ID A0A0V1L7X7_9BILA Unreviewed; 1331 AA.
AC A0A0V1L7X7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=Ptpra {ECO:0000313|EMBL:KRZ55643.1};
GN ORFNames=T02_155 {ECO:0000313|EMBL:KRZ55643.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ55643.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ55643.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ55643.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ55643.1}.
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DR EMBL; JYDW01000111; KRZ55643.1; -; Genomic_DNA.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00047; PTPc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF495; TYROSINE-PROTEIN PHOSPHATASE 69D; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:KRZ55643.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1331
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006881600"
FT DOMAIN 119..210
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 348..467
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 740..1018
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 935..1009
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1049..1326
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1241..1317
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1331 AA; 152147 MW; 66A662F0DE84EC56 CRC64;
MASRLFCTLP NLLFLLCFGV QYALFVASVL EEEMCEKTDD CVVDGQCLLP HDNADANGTR
FCFCSKSCIS SVPVECSRHK QCVVDSVEST HQNFCDKEKR LCLCRARKDN EHACLKKNLK
IIYLNTTRSS VYLGESFKIT CCVNIEPRSV RFRWFHNDTE IPSTLYPDLF QLCWTLNVTN
ARFADAGSYT CSVKTDAHGN AWLNASVDVQ VRGSRFFAFV REMDGQHLAV TKSTVDRPNV
TESRSDNSTN FFLMLNATGL NEATILLDWV ANPASSAIKF RVESLDEEEF AIEDVISADS
KPHIISGLKP ASHYSVSAET VPGRGRRPVY DKVVVQTLDK GIQAFPSPPQ QVNMRMKDEI
IRTKCELSWM APQVSNGPIL YYMVDVYGVI RRKSISQVNK MQKHRPKSVN CQNLNRVPPK
DSFMQCEFEG LLPNHNYSAR VVAVNALGES PPSMVNSKCL TSYGPPPHIE TPIAEKRFDD
KTIRILFSSI PDDIYGPITC YFLAIVPCTR NYNMSQLPHP VYMNFDVYER TMQSNLHIMF
QPIFAYISEA FYSLPRETII GDGRQTVGDV SSALEFLGRF PAQDGELQRG YKYTGFLIVR
VDPDNLVYNL TSNGKRELLQ NWLQPTYGFS NYFKPVFLGE SDVLITEDQS RGYQETIYLL
AVGFSVVSVL VVFGTVLCFY YSHIRGWLKT LLCVETNFVP DRNSFADLQR VAKRRDFQPT
AVEDLPNEYL LRHRDSNFLF TVEFESLPNY NFDTTASDKL ENAPKNRYND IKAFDITRVK
LERVDDDSSS DYINANYIQG YKGRKLFIAA QGPTLDTVND FWRLVWEQNV NVIVMVTNLQ
ERYRTMCIKY WPEHSPSVYG RIEVKPLDCT FYADYVIRNF TIRRCRTTAD VSNMSSSAAV
GNESESNNLL NGDCRSIVQY HFTGWQDYRA PEGSYGFLRF MKQFKRIDCT SDCPVLVHCS
AGVGRTGTFV AVDSMMDQMA EEGRVDVFGF VSNLRRQRNF MVQSLDQYVF IYKALAEWYM
FGDTDVDAER AEEYVVELRQ TLNNDSTGLE KQYNLLFRSL EDALTCNYAK KSFNEQKNRF
KTVVAYDRNR VILAPLLGHE DATYINASLV RGYFYSYILT QDPLSNTRWD FWRMILEHGV
ASIVMLTGEE FLDQDEMYWP SELNSSICFG DKPAITVELL CEEQSAHYSQ RKFKITNTKE
KELHEVVQFC FHDWANGSSR IGQFGERKSS MHPPSIPTST ASLFDLVGKV SQRQNLLQDA
GPIVVHCRDG AERSGLYCAV SLLLERLRGE GKVDVFQTVK SLQAQRPHII PNVAQYDFCY
QCVLDYLRSF S
//
