ID A0A0V1MLV4_9BILA Unreviewed; 1069 AA.
AC A0A0V1MLV4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN Name=Supt5h {ECO:0000313|EMBL:KRZ72634.1};
GN ORFNames=T10_3214 {ECO:0000313|EMBL:KRZ72634.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ72634.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ72634.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ72634.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ72634.1}.
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DR EMBL; JYDO01000076; KRZ72634.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MLV4; -.
DR STRING; 268474.A0A0V1MLV4; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 5.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Elongation factor {ECO:0000313|EMBL:KRZ72634.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000313|EMBL:KRZ72634.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 174..263
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 428..455
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 480..507
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 602..629
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 708..735
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 779..906
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT DOMAIN 1018..1045
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..67
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..106
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 118571 MW; 19DCAABC98591985 CRC64;
MSEDSDVDYP ESGADAEDIH EEESLSDQEK VHKRRSRDRP KWRKKKFSDD DDDDDDDDDE
EYDDEEEDEQ PKKKRFGAAR EFFLDEVEVD DDDEEELPEE GMEDEAREAE AALAAARLYE
RRRNRAQIWK DMTEDEINQY FKNKYSRSYN TSASIDDSIY DDITQKGLLP SASDPNLWYI
KCRIGEEKTT GMLLMRKFLA YQNTEDPLLI KSIIVKEGLK GMIYIEAYKM PHVMRAIEGV
STLYKNHVRM VPIKETPDVF KVIKDTSALK PGVFVRVKRS VYKDDIAQAE RCCDKLDKQV
LVDWVDLSQK SIHLKLIPRI DYTRMRGAMR NTGETDIPKK RKARPPAKFF DLDAVRAIGG
EVGKDGEFYI FEGNRYSRQG FLYKSMAISA VEANNVKPSL AELEKFQVGV DDLKSELANT
LVREEHGQFA AGDVVEVVEG ELLNLRGKVT SVDGDTIHVQ TAMPELKGTL KFSAHELRKH
FVVGDHVKVI SGRYEGDTGL IVSINPNCVI LMTDLSMSEI QVLPKDVQLC RDVSTGVHSS
GTFQHHDLVM IDAETVGVIV QMEREYLHVL NQNGKVVRMK HQSLYGKKNS KYAVALDCEG
NNIGVGDVLK VIDGPNKGLQ GEVKHLYRSY LFMYSTAHHK DGGMFVCRAR HVLTLGLNTF
GEEGRKEYSS SPRGVLRSPM HPGGGGAAAR GQMSTPYYIG RGRVCRDYGA IGKSVRIIKG
PMKGYHGMVK DATESTAQVE LHATCKTISV ERSHLEVLSG NGEPSQAFQP YKSMRPPDGS
QTPYADMGKT PRYGSHTPMY GSQTPMHEGG RTPYYGSQTP MHDGSRTPSH ANAWDPTVPN
TPARRGVSDD DFEYEASPVT KYGGPASVSP ATPGYSVDTP LGVPYTPGDL FSENSSPFLM
QSANSPLLGS YAGSSVGESP SLQPSTSGLS LFSTGSRTSL STPSSSITSD SPKLSFDGNL
GEWVEPNMEV VIRDYPGDRM LNGRVGLVQA VTGDSCTVFI SSLEKAVSVY VENLEPSKPL
QGDKVKIIRG EDVDSTGLVI SIDGVEGVVK TDSDEIRLVN MAFLCKMVS
//
