ID A0A0V1NN23_9BILA Unreviewed; 1142 AA.
AC A0A0V1NN23;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|EMBL:KRZ85253.1};
GN Name=RAPGEF1 {ECO:0000313|EMBL:KRZ85253.1};
GN ORFNames=T08_10934 {ECO:0000313|EMBL:KRZ85253.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ85253.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ85253.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ85253.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ85253.1}.
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DR EMBL; JYDM01000147; KRZ85253.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1NN23; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924}.
FT DOMAIN 753..877
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 909..1132
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 259..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1142 AA; 129065 MW; 8EC4DD6F1296611A CRC64;
MVSSGTAGTS FMQTVKRAMR LNSTEANRPA NMANSGLRHA HSEKSLRNRI KIGGETVKQM
AAALMMQRQR SHSGSATATV QRPFQTGQKQ ANQVTLNSLE RDLKICLRFL QDAVLKRNLS
LLAGSTSAVL DVMLKLMVEP RICATDVQML YEKIYHQLGE LFQQIDRILI ANEINDNDHT
TVVGLTEHLM DTVELLHQPS RLRSGVDCAD CSAALKQEPM LRTEDRNSCD SSLTDSLDLS
TDVSSAMNQI VQEDLLLNGE AKDLVPPPRK NRQARRQETI NPPPPKPPYS SALANASAAR
QTRQPRHLHP TNPTVRLKPA SGDSGIFSFC NGSDTSLPET SDLSQSVYCN QSGAENDDAD
SFDAIIRNLQ SLNASLLPCP SACEPLVVQK ETRCDDECDG DEVVTETRVG DTIVKTTKIR
KKKVWKSTIV KHCETVLPLN SETFNASSSI LENFISNPAL DSTRNVRLTE SQIVRTEDGD
QQHFEPRAKL ASFPVDLDAL LQDEPSETHC QLIGDTVKHR SVQSFKMNTS KKAIFQKTLI
NGNVTEELSA ERYSTQLQAS SLNETYCNDQ LQNSSGKAFV TENSSLSVSG KGSSFAEVSF
RNANKSSTTT NDGCDQRKRS AVSSYMQIFG NSQPSSAADF RSSALVSYER MRDRWHVNVS
KSKQATIEFG LTTNANEDHF AHFDQANSSY ENWLDIFEND QNVDYKNLCA FLFAKKQPKQ
LQIENANRKA IADVKYLYEL DVRDHLFMKD GDDDCNIRGG LVDVLVAHAA SACHSQNGFL
YREAFLTTYR SYILPFDLLK KLVERYNHLS TQRASDEQSK SAKSCFSLIV RVVDELSHVE
ATSELLKFLV QFIHRLIVDG ELLLARLLRQ KFVEKYDEKL LAQQPNSCRP LFCRDPDQAT
KSYSIFDFKA SLLAEQITYL DWFYFQKIDA NQAEEKCPRL TEFTSHFNKM SYWVRSRILL
LADQRQREHC FVKFLKIMRH LRRLGNLNSC LALLSALDSG ALRRLDWPRS AVDQLNQYSS
LIDSSQSFKV YRTALAETKP PCLPYLGLIL QDLTFVQVGN ADYLPVEEVG VANVVNFAKR
WQQFMILDNV RRFKSWQYNI KKNDNVLVFF NNFDDYANEE QIWAISERLK PRNMSTNVPK
KL
//
