSISDL VVACCKFLCF ICRSSTKNQA AMFEHLPFLL DNATMLLAKP
     SLRGSVPLDV AYYSFMENSE LALALKEDDL EKVAFYLSRC GLQANAEMVF KGYPDIGWDP
     VEGERYVDFL RFCVWVNGEC VEENANLVIR LLIRRPECLG PALKGQGEGL FRAFKDAISL
     SSEISNLHKG RDLRSRFNFD LSHYPNPEIE EEDYIDLGAA ILGFYSSLAD LLGKCAPDHL
     TVKSGKGESV RLRSILRSLT SVEDLEAILA LRFLLPNVFA AKEESVRSSC IGLLPCHKQS
     ILLFLERVYG LIDKEMVFRL LEQSFILDFR AATILDHPAY AESDLALALN RYLCGSVLPL
     LTSHAHCFAD AEHYYSLLEA TLHTVYRMSK IKSLTKSQRS AITEFLLAFT KEIHPGMMKK
     LLQKVVVDIS SLNEFATVPL QIMTQHYECF SKHYGISLHE DMASEEQKRL SMLLFTTIFD
     SLGKRAFDSD LFASALPCLT AIGSALSPDY AMQSYAEEDI QNMNVSSDHM EVWRPHPVDA
     SNVQLSVNLQ NLVQRFAQHF HDSWASRKLE KGWRNDDIYS RTNCTHPRLK PFGMLKEFEQ
     NFYKERCSEC LKALLAWGYS IDQETQVSSV QPKSMNPTSN VRSASVFCPQ PIDLSNMTLS
     EEMCELAERM AENSHLIWVS KTIEDLNDAN TGIMVLLVPW DILADSEKRK HRFRAQEVLK
     FLQYQGFRLK SPLHRDKEEH QQTVVDSNTH RPVEKRFACN LLEKLLAYLE NAAQKMDVIK
     PSKQFSRYRN YTLPSEDVKF FGKVLLPLLE SYFRSHRNYF TAASSASLSG VASIKEKEMV
     AGLFHRLMSV FRTKHNAFGC HVKSTVRCLQ VLLQAIDFRS LVKINSDTLR TCAQIFLTNM
     VSDLMNITKE IKNNGRYAEI KGKTLPCTSS LLFLYEAMLP LLTTLFCHLS KHGHGQDFLV
     NDIQVGCYKI ADCLYMLAAP ITISRKSVKE EMEKHRSSIG QCLSAFACCF PVAFLEADFN
     ANSRCSTVDR QHLLSESKDA SSSLLLNIPS LDNLLSNIEQ LSNTNGKYQD APAIFDVDIP
     MLCSYMSFWW QHGPTNNTQE LIKFIFVCIM MLYEIYFRKK LSAVSSDHIN RLFSACSRLI
     CDHIGIAHAD WICHLAPFIT PMINYVTIEP VRDYLLPMAE KVRMQADLAF KEEEKHRMHP
     DVFDESTVIE LHSILIRDVY ALYPILIKFT DLHRARWLKN PCWETNALFE HVAFVFKLWI
     TSQHMKREEL NFITQFESDF MTGTSRKTGK AAVAFRKKKR REGKRREKDS GSIVIACLKR
     LLPVGLSVFG GRELDLLQKV KEKYMKKEND ERIKEYIFSS LAVPDQEDVF DKSHWQRKLY
     QQIGKAQMLG IDSMSQEMVV DKIIFMGVTL CNLHNVEHPQ TFQADAWRKI VSSQRKRAVV
     ACFRMVALYS IPKHRCVNLF LSGYIEKWLK SEKVDEDLLI SDVTVASEGR IQRLREDVEE
     VDEQCPPDPL SQLVQCFQRA ATSERKQLVP IVDDNLYIKY VRVMASSIHI NEEEENNTED
     DAISMEAQEL EKQQLLHEQS RLADRGVAVM VLMYLSACNG EPNVMVEKTL ALGIHILNGG
     NSEVQNIMLN YLQEKKDVRF FSSISGLMNR CSVLNLEIFE RQLKAEGLGM GAELSVGKHQ
     NLNDSEFICS LFRFIQLTCE GHNSEFQNYL RNQPGNTTSI NLIICTVDYL LRLQESIMDF
     YWHFSSKEIV DEAGKAHFLK ALSVCSQVFN TLTESIQGPC VGNQMALANS RLWDAINGFF
     FLFAHMMDKL SKNHTQLELL REFLSLQKDM IVLMLSMLEG NILNGSIGKQ MVDTLAESQQ
     NVQLILKFFD MFLKLKDLTT SQAFQEFDTN KDGWISPKEF LRAMEAQKMY STEEINYLMM
     CTDVNNDGKI DYMEFTERFH NPAKDIGFNL AILLTNLKEH ITGDSRLDQI LQTASSMCEY
     FDPYLGRIEI MGSNKRVEKV YFEIKEEWLE QFNKPQIKQS KKDFLFNVLQ DDGGEQGKLE
     AFVNFCEDTI FEMSHAAEIS SEDRDSRIER AKKQREIFTG MTDKTDTISM FDIILKIMKK
     MGASIVSFCR YLRPSELRKL KHSAVSHFSS MTYGQLMLIF LKIVFFIFVT IFRGAFYLMN
     TFFRFILLMM YGVREEEKAS SKLTAENAVH HTLPKDFNIA PQLYEPEKQE VYEAFGIQLT
     QGIGEGLCLK SPSNHPQLEK SFSLHIGNSP PYSIGPVESA SVQNERQLMI YSNQIPESYT
     PAAVNVCNDD SNIVAKEIYE PKIAETTSSA KGSAFNFLAR NFYLLKYITL ALAFCINAIL
     LFYRVADNTS NDEKVVLEAT NSKLQNDEHM ENVIEEELAI HDNYYYLAHM LIFLSVAHCA
     ASLALLIAYY QLKVPLIIFK REKLVARKLE FEGMWITEMP SEDAVSGKWD SMIISSPSFP
     EKYWDKFVKK KVKDKYKDQF DEEELNRLLG LDKTVVDGSN SSSSGVDWCY QIWKLGVIFT
     DGSFQYLLMY LFFSAVGIWN PFFYAGHLID VVISFPMLQT ILKSVTHNGK QLILTVMMVL
     VVVYLYTVLA FNFFRKFYVQ DDDGEETDSK CNNMISCFVF NVYAGIRAGG GIGDELQSPY
     GDEREAWRIL FDMTFHFFII IILLAIMQGL IIDAFGDLRD QQESAQDKLE SNCFICDIGK
     DFFERLPHGF DHHTTKEHNL AYYLFFLMHL INKDDTEYTG QETYVWELYE KRCWDFFPVG
     ECFLKQYEEQ LMAA
//
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