ID   A0A0V1LSU3_9BILA        Unreviewed;      1009 AA.
AC   A0A0V1LSU3;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE            EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN   Name=MAN2C1 {ECO:0000313|EMBL:KRZ62563.1};
GN   ORFNames=T02_3322 {ECO:0000313|EMBL:KRZ62563.1};
OS   Trichinella nativa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ62563.1, ECO:0000313|Proteomes:UP000054721};
RN   [1] {ECO:0000313|EMBL:KRZ62563.1, ECO:0000313|Proteomes:UP000054721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS10 {ECO:0000313|EMBL:KRZ62563.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRZ62563.1}.
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DR   EMBL; JYDW01000008; KRZ62563.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1LSU3; -.
DR   STRING; 6335.A0A0V1LSU3; -.
DR   Proteomes; UP000054721; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054721}.
FT   DOMAIN          509..586
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1009 AA;  114621 MW;  ED85FFD4742EE1FB CRC64;
     MAYVEASLFK NERTTHCNLY GKIYGKTQPV KIFGCKIFGR APFNEAMKEI EKFGEDVEVG
     FEMSPTWATY WFRITCTIPN DWIGEKVCFS WDSGSEVLVW NSNGTVSQGL SGDAGRTLYV
     LSNKVEPDQL EYIFYVEVAC NTMFGAGSDD TIAPPNAFRK FFIKKAEIVV INEEAFQLYM
     DFDVLNSMIS SMPADSPDRY KALYTANMMV NMASDMNKES IMKAHALAVG FFCNKENCPL
     NFTVQAVGNC HIDTAWLWPY AETKRKCARA WSSTLRLMEE YPDLTFACSQ ALQMRWVQKF
     YPDLFAQIVK RVHEGRFVLV GGAWVEHDGC LPSGESFVRQ LLYGQSYFKE NFGVTCTEAW
     LPDTFGYSGQ LPQIFASAGM RRFVTQKLSW NVVNKFPNST FLWEGIDGTS VVAHLPPGNS
     YVMENTVSDV FKTMANFQDK GRSETALLLF GKGDGGGGPE REMCERLVRS QRLPGCPAMK
     PTTPASFFED VEATDMQNLL TWVGELYLEM HNGTYTTQAE VKRKNRKGEF LLRDCEMLAA
     MRFVLDSGGD VRSFYKEWLQ LLQNQFHDVL PGTCIALAYV EANRMYQQLT SECENYLDES
     ADGEFLMNTL GWSRRLITET DAYLVPAFSI IRKRDAVCKI DDRVHVEQID ELIVMKNKFV
     EIAIDDRGRV VRLNLPDHCN VIADGMPGNQ FTMFDDVPLY WDAWDVMDYH LETKRLLTNV
     TEGPTFGISE NGLTAWVEFT LQISESSNLK QRIVLQAHCP YVQFDSSVIW MEKHKFMKVQ
     FPLNVRSQEA TYEIQFGHLS RPTHRNTSWD SARYEVPAQK WADLSMYGSG MSLLNDCKYG
     YSCYKNILVL SLLRSPKRPD PDADIGGHKF SYAIMPHCGQ FQRAVHPDTV NVIQASYELN
     CPIRVLKAPF VDNSTVWDRQ FSLLSIENPA VILEAVKVSE SGDRLLLRFY ESFGGQAETT
     ITPLAFGVKS CFTCNSLEIP DKPVPLNHSG TFQLQFGPFQ IVSILIEII
//