ID A0A0V1LRF9_9BILA Unreviewed; 957 AA.
AC A0A0V1LRF9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=orotate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00011971};
DE EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
GN Name=UMPS {ECO:0000313|EMBL:KRZ62111.1};
GN ORFNames=T02_12375 {ECO:0000313|EMBL:KRZ62111.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ62111.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ62111.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ62111.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ62111.1}.
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DR EMBL; JYDW01000012; KRZ62111.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1LRF9; -.
DR STRING; 6335.A0A0V1LRF9; -.
DR UniPathway; UPA00070; UER00119.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 2.
DR Gene3D; 3.40.50.2020; -; 2.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR HAMAP; MF_01208; PyrE; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR023031; OPRT.
DR InterPro; IPR004467; Or_phspho_trans_dom.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR00336; pyrE; 1.
DR PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00215; OMPdecase; 2.
DR Pfam; PF00156; Pribosyltran; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF53271; PRTase-like; 2.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 2.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721}.
FT DOMAIN 733..938
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 957 AA; 107734 MW; 3B373B968E6C8F42 CRC64;
MGATGLGEHR ITVHLSSCHL LFTTTLLKMD ARYETFLTDL FHLGAIQFGE FMLKSKHTSP
IYVDMRRLLS HPTLLNTVED LMYDYAKELE YDVICGVPYG AIPLTSALSV KRSIPMIMQR
KDAKAYGTKK IVEGLYKPGD KCLIIEDVIT FGSSIAETAR VLRAQGLIVT DALVILDRCQ
GASRNLENLG ITKWSLFCLP DVLLLYEGRG LISNADCQRI SSYLFNVTDK IAPSALGNGL
QEGAKVDKTG VLSVKAASNT ASLSHNLAKH LWQIALDKKS NLCVACKLSD PKEIIAVAEL
AKKIGKFICM LIIRSDLICK VPLVDFISEL KTCAKSKNFM IMDDRKFCDV SSIVEMQLTG
GEWSIAKWVD FVTVLPFSGR GVFSAIRKVS TENKVACFSI LSLHAKDSLI PKEFSEQSMK
TAEKDIDVIA GVVCSKPPVL DSRFLYMTSA DESDQALLRF EDFDKMQFLD VEYLEMNHGI
QYADIYKVWA FTLLNKLFNI GIFKFETVVM RSLYETPIFV DFQLAVSYPE IMNEIEELVH
SCLLSNLKFH SICGVPEGGL PLASIISVKR NIPLLLYHKT KETTVTGKVI DGVWKKSDNC
LIVDDVLMFG HSLADAADVL RQHELEVTDA IVLLDRCQGP ENFLKSNDIR RHYLFNLTDV
LSYLNEQALL TDFECLKISN HLLAFSDLAG KFVDQCTIDE RMEPLFFSPD RLSMILHPKA
RKLWEIALSK HSNLCFACDL CSPREILRLV EAVAVNICSL KLHADLIVIK EMPDFFSRLK
RLAQSKKFML INDGNYCDDS DVVVELMLNS ATKPASWADF VTVQCLNGSS VNSDYSVACL
PVVEMSTSGN FFTEEYKKRA LSLAQQYRQI VAGFICQKRP INDPSFLYIS PGVHYKRRLD
DQNWRTPDKA VRFNRDDIVV VGRGITKEKY SRVWAYTYQQ ISWDAFIIMN NAAANVE
//