ID   A0A0V1NY30_9BILA        Unreviewed;       483 AA.
AC   A0A0V1NY30;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   03-MAY-2023, entry version 19.
DE   SubName: Full=Pancreatic triacylglycerol lipase {ECO:0000313|EMBL:KRZ88806.1};
GN   Name=PNLIP {ECO:0000313|EMBL:KRZ88806.1};
GN   ORFNames=T08_14685 {ECO:0000313|EMBL:KRZ88806.1};
OS   Trichinella sp. T8.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ88806.1, ECO:0000313|Proteomes:UP000054924};
RN   [1] {ECO:0000313|EMBL:KRZ88806.1, ECO:0000313|Proteomes:UP000054924}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS272 {ECO:0000313|EMBL:KRZ88806.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRZ88806.1}.
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DR   EMBL; JYDM01000079; KRZ88806.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1NY30; -.
DR   STRING; 92180.A0A0V1NY30; -.
DR   Proteomes; UP000054924; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; LIPASE; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..483
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5006883810"
FT   DOMAIN          40..357
FT                   /note="Lipase"
FT                   /evidence="ECO:0000259|Pfam:PF00151"
FT   ACT_SITE        184
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        203
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        289
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   BINDING         217
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         219
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         222
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
SQ   SEQUENCE   483 AA;  53331 MW;  B1861D43662B5A36 CRC64;
     MAMSAVVSSW LFPVIFTTTL AALVENYQTN KPGQELERAC YNDVGCFDNA GSFKHMKVLP
     QSPNEINTTF LLFTPESKTN GTILTKTLLL SNAKTEQVNW KNNMFVLVHG FGQFPFWMAP
     MKDALVDQNN NVIIVDWTSG SVGPNYYQAA SNTRVVGAVL ADFVSTLVKS LKISLNRLTL
     VGFSLGAHAC GFAGKNLSGL SLDPAGPLFS GKESEARLDS SDAEFVQCIH TNGQSFFRGG
     LGSVQPMGHV DFYANGGLVQ SGCADGLEEI ILDLFHLNGT ILEELTCSHS QAPVLYIETI
     KSSSFSQACQ FTSVSCDSPN SWFQGKCFNC IANGDLPAFG YKLTAQKQFK GQYYFTTLPK
     NKHHETYCGK QYGFNIIPDQ AVKGSITLTL MFSNLHSMNF TFQHIDETLE ENSHAIKIGA
     VPEFYPEITN ITIIYEKYSS WIWKNGPDEW VLKSLSLLDM ECNIHEVNPN VLVINKMATT
     VDM
//