GenomeNet

Database: UniProt
Entry: A0A0V1LTB4_9BILA
LinkDB: A0A0V1LTB4_9BILA
Original site: A0A0V1LTB4_9BILA 
ID   A0A0V1LTB4_9BILA        Unreviewed;      4308 AA.
AC   A0A0V1LTB4;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   22-NOV-2017, entry version 12.
DE   SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:KRZ62742.1};
GN   Name=Ryr2 {ECO:0000313|EMBL:KRZ62742.1};
GN   ORFNames=T02_6875 {ECO:0000313|EMBL:KRZ62742.1};
OS   Trichinella nativa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ62742.1, ECO:0000313|Proteomes:UP000054721};
RN   [1] {ECO:0000313|EMBL:KRZ62742.1, ECO:0000313|Proteomes:UP000054721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS10 {ECO:0000313|EMBL:KRZ62742.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRZ62742.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JYDW01000006; KRZ62742.1; -; Genomic_DNA.
DR   Proteomes; UP000054721; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054721};
KW   Receptor {ECO:0000313|EMBL:KRZ62742.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    817       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1045   1226       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4233   4268       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4271   4303       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4246   4257       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4281   4292       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   4308 AA;  489958 MW;  708164CAACBFEAF5 CRC64;
     MTDFQENSTG EQDDISFLRT GDVVCLTCLA PCKESGTGSA ERVSLAAEGF GNRICYLENV
     SDKNKPPDNA TSMFYIDQAL SVRALQEMMS SESPNISGSS STHRTLLYGH AVQLKHALSG
     MYLTCLSTSS ASDKLAFDVG LCETNVGEFC WWTIHPASKQ RSEGEKVRFG DDVILVSVAT
     ERYLHMSSTN GNTVLAAFHQ TLWSITPNSS GGVRERHMGY VCGNDVLRLN HGNDECLTIP
     ENWSDSHQNN IVIYENGKSC NQARSLWRPE LIHGKWQSSL IGWEQAFRIR HITSGRFLAL
     NEDNQVCLLH KDRASFESTA FIMISSKDVK RSTFEEKEEE GMGVATVKYG ETVIFLQHLQ
     SNLWLSCQTT AVTKKNMGKV EEKKAIAVEE ARMDDCFILF KAQEEESQSA RVIRKCSQIL
     NRFLRGLEGL QMEGKDSLAW NRADLSETVK LMEDLIQYFA QPEESIDFES MQNGLRALRN
     RQDLFQEEGL LNMIIDTIDQ FSAVESMTEL LDVTKEDKCK NWQDISTYLY LLVAAMIKGN
     HSNCTQFASA QRLNWLFSRL SNPQSAEGIL DVLYCILTES PEALNMINED HVKAVISLLE
     KVGHDPKVLN VLSALCEGNG VAVRNSQNVI CSELLCNKKF LLQTKMIDQV SSVMANIFVG
     SYENSAMYPR WYFEAELEYM ESMRTSGQKP HLRIGWASSA GYRAYPGSGK KWGCNGVGDD
     MFSFGFDGQY IYAGIAALKL SKLIGGIEKF VGTHEIRKGD VIGCSIDLAI PEIQFSLNGH
     QIGTSVRNFS SCDCLFYPVM SLSAIVSCRF FFGGSQGKLR FGPKKGYLPI SEAAITPVKL
     ISCISFGDTR KGYFSGPSTV ISDYIVFQPK PIDTKDVSLP KHLEDVHEKL AENIHEVWAM
     DKIEKGWIYG ERRSETQKTH PCLTSYERLP TAERSYNLNL AKETLKTIVA LGYRIDIGKA
     SNRVKTFRLG QNFLMSNGYK PAPLDTREYE LNETLETLVD LLAKNMHNIW AQSKIQRGWT
     YSKNENVNIK TTSHLVAYDF LDPNIKAANR DKAGQIIRSL LVYNYCIEPP TAEQDEGAVK
     QSQVMNLQKR TYRFEKRYAV KSGKWYFEFE VRTSGFMNVG WMDVSASPDG DFGLHKSSYA
     YDGYLGRKWH GESESYGKKW NVGDVVGCFL DLTDRTICFS LNGELLLDSS GTEVAFDNVS
     AEDGFVPAFS LAPGQIGRLN CGQNVNTLKY YTTCGLQEGY EPFCIRMSRQ APMWIAKCEA
     EFDEINEEEK RFKVTRIPQS GDNPPCLKLQ CKSAGMLERC SLALFRLNLP VFCKEANDNR
     VCNQYFTETL SERNAGKRNG ESDRTAESSR RGKMKGIRGS RNQDENISFH DQQNYADQYE
     VSNHAVMKSN CLVQKTFSLD DDSSEVTENR FRKAPRLRSS ASEANLKEKE SIDSQDKISA
     SYAVSNTKRN LRPFKVLQSF GQRMRDVSVG RSRKQNARKL QEACASKSKI RSDENDKFSS
     GHLKSRKLDD RVADVDSTES LDMPKSGPGR RPTVIRLESD SKVKKRSNYF SSGHDLLVEA
     SKLSAPSGNQ HVSIGASVSF YSTPDDYYFG VRVFPGQDLA NIWIGWLTPQ FSFTGSQIAA
     DSQRICFLES THSTLDNIQE FRSCYIVNGM ELLTAAGGSS SVSKMAGILA GCLINTATGE
     LKFHVNGKQT EMSYRVEPGT ILYPAVFVLP TSREVLQFEL GNIEKTLPIA SAQLNERSNA
     VQLMCPPRLK MEICKTRTWL RVPDQCARVT SLKLSDTRGW SVLCDDLVRT MMLYVPERDS
     SIDILELAEH ESLCTFHQQT LRLYCSLCAQ GNFKIAHILC QHVDEDQLMY AIQSKYLSGS
     LRQCFYDVLI AIHLKCHYDA RLAESHEYII PLNAKLKDRN YFNYETKSVY PHALNSDITL
     KSSINVMEVK KKISTEDEKF LMSPTFDFHT LKQYVVDALE EATLEALMNS RDLIGGTNTT
     HFLPILKLFD TLLLVGVLSD TDIHRFFRLL NPKSFQETLD SPQNVKGLVD LDLDEMVQLE
     LCHIMNHLCD LQLQGRVESL INFAETFVGE TQNACALDEI FEKSNLCFNY LRDQLRRYLE
     IKQTDMPSAE AARKTKEFRC PPKEQMLKLL DFKADRDEQT DEEGELEVSA MSEFLQRVLR
     EFHCNMVKFI GNSDKNDDNY SANVEQKQLE SENMNWVEKL AWMVVPVPPA LLSEDERIKF
     DGEEAFRNII LSTLIKWTGN KAIDDPNLIR EIFGLLLRQY TRISEVKSAL KTAYCIHERS
     IEDVQSFLDN LCQIRRLLCV QFEATEEEVL KNSLWDMMNN KVFFQHPDLM RLLKVHENVM
     TIMVNVLSRA QKSELDDRRN RSAQDDMKKA FQNSISDLVV ACCKFLCFIC RSSTKNQAAM
     FEHLPFLLDN ATMLLAKPSL RGSVPLDVAY YSFMENSELA LALKEDDLEK VAFYLSRCGL
     QANAEMVFKG YPDIGWDPVE GERYVDFLRF CVWVNGECVE ENANLVIRLL IRRPECLGPA
     LKGQGEGLFR AFKDAISLSS EISNLHKGRD LRSRFNFDLS HYPNPEIEEE DYIDLGAAIL
     GFYSSLADLL GKCAPDHLTV KSGKGESVRL RSILRSLTSV EDLEAILALR FLLPNVFAAK
     EESFRSSSIG LLPCHKQSIL LFLERVYGLI DKEMVFRLLE QSFILDFRAA TILDHPAYAE
     SDLALALNRY LCGSVLPLLT SHAHCFADAE HYYSLLEATL HTVYRMSKIK SLTKSQRSAI
     TEFLLAFTKE IHPGMMKKLL QKVVVDISSL NEFATVPLQI MTQHYECFSK HYGISMHEDT
     ASEEQKRLSM LLFTTIFDSL GKRAFDSDLF ASALPCLTAI GSALSPDYAM QSYAEEEIQN
     MNVPSGHMEV WRPHPVDASN VQLSVNLQNL VQRFAQHFHD SWASRKLEKG WRNDDIYSRT
     NCTHPRLKPF GMLKEFEQNF YKERCSECLK ALLAWGYSIE QETQVSSVQP KSMNPTSNVR
     SASVFCPQPI DLSNMTLSEE MCELAERIAE NSHLIWVSKT IEDLNDANTG IMVLLVPWDI
     LADSEKRKHR FRAQEVLKFL QYQGFRLKSP LHRAREEYQQ TVVDSNTHRP VEKRFACNLL
     EKLLAYLENA AQKMEVIKPS KQFSRYRNYT LPSEDVKFFG KVLLPLLESY FRSHRNYFTA
     ASSASLSGVA SIKEKEMVAG LFHRLMSVFR SKHNAFGCHV KSTVRCLQVL LQAIDFRSLV
     KINSDTLRTC AQIFLSNMVS DLMNITKEIK NNGRYAEIKG KTLPCTSSLL FLYEAMLPLL
     TTLFCHLSKH GHGQDFLVND IQVGCYKIAD CLYMLASPIT ISRKSVKEEM EKHRSSIGQC
     LSAFACCFPV AFLEGDFNPN SRGSTVDRQH LLSESKDTSS SLLLNIPSLD NLLSNIEQLS
     NTNGKYQDAP AIFDVDIPML CSYMSFWWQH GPTNNTQELI KFIFMCIMML YEIYFRKNLS
     AVSSDHINRL FSACSRLICD HIGIAHADWI CHLAPFITPM INYVTIEPVR DYLLPMAEKV
     RMQADLAFKE EEKHRMHPDV FDESTVIELH SILIRDVYAL YPILIKFTDL HRARWLKNPC
     WETNALFEHV AFVFKLWSTS QHMKREELNF ITQFESDFMT GTSRKTGKAA VAFRKKKRRE
     GKRREKDSGS IVVACLKRLL PVGLSVFGGR ELDLLQKVKE KYMKKENDEK IKEYISSSLA
     IPDQEDVFDK SHWQRKLYQQ IGKAQMLGID SMSQEMVLDK IIFMGVTLCN LHNVEHPQTF
     QADAWRKIVS SQRKRAVVAC FRMVALYSIP KHRCVNLFLS AYIEKWLKSE KVDEDLLISE
     VTVASEGRMQ RLREDVEEVD EQCPPDPLSQ LVQCFQRAAT SERKQLVPIV DDNLYIQYVR
     VMASSIHIND DEQNNAEDDA ISMEAQELEK QQLLHEQSRL ADRGVAVMVL MYLSACNGEP
     NVMVEKTLAL GIHILNGGNS DVQNIMLNYL QEKKDVRFFS SISGLMNRCS VLNLEIFERQ
     LKAEGLGMGA ELSVGKHQNL NDSEFICSLF RFIQLTCEGH NSEFQNYLRN QPGNTTSINL
     IICTVDYLLR LQESIMDFYW HFSSKEVVDE AGKAHFLKAL SVCSQVFNTL TESIQGPCVG
     NQMALANSRL WDAINGFFFL FAHMMDKLSK NHTQLELLRE FLSLQKDMIV LMLSMLEGNI
     LNGSIGKQMV DTLAESQQNV QLILKFFDMF LKLKDLTTSQ AFQEFDTNKD GWISPKEFLR
     AMEAQKMYST EEINYLMMCT DVNNDGKIDY MEFTERFHNP AKDIGCIQ
//
DBGET integrated database retrieval system