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Database: UniProt
Entry: A0A0V2FEJ4_CAUVI
LinkDB: A0A0V2FEJ4_CAUVI
Original site: A0A0V2FEJ4_CAUVI 
ID   A0A0V2FEJ4_CAUVI        Unreviewed;       495 AA.
AC   A0A0V2FEJ4;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   05-JUL-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AS593_11615 {ECO:0000313|EMBL:KSB90852.1};
OS   Caulobacter vibrioides (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=155892 {ECO:0000313|EMBL:KSB90852.1, ECO:0000313|Proteomes:UP000053705};
RN   [1] {ECO:0000313|EMBL:KSB90852.1, ECO:0000313|Proteomes:UP000053705}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T5M6 {ECO:0000313|EMBL:KSB90852.1,
RC   ECO:0000313|Proteomes:UP000053705};
RA   Wang Y., Zheng S., Rensing C., Kot W., Wang G.;
RT   "Genome sequence of Se Oxidizing Caulobacter vibrioides T5M6.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KSB90852.1}.
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DR   EMBL; LNIY01000056; KSB90852.1; -; Genomic_DNA.
DR   RefSeq; WP_058347096.1; NZ_LNIY01000056.1.
DR   EnsemblBacteria; KSB90852; KSB90852; AS593_11615.
DR   Proteomes; UP000053705; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053705};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053705}.
FT   DOMAIN      186    314       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      403    472       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     194    201       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   495 AA;  54387 MW;  16B0CEAD273DEFC7 CRC64;
     MSIKVGAASQ ELSAAYAAVT REPAGIVWNK VCVSLKRELG DAAFGSWIAP AVLRETQAGD
     VVLVTPTGIA RDWIRRSAWR RIGELWAAGD AVGRRLDLKS RLEFEASADA ASATAGAVYV
     EAKPQPIEIV LPVSSDVPAA AAPIAGKTSP VQGLQERFTF DSFVPGPANE FAHAVARRVA
     SWADGHFNPV LFHGPYGFGK THLLNALAWE AMRAAPNKRV VYLTAERFLS TFVRAVMDRQ
     TTAFKDELRG ADLLIIDDVH FIAGKQSSQE ELFHTLTALV EDGRRVVFSA DRPPSAMTEM
     DARLRSHLSA GLVCGMEPAD RSLRLGILER KIEALGRAQG FTGSVRPEVL QFLADRFTDS
     VRELEGALNT LTARAGERLS RLSLDEVQAI LRPHLRGGEK RITIDDIQKA TSEHYGMKQA
     DLLSERRNRA IARPRQAAMW LAKQLTTRSL PDIGRRFGGR DHTTVLHAVR RIEALRQEDA
     VLSQDLETIT RKLRG
//
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