ID A0A0V1L1J0_9BILA Unreviewed; 1232 AA.
AC A0A0V1L1J0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Exosome component 10 {ECO:0000313|EMBL:KRZ53238.1};
GN Name=EXOSC10 {ECO:0000313|EMBL:KRZ53238.1};
GN ORFNames=T02_14505 {ECO:0000313|EMBL:KRZ53238.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ53238.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ53238.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ53238.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ53238.1}.
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DR EMBL; JYDW01000170; KRZ53238.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1L1J0; -.
DR STRING; 6335.A0A0V1L1J0; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..463
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 865..945
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1094..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1232 AA; 140301 MW; 463269AAAB9EBEF5 CRC64;
MVWSLKLSFP SNLVYMCCIA NFINAVDRII MPIAIVELAE EMKYGIYQQG WVLSAFSAGY
IGSQILSSCI GAQWNSYGLL GFVVLLWSIS MLVTPYVASS FPLLMFSRLL LGLGEGLGLP
TIYKLFAEDV PSEKRSTAFS YLSSFASIGQ TMALVCCPHL HWRWPFYLFG MVGIVWCIAW
WRFLRYAPIL PFEQTSHVLK SFNLMKSWRI FFCSSQLLCV YVAHFCMNWT SYIIMHWLPV
YLRVGPVADW LINKRKLRVV RVRQLCTVIG LAVPAVFLIC FSVLDHVGLS LLVVSLCMGF
LAFNSAGHLS SHADLCRTYA GVSFAISNTL ATLPGLVVGP LTADFVMQSS GRWGPVFILA
AMLNLNFVAT LEQSTFFIDE IMAFGERMNA DKEDGDQSLS DLEEDESIVE QLRVAVANLL
KKCSPFRVGD QHLLAGDLKM LLVKASVQLL DLLNEAITYI SETFPKIPNG AHHTMMMNEI
AKINDILDER ITSSFDEVRG TSGEYLQDLR IERNAVEVAT ASWNCISVPS KEAVETERAV
ENFSEEMHFN NKRRFIPKPQ LNFRDQIDNT LNPFKTKLRI KHHGIPPEKL SSVKLFIQGE
QQLADNAGME CFSEPAHPYY YEIITCEPNS LMLSIKEPQH PIMPLNACKL VFVRSKKFLQ
SLVNDLNSQQ AFAVDLEHNS YRSYYGLTCL LQISTRDTDY IVDPFPIWHE MYILNEPFVD
PNIVKVMHGS SQDIQWLQRD FGIYVVNLFD TYHAMEVLEM PQRSLKFLVK ELVGVNLDKS
YQTADWRIRP LGSKMLAYAR SDSHYLLYCW DVLRNQLLNR GNEYNDLMMI VLKRSNDTCL
QVYKKKFPNE LELKKLESKF PFNLDNRQKY ALRMLYYWRD GVARITDESV YYIMRNDTLR
NLAAKLPRDM QLLENACKPI TGALMPHLHE IQKIICDAWC LDLFTMKSPK AETVAVERSS
VARRRPHDIY IDENKKELPL SQIFDRPVDE IVKQSMPISE SFKASSGETF HHVLLTSQSD
SAKSGTEKDE TAELLLLDDF AIFEKYCLTK EIRDVNKPEP ARIVWDVGYN DEQRKAAEEE
SEVCDEVIKI QSAGPAYSGG KTQEPSKMTD TQHNSSSLSI EKPNETLKAF YKPYDYSNSA
VRCFRGGSST GGDSTEARGT VSASQSADMA ARSRLFFKQN RGPFVRGKKF LVIFHVLSYA
SFLVRRRYVH LAYVLDGYEV SRSAGGVGEA HR
//
