ID A0A0V1I208_9BILA Unreviewed; 5498 AA.
AC A0A0V1I208;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Twitchin {ECO:0000313|EMBL:KRZ16455.1};
GN Name=unc-22 {ECO:0000313|EMBL:KRZ16455.1};
GN ORFNames=T11_433 {ECO:0000313|EMBL:KRZ16455.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ16455.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ16455.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ16455.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ16455.1}.
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DR EMBL; JYDP01000011; KRZ16455.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR CDD; cd00063; FN3; 28.
DR CDD; cd00096; Ig; 3.
DR CDD; cd05748; Ig_Titin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 54.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR PANTHER; PTHR14340:SF9; TITIN; 1.
DR Pfam; PF00041; fn3; 27.
DR Pfam; PF07679; I-set; 25.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 27.
DR SMART; SM00409; IG; 26.
DR SMART; SM00408; IGc2; 21.
DR SUPFAM; SSF49265; Fibronectin type III; 16.
DR SUPFAM; SSF48726; Immunoglobulin; 26.
DR PROSITE; PS50853; FN3; 28.
DR PROSITE; PS50835; IG_LIKE; 20.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 7..99
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 110..204
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 216..311
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 323..414
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 442..531
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 683..795
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 844..930
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 935..1014
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1028..1119
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1313..1406
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1410..1502
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1507..1603
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1609..1702
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1702..1798
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1806..1899
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1902..1999
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1998..2092
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2100..2193
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2202..2296
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2300..2391
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2397..2493
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2499..2594
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2694..2787
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2793..2887
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2891..2980
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2988..3080
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3086..3180
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3281..3374
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3380..3474
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3478..3562
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3572..3666
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3672..3767
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3771..3858
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3865..3959
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3965..4061
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4067..4162
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4265..4359
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4365..4460
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4464..4554
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4561..4657
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4663..4758
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4761..4858
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4863..4946
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5052..5147
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5153..5247
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5254..5342
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5347..5438
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5445..5498
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 422..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2177..2206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2868..2893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..838
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2177..2199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5498 AA; 610020 MW; C33459523D6FD46B CRC64;
MPGGKAPRFT QKPVIKQTPE GHLLMECLLD SQPNPKVQWF HGSKPVTDNA RYTLNSKHLG
KEQYLVTLLI KDPTADDRGT YKCNVANEFG DSNANINLNF AAEEESKIKP PVFLTKPKII
PKNDGAIILM ECRVKSTVLP TATWIHNGAP VQAGGRVKIT AVKEPDHTYL FELELHDLVP
EDSGLYKCTV KNDAGETNAN LTLNFDIPPE PADFSPTIAE KPSITTSADG SVVSLKCVAK
AKPKPKVTWS LNGVPLKESA KLVHHEENAG LNLYLFRLDI MNPTEKSAGI YKCSLKNKLG
ETSANVNLKI DAEDVKQKLE KKPIFLPRIE PTVDAERIFI ECKFQSDTSP KAIWKKDNKI
LSQSEQITKK LTSNGKGQYT ASLSVKNPTD RDSGKYELFL ENSSGKAETS FPIVVPEMKR
LSPSVKAKSP SPVPKKKSSA KPPIFTNELH NESVEEGATA ILAVTLECDT STKLIWSRNG
LQISTGGNFE TFFDGSAGRL TIRNVKKQFG GTYVCTAESR FGNAKSSCRL TVESKGKSND
SIPTIEMQMD DDQSQAKTSI ATDYSEDEMT ESISELPSVS MKPPQISRRH TEADAELFAQ
PHVGRGARRS SLRPGEIAEE TFRRSSNARE PSNEKHGHRR SSDWSYLERR ASSVEITSES
VQELLEKPTG PLMPLPENTP APPKITEIPE NVTVLEVCCL SNIIKINIIS IKHSLLGETA
LVSCSVQGNP VPTFRWMKAG REVLPGGRYK HLTHTDNNTV TLVIGKAKLE DEDAYDLIAE
NEHGTDQATI KVFVTNAAGV DFRSLLKHRQ YEKWGKHKHK GDSGDLKPGD DQQRRASMLP
DKKPSFWEIE IQDQRVQQTV HKEAKFECKF CRPKAKIRWY KQKQEIFTGM KYKIINDKEF
CTLIINNPDQ DDASKYTCVA NGIPTTAMLY VEDPPTKFTF EKPLPTTTEL IRTREGILEC
RVSHPDAPVK WYKGDDELKP SSKYSMEIDR FGRCVLVIAN VDYDDMGEYT AKINKDNVTS
CCVAVGNPRC EFISPMKSQK VQEKENASLE CELNDKAAEV TWYHDESKIT IDKVKFEEVR
IGRKRKLVIK NCGVEDEGVY KCMTSDDQTM GQLIVEPLNK FLEKLTDKTV VEKDDITLQC
QTKDTHGAAT WFKNGKQITP MPGGKFETKS KNGTHTLLIR KCELTDDDKY EVEVGGLKGE
CSVSVLEAEK KPIFTGKPQK IEAEAGKPIT VSIPYIVKGT RKADPVATLS HNGTALKLKT
GDKINVTVTA DTVEIEFKDA KMADDGKWDV TLSNTAGSTT TNFQMEVRDR PGPPEGPLEI
ADLKATECKV KWRPPKDTGN SPIHHYLVEM LDGTTGEWRK LGQSKACEMK VPNLIKGQSY
KFNIVAVNKI GVSDPLIGGE FIAKDPDCKP TLDKVALKNL KVKVGEVIKY KIDIGGEPPP
TAIWLFGEQP VKQNIRAKVV TTAKETELTV SDAERGDSGK YTLRVKNSLG EETGVGLVIV
VSKPAKPTGP LVVSEVNKEG CKVAWNAPED DGGEPIEEFI VEAQESGKGG DFFEVARCGP
AEKEAVIKGL KNKGKYNFRV KAKNKEGFSD PLVTKEATLI KDPWDEPGKP GKPEVTDSDK
DYVSLSWTAP TSDGGAPIEK YVVECKEKNS KEWKPVGESA KTTATINQGL KEGNEYQFRV
IAVNKAGPGE PSQPSSIHVM KPKFTAPWID LKSLGNLVIK AGQEAKFSPK IGGQPPPQVT
WTKVGSGQIN EGSRIHFKDS KPGLAVLTIL KAVRGDCGDY MINVKNQKGE QSATASLTVL
DRPTPPKGPL KVTDVFENEM TLHWQMPEDD GGVPVEAYEV EKFDVDHGRW IPCGRTNEEN
LTVHNLVPGH SYLFRVKAVN KEGESDALSL TDPVLAKNPY DPPTKMEKPN VTDWDSDHVD
LEWKPPENDG GAEIEKYIVE KKRKNDKWVP AVEVSPDKLE ARIGDLTKDE QYQFRIIAVN
KAGPSEPSEP SNRVIAKPRF LAPLINREDL PMTTVKVGQL IKFNVRIIGE PAPEVFWEKD
GKKLSSSAEL TIENPDYLSK FFINKSARKH AGIYKITAQN SSGVDVAEVT ISVLGKPSKP
KGPLEVNDIF ADHMTLSWNA PEDDGGTPIE CYEIEKCDPA TGIWIPCGRT ADTNFVADGL
LEGNSYEFRV KAVNSEGESE PLQTDTSIKA KNPYSYETNP DKPNKPEVVD WDIDHVDLAW
SPPQNDGGAP IEEYVIEKRT KYGRWEPAAS VPGDATNVTI SDLTPNDEYE FRIKAKNKGG
FSDPSDPSEA VITKHRNLPP KIDRSAMQPV TVKAGQVIRF DVPVEGEPPP TMTWFHESEM
LKPKGKIKIE NGDYNTKFAI RLAERSDSGV YTLKAVNVNG EDEATVIVEV TDKPSAPEGP
LEAKEVYGDH ITLGWKAPED DGGIPISHYI VEMLDPQLGH WVVAGKTPTG DSTEYTVENL
IPGHDYKFRV KAQNANGESD ALETTRPITA KNPYDEPGKP GQPQVNDWDE NFIEIGWTPP
ESDGGAPIES YIVEIKEKFS PFWSKAGETP ADVTAFKVTD LTPGNEYQLR VRAKNKAGPG
EPSDETERVV TKARRVPPKF NKEIIQDIRL KAGQHYRLEI PLIGEPAPQL SYAFNDSPID
VSDRLKFEQR EHDVLFVIKR ALRTDTGFYL ITAKNEYGED TARLNVTVLD HPSKINDLKV
SDIRKDGCKI SWQAPEDDGG SEISHYVIEK EDIATGRWVT AAETPSCEAD ISGLHPNHEY
RIRVKAVNRN GESEPVVCDE SFIARDPFEE PDKMLPPVVL DWDKDHVQLE LIKPESDGGA
PIEKYVVEMK CNNGEWMPAV EVPADQNLVT VPGLKEGQKY QFRVKAVNKA GSGQPSDPSK
TVTAKPRHLP PKIDRSTLHS VKIKAGQKLE FDVNVEGEPP PQIRWLLNGE SLGSSERTRV
VNKDYNTTLR TVDVKRFDSG VYKIIAENES GTDEAEVMVT ILDAPTAPRG PLQVSDVHSE
GCNLAWKPPE DNGGSDILNY VIEKQEDGGR WVECGTSYDT EFKVGKLKPG EEYNFRVKAV
NRQGESKPLT TSTSIVAKNP YDTPDQPENL KVIDWDKDHM DLQWQPPVND GGAPIEKYLV
EVKSRLDDWK PAVEVSADTC KATVPGLTPR ESYQFRVRAV NKAGPGKPSE ETAPMIAKPR
RLAPKLKLDD LFDIRIKAGQ PLSIVVPFEA EPQPLIIWMH EDIKLESNDR MEIEHVENLT
SVEIPRSVRS DTGPYTIILQ NEYGEDKGVV NVTVLDVPLA PEGPLKVKDV TKQSCNLSWK
PPNDNGGSEI IHYVVEKMDT SRGTWQEVGE FPDCEAKVNR LIPGKEYKFR VKAVNSLGES
KPLTTEASII AKDPFDVPSP PEELTVVDWD RDYVALQWKP PENDGGSPVS EYIIDVREKG
NPYWCEAGRT GGNKSSFCVK NLKEGATYEF RVTAVNDAGP SNPCDTVCAA AKPRRLSPKI
LTTIRLIKVR AGMPLRMPVD FIGEPAPDVS WTKEKASLNE RIQVENAEGK TELFISSAKR
TDTGPYNLRL TNEYGQDQGE FQFLIQDVPG VPEGPLEAVE ITKDSVVLTW KPPLDDGGSE
VTNYVVEKRD THSDVWNLVS SFVPGTTVKA LKLTEGHSYE FRVMAENAFG RSEPLNTIRP
ITAKDPFAPP DKPGVPVIKA HDRDFIAIEW QKPMDDGGSP ITHYDIERRH NKTGRWIKIN
QDPVKTLKFQ DNRVNEGHLY EYRVVAVNEA GPSEPSDPSS SVYAKPMFEV PKFLLDLNGK
EVRIKAGEPL DLNIPFTGSP TPNIEWIKDK ISVPESSLNT DDQHTQLYIA HSKRSDSGDY
KVVAKNQSGT AEALVKVVVI DKPSEPRGPF NYTGISKHSI KLEWNPPDDD GGSEIIGYAM
EIQEFGSPVW EKIRDYIPST SYTVKGLDEG RQYLFRVRAE NMIGLGEPLH SVPMTAKPSY
DVPGAPSAPE VTGYDNTYVS LKWNPPRSDG GSPITEYIVE KHEKKGGGDW SPCYTSHSTS
CECIVKNLVP GESYQFRVRA VNLAGEGPPS RFSEPCTCQP FIHPPGPPDS PRVGKVTKRS
VDLTWNRPLK DGGSAITGYM IEKKPFVSNE WIPCNTQPIL GTEFTVTGLP EGEQFMFRVI
AVNKAGPGEP SKPTENIIIQ DELGKPYIDI GSVKDVTVRA GEPYTIQIPY TGGNPKPTVS
FLNNDAEIFD EENRVKITVT DDCAILENLC SKRSDTGPYK VSLSNRYGKD SCKFKVKVLD
RPSPPVGPLE ATNVDADAIT LHWLPPKDDG GEEIRNYIVE KKEPNSDEWK TVNASVMGTS
FRVRNLKEGS QYEFRVKAEN QYGISDPLTT MEPVVAKSQH QPPSAPGIPE ACGTSEDFVN
LTWTKPFYDG GQPITGYIVE KREKGEENWI RADFGMFPDT KAKITSVIPN KCYEFRVCAV
NSVGAGPFSQ TSLPIYSQYP PSAPKIDISL LTRDIYTVVG NPLSINVSYS AVPNGTVTWT
KGSEILLPND HLNVEQNENI AVVSTKSCVR SDSGIYTVVV QNSLGSDSAT IRVTVFDRPS
PPMGPIIHSD ITPESCVLSW LSPKDDGGSP VTNYVIEKCT TDQPDNWERV SSFVRGLRYE
VIGLVPKASY KFRIRAQNEY GTSDPLESDL PIITKYQFDV PSPPGEPEAV DMDTTWVTLT
WDRPNSDGGS KILGYLVEFR EPDSYKWTSA NAFLAKEPRL VIESLRDQSE YQFRVLAKNA
AGFSKPSEPS SFIKLKPKFS PPGAPSLPYT DRIGRNYVTL MWEPPLLDGG SKITGYIVER
REVGSYSWIR CNDYNVRDPE FTVPDLVEFR DYEFRVSAVN SAGRGAPSPV ATVKVQESGG
FKPEFVRKLF NTVVPLNRRA VFECEAIGKP TPVVRWIRHG RDISDCGRYK VEESETKYTL
TIEEVWDIDN GEFACEATNQ FGSDVTVAVL KIQEPPVIDK EPGNQTYSEE ELARIKIFFR
GDPEFSCSLS QNGREISADD DFVKLVAFDD HVLITLNSVR KQDAGRYEFT VQNESGKATC
VFYVYVTGLP GPPSGPLLIT DITQHSAMLH WKPPREDGGT KILYYLVEKR DLAREEWTTV
ANSVKELSVQ AIGLFEKHEY SFRVSAVNEN GQGPPLDVDQ PITAKFPFDP PLAPGIPDVI
SVTNDYVSLS WDRPKRDGGD AVAGYVIEKK EEGTELWQRC NAVLIPQTVF NVPNLIDGRK
YLFRVFAVNA AGMSPPAECA SAVTFSPNSS AKAPEIVTPL RNVSGEEGRS VRLECEITGD
PAPEIRWFKG ARDITNGGKH SIFSIGNKHV LVINDLFGED ADEYSCRALN IAGCRSTTGE
VFIKSAPKIF LPPLYQARIE FRKGETVSLK IPFRGYPQPT ALWTKQGSRC TSEGRFSIET
VDRLATLNIS NSSKEDSGIY ELRVENEIGF DVSSVEIRIC DRPDPPQYLS VETVLDNAVI
LSWKPPVDDG GSEISNYLVE KRQLPNSDWI PCVKSRQC
//
