ID A0A0V1HWG8_9BILA Unreviewed; 891 AA.
AC A0A0V1HWG8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Elongation factor 2 {ECO:0000313|EMBL:KRZ15022.1};
GN Name=eef-2 {ECO:0000313|EMBL:KRZ15022.1};
GN ORFNames=T11_17562 {ECO:0000313|EMBL:KRZ15022.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ15022.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ15022.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ15022.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ15022.1}.
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DR EMBL; JYDP01000020; KRZ15022.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1HWG8; -.
DR STRING; 268475.A0A0V1HWG8; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR CDD; cd03700; EF2_snRNP_like_II; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF10; ELONGATION FACTOR 2; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:KRZ15022.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024}.
FT DOMAIN 17..267
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 600..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 99921 MW; E4D08B62CDD749B4 CRC64;
MVHFTVDEIR ALMDRKKNVR NMSVIAHVDH GKSTLTDSLV SKAGIIAAQK AGEMRFTDTR
KDEQERCITI KSTAVSMYFE LSQRDLVYVR GENQIDYDEK GGSKVPFPGF LINLIDSPGH
VDFSSEVTAA LRVTDGALVV VDCVSGVCVQ TETVLRQAIG ERIKPVLFMN KMDRALLELQ
LDQEELYQTF QRIVENTNVI IATYGEETGP MGNIMVDPAL GSVGFGSGLH GWAFTLKQFA
EMYAEKFGIQ AEKLMKNLWG DRYFNPKTKK WTSTSSEGSK RGFNQFVLDP IFKVFDAVMN
MKKEETATLL EKLNVKLPAD ERDLEGKPLL KAIMRRWLPA GETMLQMICI HLPSPVTAQK
YRIELLYEGP QDDEAAVAMK NCDVNGPLMM YISKMVPTSD KGRFYAFGRV FSGKVMTGMK
ARIQGPNYVP GKKEDLYEKA IQRTVLMMGR YVEPIEDVPS GNICGLVGVD QYLIKSGTIT
NFKDAHNMRV MKFSVSPVVR VAVEPQNPAD LPKLVEGLKR LAKSDPMVQC VFEESGEHIV
AGAGELHLEI CLKDLEEDHA CIPLKKSDPV VSYRETVVDI SNQMCLSKSP NKHNRIYMKA
QPMPDGLPED IDKGEVNPRD DVKTRGRLLA ERYGYDVNEA RKIWCFGPDG NGPNILVDCT
KGVQYLNEIK DSVVAGFQWA TKEGVLCEEN MRGVRFDIHD VTLHADAIHR GGGQIIPTAR
RVLYASALTA SPRLLEPVYL VEIQCPETAV GGIYGVLNRR RGHVFEENQV SGTPMFIVKA
YLPVNESFGF TADLRSNTGG QAFPQCVFDH WQVLPGDPFD SNSRPYHVVA ETRKRKGLKE
GIPDLSNYLD KMDGFRLAFL ILDGTNEAND KAVKFRCFLR WLEEFHRITV E
//
