ID A0A0V1MNV5_9BILA Unreviewed; 1306 AA.
AC A0A0V1MNV5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 39.
DE SubName: Full=Calpain clp-1 {ECO:0000313|EMBL:KRZ73508.1};
GN Name=clp-1 {ECO:0000313|EMBL:KRZ73508.1};
GN ORFNames=T10_12571 {ECO:0000313|EMBL:KRZ73508.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ73508.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ73508.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ73508.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ73508.1}.
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DR EMBL; JYDO01000062; KRZ73508.1; -; Genomic_DNA.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF419; CALPAIN CLP-1; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 2.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}.
FT DOMAIN 44..79
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 113..148
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 299..385
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 396..484
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT DOMAIN 839..1135
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 894
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 1050
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 1075
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 1306 AA; 143996 MW; A8FE7BE9BEE7FEC9 CRC64;
MSQRSAQLSK GPDVEKHTKN DPLEHGRGEG VKILPTHFYP LSEEQENRFR DIYNKLDLDR
DGKVNIRDLI YVLNQRMPTV QHRHSYAMNI MEEANKKHGE SLSFADFVHY MLEHEQRLTL
VFNDCDRNQD GILDSVEIKN YFVELGMPIS DTQAQKIVQK MATVNKEGIG LDEFLNYFMF
YPCSYPSDIA NHWRHNLRFD IGEDSLIPED FSEYEFRLGA WWQHLVAGAT AGTVSRSCTA
PLDRLKVFLQ VHATAENNVR FTTGFKMLLK EGGLKGMWRG NGVNVKSFLK FNSESSHELS
LFERFLAGSL AGSAAQTLIY PLEVLKTRLA LRKTGQMNQG ILHAFQQIYR KEGIHAFYRG
YVPNLIGIIP YAGIDLAVYE TLKAWYMRKH PECDDPSPLV LMACGTLSSI CGQLTSYPLA
LVRTRLQAHA KSPTCQPETM SEHFRYILQT EGFFGLYRGL TPNFLKVLPS VCISYVVYET
VRKRLGATMT EEKNQIHECI EQMAYYDDRG YGDDHDYRYA DEYDDEEESE ECQQVIVSPD
EFGGLIGNIA SNIMKGGDAG GVLGGLAGQL IGGKGRSHGG GYSGGDSYDR GSGDGGGGGG
SGLDHVISGL KKKDIGNVIG GLFGGGKGKD IGNILGGLLG KKKDKHGSGS SGGGSGYDGG
SGDYHGGGGD GGQGGGYSGG GGDQISGLIG GLIGGKKGKA ISGVIGNILG GHGGPGHRGE
GANIPADQLK GGLIETVSHF IGLGAHRFFG IDPETGRILG AIAGNLIFGL GGKDNVLGQI
GKIILDNIIS GKFKRKVEPF IPRDPTPVPR PVVPGPGPPP GLAQDFYALR DECLQNKTLF
EDSQFPASMS SLFFNRRSFE NVEWMRPGEF CQEPQLFIEG HSRFDVIQGE LGDCWLLAAA
AALTLRDELF YRVVPPDQSF TENYAGIFHF QFWRYGKWID VVIDDRLPVR NGKLLYMHSQ
SNQEFWSALL EKAYAKLHGS YEALKGGTTS EALEDFTGGL TELIDLHDPP RNVMSMVFKA
FELGSLMGCS IDADPNIWEA RMPNGLVKGH AYSITGVKML DTNYGGKVAL VRMRNPWGSA
QEWNGAWSDQ SSEWRSVPDS VKQEIELRVA HDGEFWMCFD DFLRNFEKLE ICNLGPEVMA
EIAEMTGQVS HGEKWNTNVH HGAWLQGQSA GGCKNFPKTF AMNPQYGICL TDADPDDQDD
LCTCVFGVLQ KYRRELRCKG VDVLPIGFAV FEADSNDSAL NWSQLANMKS CARSPVFINL
REVCGRFRLP PGNYVLIPST YQPNEEGEFM VRIFTTGLLE SQPLQG
//