ID A0A0V1KYW9_9BILA Unreviewed; 2632 AA.
AC A0A0V1KYW9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ATR {ECO:0000313|EMBL:KRZ52472.1};
GN ORFNames=T02_15812 {ECO:0000313|EMBL:KRZ52472.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ52472.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ52472.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ52472.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ52472.1}.
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DR EMBL; JYDW01000192; KRZ52472.1; -; Genomic_DNA.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRZ52472.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1609..2173
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2290..2602
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2600..2632
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ52472.1"
SQ SEQUENCE 2632 AA; 300451 MW; FC0BD67ECB7E3E2E CRC64;
LRSKVAFVED SYAMNEKMEQ DGKDDIEVFG EHLNRLLSIY NVEGQKVNRS HTYHLCYLLH
FELLPSRVLK DIQNTGDGSY YKTEMRFFTK LIRERPAVLT NYSKDAEIAT TFYSWTLMKT
LGVFSVYGSV ALKEEIMEMA RIIFNALGQR YSVSVMERLI VEFCKIQYIR SQALNKAGTK
MTYTFQLGLR SMEVESVGEQ YPTFHMTDLE FEIADNDQCE IFQCFFCDFI TQRESILISV
QSNWLECFLI TILDQFEDGD FDLKERSLTC LLNIICNEKT VFPPHLGPFF IDHCFAFIEW
LAEYWPSSFV NAEHVCTLLV EVLQFCTAYA NGHQRPVGCS ILFQKITSKM LSQFCERLKR
IIVNANFASF DAKLRIRLLE MFTYCLSNLR LFPPVDEEIA NRLGCCFEAA LDSLISRTLL
AEPLEMLLSH LFYFCDLVWT SESTSCFIFE YYQKMLDEIT KGFAEPATVI EALSTCNFLL
RVLFHVEEEQ MSSKFRQALD IFKCEICDRL FSMQDGFAVV VPNLNGLNPD IAASMFQLLI
DTITLILLAF VNKMKVHHVT FATALLSLPW IDTEDLLDSK CADVEQFSSM KLIVSRLDLC
AIVQKCLHSL SIMPSTFCPL WRSYIFKNCI MSGRSEYFLY SLKRLSTLLQ HLSLDHRRQY
FTEIQNLICS NHFHGDDQTK LIGAFSECIC VMANACDMNY DEEQKAKCRC CSGEFLKIDH
DSFAKYLPTF CPTRFLFDRI SEAKLANEYL ALLDLIRVVL VHCNLTENEV FEIYQKTCFL
IDFEDLSVRK KYSICIGLMA ALIDNDEFVE SIKSALSRVQ TGEFEHSSQS LLYYLGETAK
YAREALYEHA IVRFTIFTLA QVGGDSLLGL AAETLKDVCL MRGTTPKRLH VRFGCPIGRH
LVRLCCDVLR ESHGDRASSD EVGCILRNAA VLFDYGERQV AQFVQSSVRH LVPWLMIERS
NEASRAHVVV AKLLGTNRHC LLACNFRHVV LTITLNELPN DQVERVFEFI EREGSVEPAG
RKRGFSSVGG GGGGQRWTVA TYLSWDLYSC VNELLLHLSL NVERVLRMLL TIVHNFGRPP
DVSASAAEAE VIGFIKPRIL GVLIKFEEKF RSGDPVRDKL VALNSLDCLM LMCGGQILDQ
AKLKVLSTLR SALAVQDAQF RQLCSRAWHT FFTHLRDDAL KDILLSAVLT MLPLFEYEEQ
PQAQPDEARQ RKSMDYNESI LNFLFEQRAA LVGDELDALA FLLLEGEQQC RAPVALLRRL
RRPDACADWP LETALARCSA LLLGSESADI RRRCLVSLSG VLRRRDVELA RRLADADVVD
GTVARLHVAL MHCVRAGDES VRLLAASALG QLGALDPGRL PALDHRSEVE VPQPLLYADF
SADYNSRFGA TVLVELAKYM TAATDGFLYD ACSCTIQEVL NFFNCAQDKD TSQTSAGLLW
SILPTHVQTL ISPLLTTSYR FRARKNATID QRPIFGTPFG CNMKIWLQSW ISVLVKTIKN
ETASRFYKTV AVMTEYEVGF AHFLLPHVLF QKVIENDFDE VLNEVLKVLH SFNEKNNNLE
KSFCSAACQV VFSSTDFLRK WANRARAWPE KDTEREHVMN FLNSIPKNLL AECAMLCNAY
TRSLMYYEMH LDNSNANIEE HMPFLQKLYA YLEDVDAVKG SLTFRIAHGK PTLHEYILTY
ESIGNYHDAL PYHEAVTDAY PDDLSNHIAF VQCMLKLNQV TVSLRYIDGL RSENKEWSER
LHLCRAETLR RLQSWDLLKQ EIDEHPSSVG WDADLGRLML CVKERKCDSF QAEMSAVRSR
IMDEISVAMM DFASYERIYG SVLKLHQLYE VQQFLEQVGR AGEEDPNTVL TNLGHCWDSR
LKLLQHSSNV RHPVLELRRQ LLDFWPRCDE TIEMIGSSWL RSAKVARKAG HLQSAWSYLA
KVKGKNFDAV FVEEAKLLWL KNEQGEALSC LENGISSRFS KLFISPNQAE ADEHRPLFAK
AQLLLANYAR DSSSRDAFEV LDLYKKLLNT CPDNEQAYYN TAVHLDQIAQ TPSYRHSYHI
VLPKMVSSYG KSLKYGLKNL HHSMPRLLTL WLDSTARLHQ KQTKSKGDRD ADVGLSESDN
GQKMELLNSL NKIVRQLSDE LPIQLFYSCF SQLISRVCHP ADSTAEILKT IIARVIATFP
QQGLWMSLSV ATSTNPQRRQ ACKEVYEKAM ALNARVKPLL EDMTEFLELL KRLCYSAAGA
RRLSLSMSQD FPKLNSYFSN RRASRQPIIL PMQSMMDINM SVLKLSNSAC SDQKPVGTSF
PIQPVYIAGF ADTVEVLSSL QKPKKILIVC TDGKTYPMMC KAKDDLRLDK RLMEFNNLVN
TCLLRNAESR KRQLRIRTYT VIPLSHDCGL VEWVNNLEGL RHILGKLYKE LGDSMHSREL
QSAMARKTDS LGKKLEIFET VLLKRHPPVL SRWFGYRFAD PTEWYQARTN FVRTAAVMSM
VGYVLGLGDR HGENILIDST TGDVVHVDFN CLFNKGEDLE WPELVPFRLT HNMIDAMGPL
GCEGAFRKCC ELTMQVMRER RGMLRSVLET FLHDPLVEWT RNSNKPRPTA GEDKAREHLQ
NIETRLKGSV KASLDSAYGL PLSVEGQVAH LIRQAMDKKL LCQMYIGWAA FM
//
