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Database: UniProt
Entry: A0A0V1MEB9_9BILA
LinkDB: A0A0V1MEB9_9BILA
Original site: A0A0V1MEB9_9BILA 
ID   A0A0V1MEB9_9BILA        Unreviewed;      2198 AA.
AC   A0A0V1MEB9;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-SEP-2017, entry version 10.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=Ca-alpha1D {ECO:0000313|EMBL:KRZ69840.1};
GN   ORFNames=T10_13548 {ECO:0000313|EMBL:KRZ69840.1};
OS   Trichinella papuae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ69840.1, ECO:0000313|Proteomes:UP000054843};
RN   [1] {ECO:0000313|EMBL:KRZ69840.1, ECO:0000313|Proteomes:UP000054843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ69840.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRZ69840.1}.
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DR   EMBL; JYDO01000127; KRZ69840.1; -; Genomic_DNA.
DR   Proteomes; UP000054843; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054843};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    139    157       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    177    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    210    230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    270    289       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    351    372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    384    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    515    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    551    576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    583    601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    638    658       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    679    696       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    708    731       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    875    893       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    913    934       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    946    972       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1007   1026       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1117   1144       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1198   1216       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1228   1248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1268   1287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1294   1313       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1359   1379       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1445   1469       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1625   1659       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2198 AA;  251939 MW;  29B63A193473EF2D CRC64;
     MGRSIFVGTV NPALSKSSVP LPIPEHLRAS LQLDHDHHAR SEANFNDDVN IGKELSGNEA
     AALLHGDEAR ASRADLWQQT LQAAVAAQTE SSTTTKKRQQ QRKMQRNVQQ ERPERSLLCL
     GLKNPIRKLF ISIVEWKPFE WLILCMICAN CIALAVYQPF PAHDSDRKNA VLEQVEYIFI
     VVFTIECVMK VIAYGFLFHP GAYLRNGWNL LDFLIVVIGL ISTALSTLNI HGFDVKALRA
     FRVLRPLRLV SGVPSLQVVL NSILRAMVPL FHIALLVLFV IIIYAIIGLE LFCGKLHKTC
     VDQWTGEHVP DPGPCGESHT SFHCDRSKNL VCTENHTWPG PNDGITNFDN FGLAMLTVFQ
     CISLEGWTDV MYWVNDSVGR EWPWIYFITL VILGSFFVLN LVLGVLSGEF SKEREKARAR
     GLFQKFREKQ QLEDDLKGYL DWITQAEDID LVNEEDEEQE AMDREEFGAD GEGGEEGGSK
     EEYQRQSWFS MKIKRLKKLN RRCRRSCRRI VKSQAFYWLV IVLVFLNTMV LTSEHYGQPE
     WLDHFQEIAN LFFVVLFTLE MFLKMYSLGF VNYFVALFNR FDCFVVIGSI LEFALTFAGL
     MKPLGVSVLR SARLLRIFKV TKYWNSLRNL VASLLNSLRS IASLLLLLFL FIVIFALLGM
     QVFGGKFNTI DPNMNKPRAN FDTFVQALLT VFQILTGEDW NAVMYNGIAA FGGVHSIGVI
     VCIYFIVLFI CGNYILLNVF LAIAVDNLAD AESLTAAEKE EEGKRVNEAD PDDAMVKVPA
     DEDAVSVEQF HESGEVKLPF NEPTDAEDEH LASGDEDQER EMENQSQFKP TARPHRQSEL
     NLPKKTKPIP DASSLFLFSS TNKVRIICNK VINHSYFTNS VLVCILVSSA MLAAEDPLQA
     SSFRNEVLNY FDYFFTTVFT IEISLKVLVY GLILHKGSFC RNAFNLLDML VVGVSLTSFG
     LKSGAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVIVA VKTIGNIMLV TFMLEFMFAI
     IGVQIFKGAF FRCTDRARLT AEECKGTFIE FEGGDVTRPH VRSREWTNYD FNFDNVQNAM
     VALFVVSTFE GWPDLLHVAM DSSDEGIGPQ YNARVSVAIF FITFIVVIAF FMMNIFVGFV
     IVTFQSEGER EYENCELDKN QRKCIEFALT AKPQRRYIPK NRFQYKIWWF VTSQPFEYAI
     FIIIILNTLI LGMKHYKSSA AFDEALDVLN LFFTTVFALE FICKLFALTF KHHKMTRTFD
     DVLDTMNLIF TGIFAMEFIL KVMAFRCKNY FGDAWNVFDF IIVLGSFIDI IYGKPGSNII
     SINFFRLFRV MRLVKLLSRG EGIRTLLWTF MKSFQALPYV ALLIVLLFFI YAVIGMQIFG
     KIALNSNTEI HRNNNFQTFP SAVLVLFRSA TGEAWQLIML SCANTPTAMC DPESDDRGQP
     CGNDFAYPFF ISFFMLCSFL IINLFVAVIM DNFDYLTRDW SILGPHHLDE FVRLWSEYDP
     DAKGRIKHLD VVTLLRKISP PLGFGKLCPH RLACKRLVSM NMPLNSDGTV CFNSTLFALV
     RTNLKIYTEE RPFLFLKKSE KVESQSLVSS NIEEANEQLR AVIKRIWKRT PQRLLDEIVP
     PSGRDDEITV GKFYATYLIQ DYFRRFKKRK EVEQKETNLQ GNITMSLQAG LRTLHEIGPE
     IKRAISGNLE TDWSKEFEEP QHRRDHSLFG TLVHALQAHY KPFIEGNLAN PAYSNVNGDL
     KSQEGDDEVE QHQHQEQEPQ HQHQQQPQPQ QMMMMFKMND LKSPPVKSDR DKISEFESDE
     SVCNKPERRC NSFFSNIRRR VDSIVSPSIM LFDSDHDSSE HEMQERVRFV PRGSKPTTGL
     SFEGSRWLPR KLSFRRAPIG AAVSNLQQGN NKRLQFSNAI ILDDSDPDSI MHPENVVDLT
     ESGDDSKSSV SPPLELRDDA YYLDGIDYNT WRPAPMGQGV RLRRRGNNGR RKSRSMPLPH
     DQRNYADVLV EKVLADQGLG RYADPNLIRT TQLEIAEAYN MTEAQMHSAA RSLMQRSPKY
     FEHMGGQRPA DIKDFNQYSK TALLKPREMN NSEDVDISDD MNMFMRKVGL KQVGCLWIAM
     FHCAVTEKRV SELFGKRTSN EDDMILFLAN INEEEMRMFL QRLLFEWRRA RKYWSELNDE
     KLTQMEIGKR MSELFGKRSE RHHPSDGYYK KRVSELFG
//
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