ID   A0A0V1M3B6_9BILA        Unreviewed;       574 AA.
AC   A0A0V1M3B6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=type I protein arginine methyltransferase {ECO:0000256|ARBA:ARBA00011925};
DE            EC=2.1.1.319 {ECO:0000256|ARBA:ARBA00011925};
DE   Flags: Fragment;
GN   Name=carm1 {ECO:0000313|EMBL:KRZ66388.1};
GN   ORFNames=T10_2223 {ECO:0000313|EMBL:KRZ66388.1};
OS   Trichinella papuae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ66388.1, ECO:0000313|Proteomes:UP000054843};
RN   [1] {ECO:0000313|EMBL:KRZ66388.1, ECO:0000313|Proteomes:UP000054843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ66388.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) +
CC         N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC         COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319;
CC         Evidence={ECO:0000256|ARBA:ARBA00001817};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRZ66388.1}.
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DR   EMBL; JYDO01000246; KRZ66388.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1M3B6; -.
DR   STRING; 268474.A0A0V1M3B6; -.
DR   Proteomes; UP000054843; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR007848; Small_mtfrase_dom.
DR   PANTHER; PTHR11006:SF10; HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED; 1.
DR   PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR   Pfam; PF05175; MTS; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51678; SAM_MT_PRMT; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015,
KW   ECO:0000313|EMBL:KRZ66388.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01015,
KW   ECO:0000313|EMBL:KRZ66388.1}.
FT   DOMAIN          145..254
FT                   /note="Methyltransferase small"
FT                   /evidence="ECO:0000259|Pfam:PF05175"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KRZ66388.1"
SQ   SEQUENCE   574 AA;  64501 MW;  5BD5D39F5E11174A CRC64;
     LNMFSGVKIC TLDNNLKWTN EQKLESLTVD QDKIMYLVHE SEMCESSISL VNFDHMLIKE
     QCIILNLKND NTTMMLTFSS NEDRQDFIKL LSNASKTEVV DSGLSRFDQR TEEASASSYF
     QFYGCLAQQQ NMMQDFIRTS TYQRAVLANL DDFKDKVVLD VGAGSGILSF FAVQAEAKTV
     YAIEASSMAV HCETLTKSNG YGDRIKVIAE KVENAVLPEL VDTIISEPMG CMLLNERMLE
     SFVHARKFLK PGGTGKCIQL LVICTLRHSQ MRFFMPKLVQ RPIFGIFLTL ILKTAQDHFH
     GINLSALKNQ GFLEFFRQPI VDTFHCGILM AQGLKYTIDF STCAEESFQR IEIPFDFEMK
     RTCFIHGMAF WFDVAFIGTN TTVWLSTSPS EPLTHWYQVR CQIMHPLFCK IDSHLTGTVI
     FVANKRQSYD IELTMSCDGK STTNVLDLKY PFFRYNGQPV QPPPGNQNIS PTDAYWSMVR
     QQPTPSEQPF AVNGNGAVVG VDVNDPQSMA QNAVNAWNAA GTSTSSFSDS AFSAAGYNHL
     GGPGYVGTVY DSSLMFYPEE ENSIQVADYN MTRG
//