ID A0A0V1ME89_9BILA Unreviewed; 790 AA.
AC A0A0V1ME89;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=DNA mismatch repair protein Msh2 {ECO:0000313|EMBL:KRZ70232.1};
GN Name=Msh2 {ECO:0000313|EMBL:KRZ70232.1};
GN ORFNames=T10_4077 {ECO:0000313|EMBL:KRZ70232.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ70232.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ70232.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ70232.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ70232.1}.
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DR EMBL; JYDO01000118; KRZ70232.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1ME89; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843}.
FT DOMAIN 666..682
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 790 AA; 90082 MW; EB80D256AA5ADCC8 CRC64;
MDKDLYGIFA KIIERVVREL LLVHLYRIEV YRCSSARSQD WELSAKASPG YIREFENILT
NCEELQEQSR ILAFKITEET GNICKLNVSM VCCDLFHHTF QICDILDNDN LANFKRILAQ
LRPKECLTVD SSVTLNQMRK NIFSQIAIPV TTLKKSDFNS SNVLNDLDML VKFKKGSHGF
CGSLPEMKMS DTILQCFAGL IKYFGLMNDD CFLKQFQIQY FTPEKHLRVE WSAFESLNLF
RFGGEKSADN LYGILNHCQT AIGQRLLHEY LKMPLLDKNK IDERLDIVNL FVQNGEIRNI
LQQELLCRFP DLHRLCRKFV IKRAGLAEVY KVYSAVNCAS DMLKVLDKLN TSVIKDNFTE
PLLMTLDDFQ KFMEMVSMTI DLDYIARTGE YRVKPEFSQF LQDLNNCMQN IDQKMTSYLA
KAMKIYGFEH GKSLKLEYSA QWGHVFRVSR KDEKIIRNQK AVELLDMQKG SVRFTDETLK
RMNSEMMKAK DSYEEFQKRV VDELVATVAT YMDPMKSLAQ VVGHLDVMVS FAIASVNAPV
QYVRPKILQS GSGILNLIQA RHPCLEMQPD VSFIANDLKL AKGEAELIIL TGPNMGGKST
YLRQTAMIII MAQMGCFVPC QEATISILDA VFTRIGASDN QYKGLSTFMT EMVEVSEILE
LPSENSLIVI DELGRGTSTF DGLGIAWAVA ETIATKVRAF CLFASHFYEM TMMASELFMV
KNYQALATFS ENNLVLLYKI KPGMCDRSYG INVAEMVGFP EIVLKEAWKE ARRLEAHGRG
GIDEDGSDQQ
//
