ID A0A0V1PI63_9BILA Unreviewed; 648 AA.
AC A0A0V1PI63;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Phosphatidylinositol 4-kinase type 2 {ECO:0000256|RuleBase:RU367084};
DE EC=2.7.1.67 {ECO:0000256|RuleBase:RU367084};
GN Name=pi4k2b {ECO:0000313|EMBL:KRZ95926.1};
GN ORFNames=T08_16256 {ECO:0000313|EMBL:KRZ95926.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ95926.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ95926.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ95926.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|RuleBase:RU367084};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367084};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU367084}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00008941,
CC ECO:0000256|RuleBase:RU367084}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ95926.1}.
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DR EMBL; JYDM01000010; KRZ95926.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1PI63; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007005; P:mitochondrion organization; IEA:InterPro.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR039756; Lsb6/PI4K2.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR026120; TMEM11.
DR PANTHER; PTHR12865:SF1; PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2; 1.
DR PANTHER; PTHR12865; PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II; 1.
DR Pfam; PF14972; Mito_morph_reg; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU367084};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|RuleBase:RU367084, ECO:0000313|EMBL:KRZ95926.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367084};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU367084};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Transferase {ECO:0000256|RuleBase:RU367084}.
FT DOMAIN 143..475
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 73826 MW; 38B988E1C870DA41 CRC64;
MEKSNTSDNT SDDDKVENEE EKIVEDVAKQ CFPPLPDVTY SYSNPTPKLS NSCGGSDTAN
IRVVSDLNLR NPSLLKYKSR SRSADGIFIG DETIRSIPSL SSRREKVPLL ARMSDSSITH
CSFPGDTVYN DMFQQAEEAI EAGVYPKRIA QGSSGSYFVR NVKGEIIGVF KPKNEEPYGH
MNPKWLKWMQ RVCCPCCFGR SCLPLNQGYL SEAAASLVDE KLQLHVVPKT KVVRLAAPTF
NYSRIDHAKA QTKQRIMEKY PNIGRHFHRL GLPRKIGSLQ TFVSGYKDAN CWLAQFEQEP
LSEAAKVQFQ RQFERLVILD YIIRNTDRGS DNWLIKYVPE DQVNGEQMVD VECDDKESSA
LIKIAAIDNG LAFPLKHPDE WRAYPFHWAW LKQAREPFSD ETKRLILPRI DDLDFVMELC
DDLKKLFETD QGFDPQIFEK QMSVLRGQIL NLCQALKESK SPLQLVQMPP MIIEKTKEHM
SLPQEHSDFV VIDDAYLREN GYAVAVLEKA LMEKCSYIVI EPTVLANQAK CSISIGNFLH
RTAVLLGSAT VIIVCYFPNL PIVWGTTCGT SVVSCALYWC GWSRDPCSHY QVETDKQKLE
EMWKKNSLSF LINPVVLRYQ NDRPRRTFQM LIVVASTTFV VLKCFKLL
//
