ID A0A0V1KPS1_9BILA Unreviewed; 1882 AA.
AC A0A0V1KPS1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=CLIP-associating protein 1-B {ECO:0000313|EMBL:KRZ49264.1};
GN Name=clasp1b {ECO:0000313|EMBL:KRZ49264.1};
GN ORFNames=T02_12579 {ECO:0000313|EMBL:KRZ49264.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ49264.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ49264.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ49264.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ49264.1}.
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DR EMBL; JYDW01000323; KRZ49264.1; -; Genomic_DNA.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005819; C:spindle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:UniProt.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00788; KU70; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 4.10.970.10; Ku70, bridge and pillars; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR006165; Ku70.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
DR InterPro; IPR047087; KU70_core_dom.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR NCBIfam; TIGR00578; ku70; 1.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF9; CLIP-ASSOCIATING PROTEIN; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM00559; Ku78; 1.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 162..199
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1327..1530
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 646..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1882 AA; 210171 MW; 8649ED6B2B75807D CRC64;
MGNFSELLNK NSTDPKTRVE LGQQLLDLIQ REGVPNDANN LTLFMDVMVQ WLNGTNFKVA
LLALEILSLS LEVSGATVSH IVLENASTIM ERLGDNREQV RQDAVGLLLK LMNTPGCTPQ
GVLDRIVEGF SHKQWLVRIG VMIVLQQILR SYGPSCLQLG KLVPSICRLL ADPMNQVRDV
ATETLVEMYV FLGDKLAMDI QRKQLVPNAR AAALFSRFED VKRNGLVGSS CSSNGTVGNA
LDSVADFTDA TPTAHRQISS VSTLKKPLLT AVKQSEVSNF TGKRATSAPP VKRLQTTSRY
AGNAGAVDED SFYAAFEDVP KVEIYSAKEL SIQLQQIRTI VMNTNGDWEK RVDSLKRLRS
LLISGASQYD EFFVELRSLE VPMQIAGKDL RSQVVREVCI TVAYLAERLG PKFDHFAEII
LPLLISLIQN SAKVVSTSGL ISCRFIIKNT HAPRIVPVIT GSLESKSKEI RRCCCDFIAM
MCRQWSSHEL EKNVGALQGA IRKGLSDADP EARAFSRKAY WSFSDHFRDQ AEMLFQSLDP
GKQRQLLGEI SQSSSSHSLY NDLRTSQESV KCSTASQYGA SRAGGTIPCL RSASEIDTGA
VRRAVAMKQA NAGKAFLGVA SSSNMNSLPR PMKMLLSTSG NYPKFGRFGA PNPSTATTAT
STRLESTPRS PTSTSNKSVS QPGSRSSSPT ARSSLTNSAR RARPIANITG FRSQTSSRDS
SPSRTPRRLS TPDRSYYSFG RFFCTPARDA DCANVVGVSR GRKLDDVSSE SSPCFFGERS
FRGSECSENS SSMMDVLRSC SSTVWIERKE GLLCLQSFFR SGGRLTAGEL KKACDLFARL
FVDPHHKMFT VFLDTVIEFL QAHGSDIQDW LFVLLCRLLS KQSNELLPSV QSKLLKTMDV
VRAVFPVEAQ FQALTRYLVD PTQTPNVKMK LNVLNYLNAL IYSMQSSHLT DTADMRMAIS
RIVQWTGEPK STEVRRTAQA TLLALFSLNT AMFTQILSSF SKAYQDTVSR ILHTHVRHFP
DLSTLCIHDS AEQSSKVIER NSDVQDSLRR TSEEIMRYPF SSDCKTTGSN GSTVMDSVDN
YFKNGSAGQG GRLELLSNGV NTDEERQEEI IGQILTELSN HNARNVERKK ALSTLKHVSR
DGSFTLWEEN FKTILLILLE TLGDDDPDIR AAALPVLKEI CTRQPQRFQD YAELTILKLL
DAHKDPERKV TRAAEDCATV LALHLAPLVC LRVLTPVILN DQGPALLAAI KMTTKVIEQM
DTDELLRILK ELVPGIIMGF ENPTDSSVRK ASVLCLVAVH KKVGFEVLEP FLEPLNSSKP
IWAGRKCIIF LVDCDSAMFT EAACTAFQES ITAIRDIYCH NSVTGERDYL ATVLYNTKKA
ENSHRFNGIS VLHNLSLPSV EKVKQLERLC NGPPFNYFDE NYGTGQSNID EVFWLSAMMY
NECKVQNQKR TIFLFTNNDS PHHGDIELRK RGRKKIKDLK DKNVTVEVVA VGTTNFVLDN
FYKVALADEH ACHDDNLTLA NRADDLFSRI VKKTRNRRGF ATLNFSLGPG IDISVTLYNN
ISTANLPPSV MLDGRTNGEV KLISNLFDPE TGEKLHRFNL VKYQEYGRRR IAMTEKELEE
MSSFTSPGLV LLGFQPLNRL KVYHHLRPAF FISPNENIIK GSTVLLNALM RKCSDKEMTM
ICRLTARKNT SPRLVALVAE IEESEEAAQS TKCRRFHGIY LPYEDDLRDL QAVIASAPKI
QVDNQLVDLW KKVIKRMQIQ YTVGTIQNPV LQKHYRTLEA VVLDREKIGH FDDQTMNLKW
IDNEAGMLLE QIKEHLNFDD QKKSSSSYTD VEFDLEAEAR NGLLGKRTVV QLRNALRSKG
VVIASNTRKP DIIKRILDLY AL
//
